Simulation scenario 10, CR phase

Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.086, shape = 1.05	scale = 0.132, shape = 1.05	scale = 0.133, shape = 1.05	scale = 0.178, shape = 1.05	scale = 0.128, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 11.4, median = 8.2	mean = 7.4, median = 5.3	mean = 7.4, median = 5.3	mean = 5.5, median = 4	mean = 7.7, median = 5.5
all	effect	af = 1, hr = 1	af = 1.29, hr = 0.76	af = 0.84, hr = 1.19	af = 0.84, hr = 1.21	af = 0.63, hr = 1.63	af = 0.88, hr = 1.15
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.159, shape = 1.05	scale = 0.132, shape = 1.05	scale = 0.18, shape = 1.05	scale = 0.149, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 19.8, median = 14.2	mean = 6.2, median = 4.4	mean = 7.4, median = 5.3	mean = 5.5, median = 3.9	mean = 6.6, median = 4.7
AR- & TP53-	effect	af = 1, hr = 1	af = 2.25, hr = 0.43	af = 0.7, hr = 1.45	af = 0.84, hr = 1.2	af = 0.62, hr = 1.65	af = 0.75, hr = 1.35
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.086, shape = 1.05	scale = 0.135, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.153, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 11.4, median = 8.2	mean = 7.2, median = 5.2	mean = 25, median = 18	mean = 25, median = 18	mean = 6.4, median = 4.6
HRD+	effect	af = 1, hr = 1	af = 1.3, hr = 0.76	af = 0.82, hr = 1.23	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.73, hr = 1.39
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.133, shape = 1.05	scale = 0.095, shape = 1.05	scale = 0.14, shape = 1.05	scale = 0.184, shape = 1.05	scale = 0.09, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 7.4, median = 5.3	mean = 10.4, median = 7.5	mean = 7, median = 5	mean = 5.3, median = 3.8	mean = 10.9, median = 7.8
TP53+	effect	af = 1, hr = 1	af = 0.84, hr = 1.2	af = 1.18, hr = 0.84	af = 0.79, hr = 1.27	af = 0.61, hr = 1.69	af = 1.24, hr = 0.8
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.116, shape = 1.05	scale = 0.049, shape = 1.05	scale = 0.135, shape = 1.05	scale = 0.183, shape = 1.05	scale = 0.107, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.4, median = 6.1	mean = 19.9, median = 14.3	mean = 7.3, median = 5.2	mean = 5.4, median = 3.9	mean = 9.1, median = 6.6
TEfus+	effect	af = 1, hr = 1	af = 0.96, hr = 1.04	af = 2.27, hr = 0.42	af = 0.83, hr = 1.22	af = 0.61, hr = 1.68	af = 1.04, hr = 0.96
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.107, shape = 1.05	scale = 0.117, shape = 1.05	scale = 0.145, shape = 1.05	scale = 0.198, shape = 1.05	scale = 0.038, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 9.2, median = 6.6	mean = 8.4, median = 6	mean = 6.8, median = 4.9	mean = 5, median = 3.6	mean = 26.1, median = 18.8
PI3K+	effect	af = 1, hr = 1	af = 1.04, hr = 0.96	af = 0.96, hr = 1.05	af = 0.77, hr = 1.31	af = 0.56, hr = 1.83	af = 2.97, hr = 0.32

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
—–	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
—-+	param	scale = 0.112, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 19.4, median = 14	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
—-+	effect	af = 1, hr = 1	af = 2.21, hr = 0.43	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
—+-	param	scale = 0.112, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 17, median = 12.2	mean = 23.4, median = 16.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
—+-	effect	af = 1, hr = 1	af = 1.94, hr = 0.5	af = 2.67, hr = 0.36	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
—++	param	scale = 0.112, shape = 1.05	scale = 0.064, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 15.4, median = 11.1	mean = 19.4, median = 14	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
—++	effect	af = 1, hr = 1	af = 1.75, hr = 0.56	af = 2.21, hr = 0.43	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
–+-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
–++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
–++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
–+++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 19.4, median = 14	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
–+++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.21, hr = 0.43	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
-+—	param	scale = 0.112, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 17, median = 12.2	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-+—	effect	af = 1, hr = 1	af = 1.94, hr = 0.5	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 17, median = 12.2	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-+–+	effect	af = 1, hr = 1	af = 1.94, hr = 0.5	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.071, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 13.8, median = 9.9	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-+-+-	effect	af = 1, hr = 1	af = 1.56, hr = 0.62	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.071, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 13.8, median = 9.9	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-+-++	effect	af = 1, hr = 1	af = 1.56, hr = 0.62	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
-++–	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-++–	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-++-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-+++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-++++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-++++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+—+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
+–+-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
+–++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+–++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
+-+–	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+-+-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
+-++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+-+++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
++—	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
++—	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
++–+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
++–+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
++-+-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
++-++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
++-++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
+++–	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
+++–	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
+++-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
++++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.064, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 15.4, median = 11.1	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
++++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.75, hr = 0.56	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
+++++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.064, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 15.4, median = 11.1	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
+++++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.75, hr = 0.56	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 10 4 1 0 0 AR- & TP53- 186 0 3 0 1 HRD+ 3 0 184 168 0 TP53+ 0 21 0 0 19 TEfus+ 0 80 0 0 1 PI3K+ 2 2 0 0 305

TC1 TC2 TC3 TC4 TC5 all 0.020 0.008 0.002 0.000 0.000 AR- & TP53- 0.372 0.000 0.006 0.000 0.002 HRD+ 0.006 0.000 0.368 0.336 0.000 TP53+ 0.000 0.042 0.000 0.000 0.038 TEfus+ 0.000 0.160 0.000 0.000 0.002 PI3K+ 0.004 0.004 0.000 0.000 0.610

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 8 1 AR- & TP53- 0 101 31 38 22 HRD+ 12 47 0 0 78 TP53+ 105 1 79 165 0 TEfus+ 23 0 36 67 0 PI3K+ 9 3 87 154 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.016 0.002 AR- & TP53- 0.000 0.202 0.062 0.076 0.044 HRD+ 0.024 0.094 0.000 0.000 0.156 TP53+ 0.210 0.002 0.158 0.330 0.000 TEfus+ 0.046 0.000 0.072 0.134 0.000 PI3K+ 0.018 0.006 0.174 0.308 0.000

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 1 3 17 16 9 HRD+ 0 0 0 0 0 TP53+ 0 0 0 1 0 TEfus+ 0 0 0 0 0 PI3K+ 0 1 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.000 0.000 AR- & TP53- 0.002 0.006 0.034 0.032 0.018 HRD+ 0.000 0.000 0.000 0.000 0.000 TP53+ 0.000 0.000 0.000 0.002 0.000 TEfus+ 0.000 0.000 0.000 0.000 0.000 PI3K+ 0.000 0.002 0.000 0.000 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.084	0.024	0.044	0.008	0.000	0.008
err_type	0.126	0.030	0.052	0.008	0.000	0.040
pow_sign	0.916	0.372	0.160	0.368	0.336	0.610
pow_type	0.924	0.396	0.204	0.376	0.336	0.618

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	10	4	1	0	0
all	futility	0	0	0	0	8	1
all	max_n	0	0	0	0	0	0
all	n	381 (359, 402)	158 (97, 200)	172 (113, 206)	173 (129, 211)	158 (117, 196)	160 (128, 198)
all	n_unique	350 (330, 368)	142 (85, 179)	154 (100, 187)	156 (116, 191)	144 (106, 180)	145 (114, 179)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	6 (5, 8)	6 (4, 7)	6 (6, 6)	6 (6, 7)	4 (4, 4)
all	post_p	NA (NA, NA)	0.94 (0.49, 1)	0.15 (0.01, 0.59)	0.02 (0, 0.26)	0 (0, 0.01)	0.22 (0.02, 0.75)
all	rate	0.092 (0.085, 0.101)	0.076 (0.065, 0.093)	0.105 (0.091, 0.119)	0.116 (0.103, 0.13)	0.14 (0.122, 0.158)	0.102 (0.087, 0.117)
AR- & TP53-	graduation	0	186	0	3	0	1
AR- & TP53-	futility	0	0	101	31	38	22
AR- & TP53-	max_n	0	1	3	17	16	9
AR- & TP53-	n	214 (195, 234)	88 (26, 115)	96 (30, 120)	98 (77, 126)	94 (69, 117)	94 (74, 117)
AR- & TP53-	n_unique	198 (180, 215)	80 (24, 105)	88 (28, 111)	90 (70, 113)	86 (61, 109)	85 (67, 108)
AR- & TP53-	time_trial	36 (36, 36)	36 (10, 36)	36 (13, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
AR- & TP53-	time_stop	NA (NA, NA)	12 (9, 24)	13 (8, 22)	12 (9, 17)	11 (8, 16)	12 (8, 18)
AR- & TP53-	post_p	NA (NA, NA)	1 (0.98, 1)	0 (0, 0.04)	0.05 (0, 0.31)	0 (0, 0.06)	0.01 (0, 0.16)
AR- & TP53-	rate	0.084 (0.075, 0.095)	0.048 (0.038, 0.057)	0.139 (0.117, 0.17)	0.112 (0.095, 0.133)	0.138 (0.114, 0.168)	0.124 (0.102, 0.151)
HRD+	graduation	0	3	0	184	168	0
HRD+	futility	0	12	47	0	0	78
HRD+	max_n	0	0	0	0	0	0
HRD+	n	64 (55, 76)	26 (13, 40)	28 (16, 40)	27 (21, 38)	26 (18, 37)	29 (22, 40)
HRD+	n_unique	59 (50, 69)	23 (11, 35)	25 (14, 36)	24 (19, 34)	24 (16, 33)	26 (19, 36)
HRD+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (25, 36)	36 (27, 36)	36 (32, 36)
HRD+	time_stop	NA (NA, NA)	29 (24, 35)	30 (24, 35)	29 (21, 35)	30 (23, 35)	30 (24, 34)
HRD+	post_p	NA (NA, NA)	0.65 (0.25, 0.91)	0.21 (0.02, 0.65)	1 (0.94, 1)	1 (0.93, 1)	0.06 (0, 0.42)
HRD+	rate	0.097 (0.08, 0.116)	0.081 (0.059, 0.113)	0.113 (0.083, 0.161)	0.038 (0.027, 0.053)	0.038 (0.027, 0.054)	0.137 (0.097, 0.182)
TP53+	graduation	0	0	21	0	0	19
TP53+	futility	0	105	1	79	165	0
TP53+	max_n	0	0	0	0	1	0
TP53+	n	133 (118, 148)	62 (31, 80)	63 (46, 81)	61 (36, 80)	52 (26, 74)	52 (37, 71)
TP53+	n_unique	122 (108, 135)	55 (28, 70)	55 (41, 71)	54 (32, 70)	46 (24, 66)	46 (32, 63)
TP53+	time_trial	36 (36, 36)	36 (21, 36)	36 (36, 36)	36 (25, 36)	36 (16, 36)	36 (36, 36)
TP53+	time_stop	NA (NA, NA)	21 (13, 32)	19 (15, 24)	20 (15, 31)	20 (13, 30)	15 (14, 25)
TP53+	post_p	NA (NA, NA)	0.09 (0.01, 0.43)	0.95 (0.65, 1)	0.09 (0.01, 0.44)	0.01 (0, 0.15)	0.97 (0.71, 1)
TP53+	rate	0.104 (0.089, 0.119)	0.135 (0.114, 0.164)	0.077 (0.061, 0.096)	0.134 (0.11, 0.168)	0.165 (0.133, 0.208)	0.072 (0.057, 0.093)
TEfus+	graduation	0	0	80	0	0	1
TEfus+	futility	0	23	0	36	67	0
TEfus+	max_n	0	0	0	0	0	0
TEfus+	n	127 (112, 141)	56 (34, 75)	58 (30, 75)	59 (39, 77)	50 (29, 72)	52 (38, 71)
TEfus+	n_unique	116 (103, 129)	49 (31, 66)	50 (27, 67)	52 (33, 69)	44 (26, 64)	47 (34, 63)
TEfus+	time_trial	36 (36, 36)	36 (36, 36)	36 (20, 36)	36 (36, 36)	36 (25, 36)	36 (36, 36)
TEfus+	time_stop	NA (NA, NA)	24 (16, 34)	19 (14, 28)	22 (16, 30)	22 (16, 29)	15 (15, 15)
TEfus+	post_p	NA (NA, NA)	0.07 (0, 0.34)	1 (0.92, 1)	0.05 (0, 0.28)	0.01 (0, 0.13)	0.54 (0.13, 0.91)
TEfus+	rate	0.08 (0.071, 0.093)	0.112 (0.094, 0.138)	0.048 (0.038, 0.061)	0.115 (0.094, 0.148)	0.139 (0.108, 0.184)	0.082 (0.064, 0.103)
PI3K+	graduation	0	2	2	0	0	305
PI3K+	futility	0	9	3	87	154	0
PI3K+	max_n	0	0	1	0	0	0
PI3K+	n	130 (115, 144)	58 (35, 80)	62 (42, 83)	62 (30, 86)	51 (25, 76)	40 (25, 71)
PI3K+	n_unique	119 (106, 133)	50 (29, 71)	55 (37, 74)	56 (27, 77)	46 (23, 68)	36 (22, 64)
PI3K+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (21, 36)	36 (17, 36)	25 (15, 36)
PI3K+	time_stop	NA (NA, NA)	18 (13, 34)	15 (13, 25)	20 (14, 30)	19 (13, 27)	19 (14, 28)
PI3K+	post_p	NA (NA, NA)	0.48 (0.09, 0.89)	0.61 (0.16, 0.94)	0.05 (0, 0.33)	0 (0, 0.06)	1 (1, 1)
PI3K+	rate	0.098 (0.085, 0.113)	0.099 (0.079, 0.127)	0.093 (0.074, 0.118)	0.134 (0.109, 0.164)	0.174 (0.138, 0.225)	0.036 (0.027, 0.047)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	196	4	4	0	1
—–	futility	0	0	101	31	45	23
—–	max_n	0	1	3	17	16	9
—–	n	118 (105, 132)	44 (14, 59)	49 (18, 64)	53 (39, 68)	52 (36, 66)	53 (41, 68)
—–	n_unique	109 (96, 123)	41 (14, 56)	46 (17, 61)	50 (37, 64)	49 (32, 63)	50 (38, 64)
—–	post_p	NA (NA, NA)	1 (0.98, 1)	0 (0, 0.04)	0 (0, 0.08)	0 (0, 0)	0 (0, 0.01)
—–	rate	0.086 (0.072, 0.101)	0.04 (0.03, 0.053)	0.185 (0.152, 0.226)	0.158 (0.13, 0.195)	0.221 (0.182, 0.263)	0.184 (0.154, 0.223)
—-+	graduation	0	194	6	4	0	302
—-+	futility	0	9	101	109	185	20
—-+	max_n	0	1	3	17	16	7
—-+	n	30 (23, 38)	12 (3, 22)	14 (5, 22)	14 (6, 23)	12 (5, 21)	9 (4, 18)
—-+	n_unique	28 (21, 35)	11 (2, 19)	13 (4, 21)	13 (5, 21)	11 (4, 19)	8 (4, 16)
—-+	post_p	NA (NA, NA)	0.93 (0.6, 1)	0.09 (0.01, 0.33)	0.15 (0.03, 0.42)	0.05 (0, 0.23)	0.98 (0.79, 1)
—-+	rate	0.093 (0.068, 0.125)	0.049 (0.028, 0.084)	0.188 (0.13, 0.284)	0.158 (0.112, 0.239)	0.228 (0.161, 0.347)	0.036 (0.018, 0.063)
—+-	graduation	0	189	82	2	0	2
—+-	futility	0	23	95	55	96	23
—+-	max_n	0	1	3	17	16	9
—+-	n	6 (3, 9)	2 (0, 4)	2 (0, 4)	2 (0, 6)	3 (0, 5)	3 (1, 6)
—+-	n_unique	5 (3, 9)	2 (0, 4)	2 (0, 4)	2 (0, 5)	2 (0, 5)	3 (1, 5)
—+-	post_p	NA (NA, NA)	0.59 (0.4, 0.82)	0.64 (0.41, 0.86)	0.38 (0.19, 0.56)	0.32 (0.16, 0.48)	0.36 (0.18, 0.52)
—+-	rate	0.062 (0.025, 0.135)	0.055 (0, 0.189)	0.044 (0, 0.162)	0.176 (0.078, 0.542)	0.25 (0.115, 0.756)	0.201 (0.089, 0.521)
—++	graduation	0	187	84	2	0	302
—++	futility	0	31	95	123	202	20
—++	max_n	0	1	3	17	16	7
—++	n	14 (9, 19)	5 (1, 11)	6 (2, 12)	7 (3, 13)	6 (2, 11)	4 (2, 9)
—++	n_unique	13 (8, 18)	5 (1, 10)	5 (1, 11)	6 (2, 12)	5 (2, 10)	4 (1, 8)
—++	post_p	NA (NA, NA)	0.56 (0.28, 0.86)	0.71 (0.36, 0.9)	0.17 (0.03, 0.4)	0.12 (0.02, 0.32)	0.78 (0.48, 0.95)
—++	rate	0.066 (0.041, 0.108)	0.068 (0.033, 0.133)	0.051 (0.023, 0.116)	0.164 (0.096, 0.309)	0.232 (0.138, 0.458)	0.036 (0.011, 0.085)
–+–	graduation	0	10	25	1	0	19
–+–	futility	0	105	1	79	173	1
–+–	max_n	0	0	0	0	1	0
–+–	n	28 (21, 35)	12 (6, 17)	12 (7, 18)	12 (7, 17)	10 (5, 17)	12 (8, 17)
–+–	n_unique	25 (19, 32)	10 (5, 15)	11 (6, 16)	11 (6, 16)	9 (4, 15)	11 (7, 16)
–+–	post_p	NA (NA, NA)	0.48 (0.14, 0.85)	0.51 (0.18, 0.84)	0.52 (0.15, 0.86)	0.47 (0.18, 0.83)	0.51 (0.18, 0.83)
–+–	rate	0.113 (0.086, 0.148)	0.115 (0.072, 0.191)	0.113 (0.076, 0.165)	0.112 (0.075, 0.188)	0.117 (0.076, 0.198)	0.112 (0.076, 0.172)
–+-+	graduation	0	11	26	1	0	309
–+-+	futility	0	111	4	121	230	1
–+-+	max_n	0	0	1	0	1	0
–+-+	n	26 (20, 33)	12 (6, 18)	13 (8, 21)	12 (5, 19)	9 (4, 16)	8 (3, 14)
–+-+	n_unique	24 (18, 31)	10 (5, 16)	12 (6, 19)	10 (5, 17)	9 (3, 15)	7 (3, 13)
–+-+	post_p	NA (NA, NA)	0.46 (0.16, 0.83)	0.25 (0.05, 0.61)	0.34 (0.11, 0.74)	0.18 (0.04, 0.43)	0.99 (0.88, 1)
–+-+	rate	0.144 (0.11, 0.185)	0.147 (0.092, 0.228)	0.185 (0.125, 0.285)	0.166 (0.109, 0.258)	0.225 (0.159, 0.357)	0.038 (0.018, 0.068)
–++-	graduation	0	10	101	1	0	19
–++-	futility	0	120	1	106	205	1
–++-	max_n	0	0	0	0	1	0
–++-	n	8 (4, 12)	4 (1, 6)	3 (1, 6)	4 (1, 6)	3 (1, 6)	4 (1, 7)
–++-	n_unique	7 (4, 11)	3 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	post_p	NA (NA, NA)	0.42 (0.21, 0.66)	0.76 (0.48, 0.94)	0.36 (0.16, 0.58)	0.32 (0.14, 0.5)	0.32 (0.16, 0.55)
–++-	rate	0.083 (0.042, 0.153)	0.15 (0.065, 0.372)	0.037 (0, 0.118)	0.173 (0.074, 0.445)	0.244 (0.117, 0.682)	0.198 (0.094, 0.446)
–+++	graduation	0	11	102	1	0	309
–+++	futility	0	126	4	140	247	1
–+++	max_n	0	0	1	0	1	0
–+++	n	20 (14, 27)	9 (4, 15)	9 (5, 15)	9 (4, 15)	7 (3, 13)	7 (3, 13)
–+++	n_unique	18 (13, 25)	8 (4, 13)	8 (4, 13)	8 (4, 14)	6 (2, 12)	6 (2, 12)
–+++	post_p	NA (NA, NA)	0.22 (0.05, 0.54)	0.87 (0.55, 0.98)	0.18 (0.04, 0.44)	0.12 (0.02, 0.32)	0.92 (0.66, 0.99)
–+++	rate	0.089 (0.061, 0.13)	0.15 (0.093, 0.259)	0.05 (0.024, 0.089)	0.16 (0.103, 0.26)	0.232 (0.138, 0.446)	0.036 (0.015, 0.073)
-+—	graduation	0	198	4	179	163	1
-+—	futility	0	12	141	31	45	101
-+—	max_n	0	1	2	16	15	9
-+—	n	26 (20, 33)	10 (3, 17)	12 (4, 18)	11 (6, 17)	11 (6, 17)	13 (7, 19)
-+—	n_unique	24 (18, 31)	8 (2, 15)	10 (4, 16)	10 (5, 15)	10 (5, 16)	11 (6, 18)
-+—	post_p	NA (NA, NA)	0.8 (0.46, 0.97)	0.08 (0.01, 0.31)	0.95 (0.71, 1)	0.95 (0.72, 1)	0.07 (0, 0.26)
-+—	rate	0.098 (0.07, 0.134)	0.056 (0.032, 0.098)	0.186 (0.133, 0.301)	0.038 (0.02, 0.069)	0.04 (0.021, 0.067)	0.188 (0.132, 0.275)
-+–+	graduation	0	196	5	177	160	253
-+–+	futility	0	21	140	95	153	96
-+–+	max_n	0	1	3	16	15	7
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	0.52 (0.45, 0.55)	0.51 (0.5, 0.52)	0.49 (0.49, 0.49)	0.52 (0.49, 0.55)	0.49 (0.49, 0.49)
-+–+	rate	0.167 (0, 0.864)	0.04 (0, 0.45)	0.285 (0.047, 2.196)	0 (0, 0.258)	0.044 (0, 0.678)	0.043 (0, 1.341)
-+-+-	graduation	0	191	78	175	163	2
-+-+-	futility	0	35	135	54	94	101
-+-+-	max_n	0	1	2	16	15	9
-+-+-	n	13 (8, 18)	5 (1, 9)	5 (1, 9)	6 (2, 10)	6 (2, 10)	7 (3, 11)
-+-+-	n_unique	12 (8, 17)	4 (1, 9)	4 (1, 8)	5 (2, 9)	5 (2, 9)	6 (3, 10)
-+-+-	post_p	NA (NA, NA)	0.5 (0.2, 0.76)	0.57 (0.3, 0.84)	0.76 (0.46, 0.93)	0.74 (0.42, 0.95)	0.12 (0.02, 0.3)
-+-+-	rate	0.073 (0.044, 0.116)	0.073 (0.036, 0.153)	0.059 (0.024, 0.149)	0.038 (0.015, 0.082)	0.039 (0.016, 0.092)	0.202 (0.116, 0.37)
-+-++	graduation	0	189	79	173	160	253
-+-++	futility	0	43	134	109	168	96
-+-++	max_n	0	1	3	16	15	7
-+-++	n	5 (3, 9)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)
-+-++	n_unique	5 (2, 8)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 4)	2 (0, 4)
-+-++	post_p	NA (NA, NA)	0.45 (0.28, 0.63)	0.49 (0.32, 0.68)	0.57 (0.39, 0.78)	0.56 (0.39, 0.76)	0.56 (0.38, 0.75)
-+-++	rate	0.073 (0.036, 0.163)	0.078 (0.024, 0.238)	0.063 (0, 0.192)	0.037 (0, 0.119)	0.043 (0, 0.139)	0.041 (0, 0.134)
-++–	graduation	0	13	23	176	166	16
-++–	futility	0	113	48	69	129	79
-++–	max_n	0	0	0	0	1	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.46 (0.4, 0.52)	0.49 (0.42, 0.62)	0.44 (0.41, 0.47)	0.45 (0.44, 0.47)	0.5 (0.44, 0.54)
-++–	rate	0.129 (0, 1.059)	0.115 (0.008, 0.672)	0.232 (0, 1.526)	0.051 (0, 0.19)	0.048 (0, 0.513)	0.244 (0, 1.347)
-++-+	graduation	0	14	23	175	163	260
-++-+	futility	0	119	49	104	173	77
-++-+	max_n	0	0	1	0	1	0
-++-+	n	3 (1, 6)	1 (0, 4)	2 (0, 4)	1 (0, 4)	1 (0, 3)	1 (0, 3)
-++-+	n_unique	3 (1, 6)	1 (0, 3)	1 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)
-++-+	post_p	NA (NA, NA)	0.44 (0.33, 0.6)	0.42 (0.28, 0.55)	0.62 (0.43, 0.81)	0.6 (0.43, 0.79)	0.58 (0.43, 0.75)
-++-+	rate	0.157 (0.07, 0.384)	0.158 (0.048, 0.571)	0.196 (0.062, 0.769)	0.035 (0, 0.175)	0.041 (0, 0.216)	0.044 (0, 0.199)
-+++-	graduation	0	13	95	174	166	16
-+++-	futility	0	128	48	96	160	79
-+++-	max_n	0	0	0	0	1	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.44 (0.43, 0.45)	0.49 (0.47, 0.51)	0.57 (0.57, 0.57)	0.54 (0.49, 0.57)	0.53 (0.5, 0.55)
-+++-	rate	0.175 (0, 1.025)	0.158 (0, 0.473)	0.072 (0, 0.545)	0 (0, 0.222)	0.121 (0, 0.693)	0.121 (0, 0.381)
-++++	graduation	0	14	95	173	163	260
-++++	futility	0	134	49	123	189	77
-++++	max_n	0	0	1	0	1	0
-++++	n	3 (1, 6)	2 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)	1 (0, 3)
-++++	n_unique	3 (1, 6)	2 (0, 4)	1 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)
-++++	post_p	NA (NA, NA)	0.41 (0.25, 0.53)	0.52 (0.38, 0.71)	0.56 (0.41, 0.74)	0.56 (0.42, 0.75)	0.56 (0.4, 0.71)
-++++	rate	0.106 (0.036, 0.275)	0.165 (0.054, 0.56)	0.062 (0, 0.263)	0.042 (0, 0.176)	0.038 (0, 0.191)	0.046 (0, 0.178)
+—-	graduation	0	10	4	1	0	0
+—-	futility	0	0	0	0	8	1
+—-	max_n	0	0	0	0	0	0
+—-	n	6 (3, 10)	2 (1, 5)	2 (1, 5)	2 (1, 5)	3 (1, 5)	3 (1, 5)
+—-	n_unique	5 (3, 9)	2 (0, 4)	2 (1, 4)	2 (0, 4)	2 (0, 4)	2 (1, 4)
+—-	post_p	NA (NA, NA)	0.47 (0.25, 0.74)	0.49 (0.29, 0.73)	0.49 (0.27, 0.74)	0.5 (0.31, 0.74)	0.51 (0.29, 0.73)
+—-	rate	0.119 (0.061, 0.232)	0.127 (0.036, 0.433)	0.12 (0.042, 0.391)	0.12 (0.04, 0.359)	0.118 (0.032, 0.341)	0.114 (0.038, 0.32)
+—+	graduation	0	12	6	1	0	305
+—+	futility	0	9	3	87	162	1
+—+	max_n	0	0	1	0	0	0
+—+	n	2 (1, 5)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 2)	1 (0, 2)
+—+	n_unique	2 (1, 5)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 2)	1 (0, 2)
+—+	post_p	NA (NA, NA)	0.48 (0.37, 0.67)	0.46 (0.33, 0.62)	0.48 (0.34, 0.65)	0.45 (0.32, 0.61)	0.61 (0.44, 0.79)
+—+	rate	0.155 (0.064, 0.505)	0.152 (0, 0.638)	0.222 (0.062, 0.776)	0.166 (0.031, 0.912)	0.25 (0.066, 1.041)	0.054 (0, 0.243)
+–+-	graduation	0	10	84	1	0	1
+–+-	futility	0	23	0	36	75	1
+–+-	max_n	0	0	0	0	0	0
+–+-	n	9 (5, 13)	4 (1, 7)	3 (1, 6)	4 (2, 7)	4 (1, 7)	4 (2, 7)
+–+-	n_unique	8 (5, 12)	3 (1, 6)	3 (1, 6)	4 (1, 6)	3 (1, 6)	3 (1, 6)
+–+-	post_p	NA (NA, NA)	0.41 (0.18, 0.64)	0.79 (0.52, 0.96)	0.37 (0.15, 0.62)	0.3 (0.12, 0.49)	0.32 (0.13, 0.55)
+–+-	rate	0.085 (0.046, 0.147)	0.154 (0.07, 0.383)	0.041 (0, 0.097)	0.167 (0.084, 0.424)	0.231 (0.114, 0.563)	0.207 (0.101, 0.448)
+–++	graduation	0	12	86	1	0	305
+–++	futility	0	31	3	107	186	1
+–++	max_n	0	0	1	0	0	0
+–++	n	4 (2, 8)	2 (0, 5)	2 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)
+–++	n_unique	4 (2, 7)	2 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 4)	1 (0, 3)
+–++	post_p	NA (NA, NA)	0.44 (0.27, 0.6)	0.58 (0.39, 0.8)	0.42 (0.27, 0.6)	0.38 (0.21, 0.53)	0.64 (0.45, 0.84)
+–++	rate	0.102 (0.047, 0.247)	0.148 (0.06, 0.439)	0.065 (0, 0.245)	0.177 (0.065, 0.645)	0.253 (0.09, 0.849)	0.041 (0, 0.143)
+-+–	graduation	0	10	25	1	0	19
+-+–	futility	0	105	1	79	173	1
+-+–	max_n	0	0	0	0	1	0
+-+–	n	2 (0, 4)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	2 (0, 4)	0 (0, 2)	1 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.5 (0.39, 0.65)	0.48 (0.35, 0.63)	0.51 (0.36, 0.66)	0.46 (0.37, 0.59)	0.48 (0.35, 0.62)
+-+–	rate	0.177 (0.048, 0.555)	0.167 (0, 0.803)	0.22 (0.053, 1.045)	0.178 (0, 1.017)	0.262 (0.088, 1.184)	0.215 (0, 1.008)
+-+-+	graduation	0	11	26	1	0	309
+-+-+	futility	0	111	4	121	230	1
+-+-+	max_n	0	0	1	0	1	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	0.5 (0.5, 0.52)	0.53 (0.53, 0.53)	0.45 (0.45, 0.45)	0.48 (0.48, 0.48)	NA (NA, NA)
+-+-+	rate	0.142 (0, 1.576)	0.126 (0, 0.753)	0.348 (0.124, 1.292)	0.178 (0, 1.135)	0.307 (0.119, 1.426)	0.055 (0, 0.138)
+-++-	graduation	0	10	101	1	0	19
+-++-	futility	0	120	1	106	205	1
+-++-	max_n	0	0	0	0	1	0
+-++-	n	22 (17, 29)	10 (5, 14)	9 (5, 15)	9 (5, 14)	8 (3, 14)	11 (6, 16)
+-++-	n_unique	21 (15, 27)	8 (4, 13)	8 (4, 14)	8 (4, 13)	7 (3, 13)	10 (5, 14)
+-++-	post_p	NA (NA, NA)	0.27 (0.08, 0.62)	0.96 (0.75, 1)	0.2 (0.04, 0.47)	0.11 (0.02, 0.31)	0.11 (0.02, 0.42)
+-++-	rate	0.082 (0.059, 0.118)	0.14 (0.093, 0.235)	0.038 (0.018, 0.071)	0.172 (0.11, 0.277)	0.232 (0.15, 0.418)	0.19 (0.122, 0.284)
+-+++	graduation	0	11	102	1	0	309
+-+++	futility	0	126	4	140	247	1
+-+++	max_n	0	0	1	0	1	0
+-+++	n	17 (12, 23)	8 (3, 14)	8 (4, 14)	8 (3, 13)	6 (2, 12)	5 (2, 11)
+-+++	n_unique	16 (11, 21)	7 (3, 12)	7 (3, 12)	7 (3, 12)	5 (2, 10)	5 (2, 10)
+-+++	post_p	NA (NA, NA)	0.29 (0.09, 0.61)	0.82 (0.46, 0.97)	0.24 (0.06, 0.49)	0.16 (0.03, 0.38)	0.9 (0.65, 0.99)
+-+++	rate	0.099 (0.067, 0.141)	0.147 (0.09, 0.252)	0.059 (0.031, 0.108)	0.164 (0.107, 0.301)	0.238 (0.139, 0.405)	0.037 (0.013, 0.078)
++—	graduation	0	13	4	185	168	0
++—	futility	0	12	47	0	8	79
++—	max_n	0	0	0	0	0	0
++—	n	9 (6, 14)	4 (2, 7)	4 (2, 7)	4 (2, 7)	4 (1, 7)	4 (2, 7)
++—	n_unique	9 (5, 13)	3 (1, 6)	4 (1, 7)	3 (1, 6)	3 (1, 6)	4 (1, 6)
++—	post_p	NA (NA, NA)	0.44 (0.22, 0.68)	0.33 (0.14, 0.57)	0.84 (0.55, 0.97)	0.83 (0.58, 0.96)	0.33 (0.15, 0.57)
++—	rate	0.149 (0.095, 0.251)	0.146 (0.072, 0.326)	0.21 (0.102, 0.48)	0.038 (0, 0.105)	0.041 (0, 0.097)	0.197 (0.096, 0.475)
++–+	graduation	0	15	5	183	165	256
++–+	futility	0	21	48	72	130	77
++–+	max_n	0	0	1	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	0.48 (0.45, 0.52)	0.52 (0.49, 0.55)	0.57 (0.57, 0.57)	0.51 (0.48, 0.54)	0.56 (0.56, 0.56)
++–+	rate	0.201 (0.037, 0.738)	0.312 (0.022, 1.218)	0.305 (0.013, 3.712)	0.066 (0, 0.537)	0.047 (0, 0.293)	0 (0, 0.256)
++-+-	graduation	0	13	80	183	168	1
++-+-	futility	0	35	47	35	73	79
++-+-	max_n	0	0	0	0	0	0
++-+-	n	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	n_unique	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 1)
++-+-	post_p	NA (NA, NA)	0.47 (0.39, 0.58)	0.54 (0.43, 0.65)	0.55 (0.42, 0.64)	0.54 (0.44, 0.63)	0.44 (0.36, 0.54)
++-+-	rate	0.121 (0, 0.444)	0.149 (0, 0.625)	0.05 (0, 0.305)	0.021 (0, 0.214)	0.026 (0, 0.23)	0.243 (0, 1.178)
++-++	graduation	0	15	81	181	165	256
++-++	futility	0	43	48	92	152	77
++-++	max_n	0	0	1	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	0.48 (0.48, 0.48)	0.48 (0.48, 0.48)	0.57 (0.54, 0.61)	0.55 (0.55, 0.55)	0.51 (0.44, 0.59)
++-++	rate	0.248 (0, 1.234)	0.283 (0.101, 1.32)	0.083 (0, 0.248)	0.036 (0, 0.234)	0.016 (0, 0.126)	0.093 (0, 0.22)
+++–	graduation	0	13	23	176	166	16
+++–	futility	0	113	48	69	129	79
+++–	max_n	0	0	0	0	1	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.53 (0.45, 0.58)	0.46 (0.41, 0.57)	0.55 (0.48, 0.6)	0.54 (0.51, 0.62)	0.48 (0.43, 0.57)
+++–	rate	0.207 (0.047, 1.078)	0.147 (0, 0.734)	0.255 (0, 1.371)	0 (0, 0.2)	0.042 (0, 0.422)	0.242 (0, 1.094)
+++-+	graduation	0	14	23	175	163	260
+++-+	futility	0	119	49	104	173	77
+++-+	max_n	0	0	1	0	1	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.55 (0.54, 0.56)	0.5 (0.47, 0.55)	0.54 (0.46, 0.58)	0.54 (0.54, 0.54)	0.52 (0.51, 0.54)
+++-+	rate	0.163 (0, 0.943)	0.071 (0, 0.877)	0.288 (0, 1.242)	0 (0, 0.154)	0 (0, 0.081)	0.057 (0, 0.344)
++++-	graduation	0	13	95	174	166	16
++++-	futility	0	128	48	96	160	79
++++-	max_n	0	0	0	0	1	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	0.46 (0.42, 0.5)	0.52 (0.48, 0.55)	0.52 (0.5, 0.54)	NA (NA, NA)	NA (NA, NA)
++++-	rate	0.088 (0, 0.293)	0.115 (0, 0.607)	0.099 (0, 0.621)	0.076 (0, 0.653)	0 (0, 0.146)	0.192 (0.026, 0.352)
+++++	graduation	0	14	95	173	163	260
+++++	futility	0	134	49	123	189	77
+++++	max_n	0	0	1	0	1	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	0.46 (0.42, 0.49)	0.58 (0.51, 0.6)	0.48 (0.48, 0.48)	0.49 (0.48, 0.5)	0.68 (0.68, 0.68)
+++++	rate	0.132 (0, 0.923)	0.063 (0, 0.453)	0 (0, 0.295)	0 (0, 0.167)	0.064 (0, 0.658)	0.022 (0, 0.148)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	10	4	1
all	time_stop	6 (5, 8)	6 (4, 7)	6 (6, 6)
all	n_trt	30 (25, 32)	29 (26, 34)	25 (25, 25)
all	n_control	50 (35, 74)	48 (34, 56)	49 (49, 49)
all	post_p	0.93 (0.88, 1)	0.95 (0.93, 0.96)	0.89 (0.89, 0.89)
all	order	1 (1, 1)	1 (1, 1)	1 (1, 1)
AR- & TP53-	count	186		3		1
AR- & TP53-	time_stop	12 (9, 24)		7 (6, 12)		11 (11, 11)
AR- & TP53-	n_trt	30 (25, 64)		28 (26, 28)		25 (25, 25)
AR- & TP53-	n_control	69 (44, 150)		43 (25, 73)		64 (64, 64)
AR- & TP53-	post_p	0.99 (0.95, 1)		0.9 (0.89, 0.94)		0.96 (0.96, 0.96)
AR- & TP53-	order	1 (1, 2)		1 (1, 1)		1 (1, 1)
HRD+	count	3		184	168
HRD+	time_stop	32 (30, 32)		29 (21, 35)	30 (23, 35)
HRD+	n_trt	29 (26, 31)		26 (25, 32)	26 (25, 31)
HRD+	n_control	56 (52, 66)		50 (36, 66)	53 (38, 68)
HRD+	post_p	0.94 (0.93, 0.94)		1 (0.98, 1)	1 (0.98, 1)
HRD+	order	2 (1.2, 2.8)		2 (1, 3)	2 (1, 4)
TP53+	count		21			19
TP53+	time_stop		20 (15, 24)			15 (14, 25)
TP53+	n_trt		29 (25, 38)			26 (25, 36)
TP53+	n_control		70 (49, 97)			53 (39, 77)
TP53+	post_p		0.98 (0.94, 1)			0.98 (0.96, 1)
TP53+	order		2 (1, 3)			1 (1, 2.2)
TEfus+	count		80			1
TEfus+	time_stop		19 (14, 28)			15 (15, 15)
TEfus+	n_trt		30 (25, 51)			30 (30, 30)
TEfus+	n_control		62 (43, 100)			41 (41, 41)
TEfus+	post_p		0.99 (0.96, 1)			0.98 (0.98, 0.98)
TEfus+	order		2 (1, 3)			2 (2, 2)
PI3K+	count	2	2			305
PI3K+	time_stop	18 (14, 22)	18 (14, 21)			19 (14, 28)
PI3K+	n_trt	30 (26, 34)	27 (26, 28)			28 (25, 52)
PI3K+	n_control	57 (45, 69)	61 (45, 77)			64 (46, 102)
PI3K+	post_p	0.98 (0.96, 0.99)	0.95 (0.92, 0.98)			1 (0.99, 1)
PI3K+	order	2.5 (2.1, 2.9)	2.5 (2.1, 2.9)			1 (1, 2)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count				8	1
all	time_stop				6 (6, 7)	4 (4, 4)
all	n_trt				34 (25, 36)	28 (28, 28)
all	n_control				52 (45, 74)	34 (34, 34)
all	post_p				0.01 (0, 0.2)	0.08 (0.08, 0.08)
all	order				1 (1, 1)	1 (1, 1)
AR- & TP53-	count		101	31	38	22
AR- & TP53-	time_stop		13 (8, 22)	12 (9, 17)	11 (8, 16)	12 (8, 18)
AR- & TP53-	n_trt		31 (25, 55)	29 (25, 42)	27 (25, 43)	30 (26, 47)
AR- & TP53-	n_control		72 (40, 134)	61 (49, 97)	58 (40, 101)	66 (36, 101)
AR- & TP53-	post_p		0.03 (0, 0.16)	0.05 (0, 0.16)	0.02 (0, 0.1)	0.05 (0.01, 0.16)
AR- & TP53-	order		1 (1, 2)	1 (1, 2)	1 (1, 2)	1 (1, 2)
HRD+	count	12	47			78
HRD+	time_stop	28 (22, 35)	30 (24, 35)			30 (24, 34)
HRD+	n_trt	27 (25, 30)	27 (25, 35)			26 (25, 33)
HRD+	n_control	48 (36, 63)	52 (42, 67)			52 (38, 63)
HRD+	post_p	0.09 (0.04, 0.19)	0.04 (0, 0.21)			0.02 (0, 0.14)
HRD+	order	2 (1, 4)	2 (1, 4)			2 (1, 4)
TP53+	count	105	1	79	165
TP53+	time_stop	21 (13, 32)	18 (18, 18)	20 (15, 31)	20 (13, 30)
TP53+	n_trt	36 (26, 54)	28 (28, 28)	34 (25, 57)	28 (25, 44)
TP53+	n_control	76 (44, 114)	63 (63, 63)	76 (48, 117)	71 (47, 111)
TP53+	post_p	0.04 (0.01, 0.14)	0.06 (0.06, 0.06)	0.04 (0, 0.13)	0.02 (0, 0.07)
TP53+	order	2 (1, 4)	1 (1, 1)	2 (1, 4)	2 (1, 4)
TEfus+	count	23		36	67
TEfus+	time_stop	24 (16, 34)		22 (16, 30)	22 (16, 29)
TEfus+	n_trt	35 (26, 58)		31 (26, 43)	31 (25, 43)
TEfus+	n_control	92 (56, 121)		82 (46, 110)	75 (50, 104)
TEfus+	post_p	0.01 (0, 0.09)		0.01 (0, 0.06)	0 (0, 0.05)
TEfus+	order	3 (1, 5)		2 (1, 4)	2 (1, 4)
PI3K+	count	9	3	87	154
PI3K+	time_stop	18 (12, 34)	15 (13, 25)	20 (14, 30)	19 (13, 27)
PI3K+	n_trt	28 (25, 50)	27 (26, 33)	29 (25, 51)	27 (25, 43)
PI3K+	n_control	71 (41, 118)	50 (42, 103)	70 (47, 104)	67 (44, 102)
PI3K+	post_p	0.08 (0.04, 0.23)	0.12 (0.09, 0.18)	0.04 (0, 0.13)	0.01 (0, 0.07)
PI3K+	order	2 (1, 3)	2 (2, 2.8)	2 (1, 4)	2 (1, 3.7)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
all	TC1	time	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)
all	TC1	n	11 (6, 13)	4 (1, 4)	1 (0, 1)	1 (0, 4)	2 (1, 3)	2 (0, 4)	0 (0, 1)	2 (0, 2)	2 (1, 4)	0 (0, 0)	0 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (0, 3)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.93 (0.64, 0.96)	0.54 (0.5, 0.61)	0.54 (0.51, 0.61)	0.53 (0.51, 0.57)	0.54 (0.51, 0.65)	0.54 (0.53, 0.62)	0.53 (0.52, 0.54)	0.58 (0.53, 0.66)	0.53 (0.52, 0.57)	NA (NA, NA)	0.5 (0.5, 0.54)	0.54 (0.53, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	0.54 (0.52, 0.6)	NA (NA, NA)	0.51 (0.5, 0.55)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)	0.59 (0.53, 0.64)	0.57 (0.53, 0.61)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.027 (0, 0.049)	0.031 (0, 0.115)	0 (0, 0.097)	0 (0, 0)	0 (0, 0.067)	0.022 (0, 0.148)	0 (0, 0)	0 (0, 0.031)	0 (0, 0.076)	NA (NA, NA)	0 (0, 0.143)	0 (0, 1.286)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0.124)	0.426 (0.426, 0.426)	0 (0, 0.085)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.15)	0 (0, 0.503)	0 (0, 0.601)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC2	time	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)
all	TC2	n	9 (5, 12)	2 (0, 4)	0 (0, 1)	0 (0, 2)	2 (2, 3)	2 (1, 4)	0 (0, 1)	0 (0, 1)	2 (1, 3)	0 (0, 0)	2 (1, 3)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 1)	0 (0, 0)	0 (0, 0)	3 (2, 5)	2 (1, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.63 (0.53, 0.68)	0.53 (0.51, 0.56)	NA (NA, NA)	0.53 (0.53, 0.53)	0.62 (0.58, 0.67)	0.56 (0.55, 0.58)	0.54 (0.53, 0.56)	0.53 (0.53, 0.53)	0.54 (0.51, 0.54)	NA (NA, NA)	0.53 (0.53, 0.53)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	0.55 (0.54, 0.55)	0.55 (0.55, 0.55)	0.55 (0.54, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.09 (0.023, 0.117)	0 (0, 0.088)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.065)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.859)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.03)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC3	time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
all	TC3	n	5 (5, 5)	6 (6, 6)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	3 (3, 3)	4 (4, 4)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.64 (0.64, 0.64)	0.6 (0.6, 0.6)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.6 (0.6, 0.6)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.058 (0.058, 0.058)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.086 (0.086, 0.086)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.128 (0.128, 0.128)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	186	186	186	186					186	186	186	186
AR- & TP53-	TC1	time	12 (9, 24)	12 (9, 24)	12 (9, 24)	12 (9, 24)					12 (9, 24)	12 (9, 24)	12 (9, 24)	12 (9, 24)
AR- & TP53-	TC1	n	17 (13, 34)	5 (2, 10)	1 (0, 2)	2 (0, 5)					4 (2, 9)	0 (0, 0)	2 (0, 5)	1 (0, 2)
AR- & TP53-	TC1	post_p	0.97 (0.86, 1)	0.72 (0.55, 0.93)	0.56 (0.51, 0.72)	0.55 (0.51, 0.72)					0.66 (0.53, 0.87)	0.52 (0.52, 0.52)	0.55 (0.51, 0.65)	0.54 (0.51, 0.61)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.037 (0.013, 0.066)	0.032 (0, 0.08)	0 (0, 0.084)	0.036 (0, 0.088)					0.029 (0, 0.081)	0.143 (0.029, 0.258)	0 (0, 0.074)	0 (0, 0.213)
AR- & TP53-	TC3	count	3	3	3	3					3	3	3	3
AR- & TP53-	TC3	time	7 (6, 12)	7 (6, 12)	7 (6, 12)	7 (6, 12)					7 (6, 12)	7 (6, 12)	7 (6, 12)	7 (6, 12)
AR- & TP53-	TC3	n	16 (14, 18)	3 (1, 5)	1 (1, 1)	1 (0, 3)					5 (3, 5)	0 (0, 0)	1 (1, 2)	0 (0, 0)
AR- & TP53-	TC3	post_p	0.79 (0.73, 0.87)	0.61 (0.57, 0.64)	0.52 (0.51, 0.53)	0.52 (0.51, 0.53)					0.67 (0.58, 0.69)	NA (NA, NA)	0.52 (0.52, 0.57)	NA (NA, NA)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.072 (0.067, 0.077)	0 (0, 0.167)	0 (0, 0)	0.048 (0.01, 0.087)					0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
AR- & TP53-	TC5	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC5	time	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)
AR- & TP53-	TC5	n	12 (12, 12)	8 (8, 8)	0 (0, 0)	1 (1, 1)					1 (1, 1)	0 (0, 0)	0 (0, 0)	3 (3, 3)
AR- & TP53-	TC5	post_p	0.83 (0.83, 0.83)	0.77 (0.77, 0.77)	NA (NA, NA)	0.54 (0.54, 0.54)					0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.122 (0.122, 0.122)	0.05 (0.05, 0.05)	NA (NA, NA)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.048 (0.048, 0.048)
HRD+	TC1	count									3	3	3	3	3	3	3	3									3	3	3	3	3	3	3	3
HRD+	TC1	time									32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)									32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)	32 (30, 32)
HRD+	TC1	n									14 (13, 14)	0 (0, 0)	6 (5, 8)	4 (2, 5)	0 (0, 0)	2 (0, 3)	0 (0, 0)	1 (0, 1)									3 (1, 4)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.84 (0.75, 0.86)	NA (NA, NA)	0.76 (0.68, 0.76)	0.59 (0.58, 0.59)	NA (NA, NA)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)									0.59 (0.54, 0.64)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.054 (0.046, 0.057)	NA (NA, NA)	0.044 (0.032, 0.054)	0.053 (0.011, 0.057)	NA (NA, NA)	0.052 (0.01, 0.093)	NA (NA, NA)	0.115 (0.023, 0.207)									0.097 (0.078, 0.116)	NA (NA, NA)	0.078 (0.078, 0.078)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									184	184	184	184	184	184	184	184									184	184	184	184	184	184	184	184
HRD+	TC3	time									29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)									29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)
HRD+	TC3	n									11 (7, 15)	0 (0, 0)	5 (3, 8)	2 (0, 5)	0 (0, 0)	2 (0, 3)	0 (0, 0)	2 (0, 4)									3 (1, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.94 (0.75, 0.99)	0.5 (0.5, 0.5)	0.75 (0.61, 0.9)	0.59 (0.52, 0.76)	NA (NA, NA)	0.62 (0.53, 0.75)	NA (NA, NA)	0.58 (0.51, 0.7)									0.78 (0.58, 0.95)	NA (NA, NA)	0.58 (0.52, 0.64)	NA (NA, NA)	0.57 (0.55, 0.59)	0.54 (0.54, 0.54)	NA (NA, NA)	0.51 (0.51, 0.51)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.035 (0.014, 0.063)	0.198 (0.062, 1.818)	0.03 (0, 0.058)	0.013 (0, 0.059)	0 (0, 0.057)	0 (0, 0.104)	0 (0, 0.272)	0.026 (0, 0.085)									0.032 (0, 0.092)	0 (0, 0.051)	0 (0, 0.106)	0 (0, 0.182)	0 (0, 0.156)	0 (0, 0.056)	0 (0, 0.436)	0 (0, 0.042)
HRD+	TC4	count									168	168	168	168	168	168	168	168									168	168	168	168	168	168	168	168
HRD+	TC4	time									30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)									30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)
HRD+	TC4	n									11 (7, 15)	0 (0, 0)	6 (3, 9)	2 (0, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									4 (2, 7)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.93 (0.77, 0.99)	0.55 (0.55, 0.55)	0.78 (0.58, 0.92)	0.57 (0.51, 0.71)	0.51 (0.51, 0.51)	0.59 (0.52, 0.77)	NA (NA, NA)	0.59 (0.52, 0.76)									0.82 (0.59, 0.96)	0.51 (0.51, 0.51)	0.57 (0.52, 0.65)	NA (NA, NA)	0.59 (0.52, 0.67)	NA (NA, NA)	NA (NA, NA)	0.52 (0.51, 0.52)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.038 (0.017, 0.059)	0.021 (0, 0.967)	0.03 (0.012, 0.058)	0.026 (0, 0.068)	0 (0, 0.264)	0 (0, 0.093)	0.09 (0, 0.821)	0 (0, 0.08)									0.037 (0, 0.082)	0.723 (0.145, 1.301)	0 (0, 0.183)	0.139 (0.113, 0.165)	0.055 (0, 1.315)	0.026 (0.005, 0.047)	0.033 (0.007, 0.059)	0.086 (0, 2.728)
TP53+	TC2	count					21	21	21	21					21	21	21	21					21	21	21	21					21	21	21	21
TP53+	TC2	time					20 (15, 24)	20 (15, 24)	20 (15, 24)	20 (15, 24)					20 (15, 24)	20 (15, 24)	20 (15, 24)	20 (15, 24)					20 (15, 24)	20 (15, 24)	20 (15, 24)	20 (15, 24)					20 (15, 24)	20 (15, 24)	20 (15, 24)	20 (15, 24)
TP53+	TC2	n					5 (3, 12)	5 (3, 9)	2 (0, 5)	4 (2, 7)					0 (0, 0)	0 (0, 1)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	5 (2, 7)	3 (2, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.72 (0.57, 0.82)	0.63 (0.53, 0.76)	0.62 (0.53, 0.76)	0.74 (0.62, 0.91)					NA (NA, NA)	0.53 (0.52, 0.54)	NA (NA, NA)	0.54 (0.51, 0.6)					0.55 (0.51, 0.59)	NA (NA, NA)	0.82 (0.59, 0.92)	0.82 (0.56, 0.93)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.072 (0.027, 0.093)	0.106 (0.065, 0.128)	0.038 (0, 0.131)	0.04 (0, 0.098)					NA (NA, NA)	0.114 (0, 1.064)	NA (NA, NA)	0 (0, 0.196)					0.1 (0, 8.222)	NA (NA, NA)	0.037 (0, 0.059)	0.027 (0, 0.068)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
TP53+	TC5	count					19	19	19	19					19	19	19	19					19	19	19	19					19	19	19	19
TP53+	TC5	time					15 (14, 25)	15 (14, 25)	15 (14, 25)	15 (14, 25)					15 (14, 25)	15 (14, 25)	15 (14, 25)	15 (14, 25)					15 (14, 25)	15 (14, 25)	15 (14, 25)	15 (14, 25)					15 (14, 25)	15 (14, 25)	15 (14, 25)	15 (14, 25)
TP53+	TC5	n					5 (3, 10)	6 (3, 10)	1 (0, 3)	4 (2, 8)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	4 (2, 6)	4 (2, 6)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.7 (0.53, 0.75)	0.89 (0.74, 0.98)	0.57 (0.53, 0.69)	0.73 (0.6, 0.95)					NA (NA, NA)	0.55 (0.52, 0.72)	NA (NA, NA)	0.58 (0.55, 0.63)					0.57 (0.53, 0.67)	NA (NA, NA)	0.55 (0.51, 0.73)	0.73 (0.59, 0.86)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.078 (0.043, 0.11)	0.031 (0, 0.067)	0.064 (0, 0.139)	0.026 (0, 0.069)					NA (NA, NA)	0 (0, 0.099)	NA (NA, NA)	0 (0, 0.1)					0.169 (0, 0.249)	NA (NA, NA)	0.086 (0.042, 0.131)	0.017 (0, 0.068)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			80	80			80	80			80	80			80	80			80	80			80	80			80	80			80	80
TEfus+	TC2	time			19 (14, 28)	19 (14, 28)			19 (14, 28)	19 (14, 28)			19 (14, 28)	19 (14, 28)			19 (14, 28)	19 (14, 28)			19 (14, 28)	19 (14, 28)			19 (14, 28)	19 (14, 28)			19 (14, 28)	19 (14, 28)			19 (14, 28)	19 (14, 28)
TEfus+	TC2	n			1 (0, 3)	3 (1, 7)			2 (0, 5)	6 (3, 10)			3 (1, 5)	2 (0, 3)			0 (0, 0)	1 (0, 3)			2 (0, 4)	1 (0, 3)			6 (3, 11)	4 (2, 9)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.61 (0.53, 0.77)	0.64 (0.53, 0.82)			0.64 (0.53, 0.86)	0.76 (0.58, 0.92)			0.59 (0.52, 0.81)	0.55 (0.51, 0.65)			NA (NA, NA)	0.55 (0.51, 0.65)			0.65 (0.54, 0.85)	0.59 (0.52, 0.69)			0.84 (0.68, 0.97)	0.72 (0.54, 0.89)			0.52 (0.5, 0.58)	NA (NA, NA)			0.51 (0.51, 0.51)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0 (0, 0.098)	0.038 (0, 0.085)			0.023 (0, 0.09)	0.031 (0, 0.082)			0.026 (0, 0.083)	0 (0, 0.117)			0 (0, 0)	0 (0, 0.108)			0.015 (0, 0.089)	0 (0, 0.125)			0.034 (0, 0.073)	0.043 (0, 0.088)			0 (0, 0.381)	0.191 (0.167, 0.216)			0.152 (0.03, 0.274)	NA (NA, NA)
TEfus+	TC5	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC5	time			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)
TEfus+	TC5	n			1 (1, 1)	1 (1, 1)			0 (0, 0)	8 (8, 8)			3 (3, 3)	2 (2, 2)			0 (0, 0)	3 (3, 3)			1 (1, 1)	0 (0, 0)			5 (5, 5)	6 (6, 6)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			NA (NA, NA)	0.61 (0.61, 0.61)			NA (NA, NA)	0.84 (0.84, 0.84)			0.59 (0.59, 0.59)	0.58 (0.58, 0.58)			NA (NA, NA)	0.58 (0.58, 0.58)			0.59 (0.59, 0.59)	NA (NA, NA)			0.55 (0.55, 0.55)	0.73 (0.73, 0.73)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			9.681 (9.681, 9.681)	0 (0, 0)			NA (NA, NA)	0.033 (0.033, 0.033)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	0 (0, 0)			0 (0, 0)	NA (NA, NA)			0.113 (0.113, 0.113)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC1	time		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)		18 (14, 22)
PI3K+	TC1	n		6 (5, 7)		5 (5, 5)		8 (5, 12)		4 (4, 4)		0 (0, 0)		0 (0, 1)		0 (0, 1)		2 (1, 2)		0 (0, 1)		1 (1, 1)		0 (0, 0)		2 (1, 3)		0 (0, 0)		0 (0, 1)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.82 (0.69, 0.95)		0.59 (0.59, 0.59)		0.69 (0.55, 0.83)		0.72 (0.63, 0.8)		NA (NA, NA)		0.5 (0.5, 0.5)		0.51 (0.51, 0.51)		0.54 (0.54, 0.54)		0.59 (0.59, 0.59)		0.57 (0.55, 0.6)		NA (NA, NA)		0.59 (0.58, 0.6)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.036 (0.016, 0.056)		0.027 (0.005, 0.048)		0.13 (0.094, 0.165)		0.034 (0.007, 0.06)		NA (NA, NA)		0 (0, 0)		0.209 (0.209, 0.209)		0.302 (0.195, 0.41)		0 (0, 0)		0 (0, 0)		NA (NA, NA)		0.034 (0.007, 0.062)		NA (NA, NA)		0.853 (0.853, 0.853)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC2	time		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)		18 (14, 21)
PI3K+	TC2	n		6 (3, 8)		6 (3, 8)		4 (3, 5)		2 (1, 4)		0 (0, 1)		2 (2, 3)		0 (0, 1)		0 (0, 1)		1 (1, 1)		1 (1, 1)		0 (0, 0)		4 (3, 4)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.73 (0.71, 0.74)		0.78 (0.64, 0.92)		0.54 (0.51, 0.57)		0.62 (0.6, 0.63)		NA (NA, NA)		0.54 (0.53, 0.55)		NA (NA, NA)		NA (NA, NA)		0.56 (0.53, 0.59)		0.56 (0.52, 0.6)		NA (NA, NA)		0.64 (0.6, 0.68)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.048 (0.01, 0.086)		0.011 (0.002, 0.02)		0.104 (0.099, 0.109)		0.05 (0.01, 0.091)		1.026 (1.026, 1.026)		0.038 (0.008, 0.069)		0.346 (0.346, 0.346)		0 (0, 0)		0 (0, 0)		0 (0, 0)		NA (NA, NA)		0.041 (0.008, 0.074)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	count		305		305		305		305		305		305		305		305		305		305		305		305		305		305		305		305
PI3K+	TC5	time		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)		19 (14, 28)
PI3K+	TC5	n		7 (4, 13)		3 (1, 7)		6 (3, 11)		5 (2, 9)		0 (0, 0)		1 (0, 3)		1 (0, 2)		1 (0, 3)		0 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.89 (0.72, 0.99)		0.66 (0.53, 0.88)		0.9 (0.7, 0.99)		0.78 (0.58, 0.96)		NA (NA, NA)		0.55 (0.51, 0.65)		0.56 (0.52, 0.66)		0.56 (0.51, 0.64)		0.56 (0.52, 0.69)		0.58 (0.52, 0.73)		NA (NA, NA)		0.74 (0.56, 0.92)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.55 (0.55, 0.55)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.031 (0, 0.062)		0.02 (0, 0.068)		0.037 (0, 0.084)		0.028 (0, 0.07)		0 (0, 0)		0 (0, 0.077)		0 (0, 0.117)		0 (0, 0.088)		0 (0, 0.137)		0 (0, 0.098)		0 (0, 0.255)		0.03 (0, 0.073)		0 (0, 0.102)		0.081 (0.081, 0.081)		0.119 (0, 0.346)		0 (0, 0.176)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC4	count	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8
all	TC4	time	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)
all	TC4	n	12 (6, 16)	2 (1, 4)	1 (0, 1)	0 (0, 3)	1 (0, 4)	2 (0, 3)	0 (0, 1)	2 (1, 4)	2 (0, 3)	0 (0, 0)	2 (0, 4)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	2 (1, 2)	2 (0, 3)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.29 (0.05, 0.43)	0.4 (0.34, 0.46)	0.42 (0.39, 0.45)	0.28 (0.24, 0.38)	0.42 (0.38, 0.45)	0.43 (0.34, 0.45)	0.44 (0.42, 0.45)	0.42 (0.35, 0.49)	0.45 (0.41, 0.47)	NA (NA, NA)	0.49 (0.47, 0.5)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	0.44 (0.42, 0.46)	0.39 (0.39, 0.39)	0.39 (0.39, 0.39)	NA (NA, NA)	0.38 (0.3, 0.44)	0.43 (0.38, 0.47)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.221 (0.161, 0.534)	0.269 (0.097, 0.645)	0.459 (0.266, 1.065)	0.916 (0.626, 2.501)	0.14 (0.103, 7.729)	0.435 (0.289, 0.669)	0.396 (0.058, 2.14)	0.204 (0.054, 1.17)	0.143 (0.04, 0.461)	NA (NA, NA)	0.039 (0, 0.219)	0 (0, 0)	NA (NA, NA)	0.13 (0.026, 0.234)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	9.948 (0.365, 19.788)	0.572 (0.572, 0.572)	0.145 (0.029, 0.261)	NA (NA, NA)	0.303 (0.193, 1.495)	0.22 (0.143, 0.288)	0.082 (0.016, 0.148)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
all	TC5	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC5	time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
all	TC5	n	11 (11, 11)	2 (2, 2)	2 (2, 2)	1 (1, 1)	2 (2, 2)	1 (1, 1)	1 (1, 1)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	3 (3, 3)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.4 (0.4, 0.4)	0.46 (0.46, 0.46)	0.44 (0.44, 0.44)	NA (NA, NA)	0.49 (0.49, 0.49)	0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.19 (0.19, 0.19)	0.377 (0.377, 0.377)	0.24 (0.24, 0.24)	0 (0, 0)	0 (0, 0)	0 (0, 0)	3.277 (3.277, 3.277)	NA (NA, NA)	0.39 (0.39, 0.39)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.316 (0.316, 0.316)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC2	count	101	101	101	101					101	101	101	101
AR- & TP53-	TC2	time	13 (8, 22)	13 (8, 22)	13 (8, 22)	13 (8, 22)					13 (8, 22)	13 (8, 22)	13 (8, 22)	13 (8, 22)
AR- & TP53-	TC2	n	19 (14, 30)	5 (2, 10)	0 (0, 2)	2 (0, 4)					4 (2, 9)	0 (0, 0)	2 (0, 5)	1 (0, 3)
AR- & TP53-	TC2	post_p	0.1 (0.01, 0.37)	0.37 (0.12, 0.48)	0.45 (0.37, 0.5)	0.46 (0.36, 0.5)					0.35 (0.1, 0.46)	NA (NA, NA)	0.44 (0.38, 0.48)	0.45 (0.36, 0.49)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.183 (0.125, 0.263)	0.198 (0.111, 0.408)	0.111 (0, 0.496)	0.112 (0.042, 0.359)					0.179 (0.113, 0.429)	0 (0, 0.351)	0.125 (0.029, 0.351)	0.066 (0, 0.511)
AR- & TP53-	TC3	count	31	31	31	31					31	31	31	31
AR- & TP53-	TC3	time	12 (9, 17)	12 (9, 17)	12 (9, 17)	12 (9, 17)					12 (9, 17)	12 (9, 17)	12 (9, 17)	12 (9, 17)
AR- & TP53-	TC3	n	18 (13, 26)	5 (3, 7)	1 (0, 2)	2 (0, 5)					3 (1, 7)	0 (0, 0)	1 (0, 3)	0 (0, 2)
AR- & TP53-	TC3	post_p	0.17 (0.02, 0.34)	0.35 (0.15, 0.48)	0.43 (0.38, 0.46)	0.38 (0.31, 0.44)					0.44 (0.35, 0.49)	NA (NA, NA)	0.43 (0.39, 0.48)	0.45 (0.39, 0.48)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.163 (0.127, 0.25)	0.175 (0.12, 0.365)	0.43 (0.153, 2.226)	0.2 (0.071, 0.597)					0.111 (0.059, 0.426)	NA (NA, NA)	0.144 (0.05, 0.395)	0.072 (0, 0.263)
AR- & TP53-	TC4	count	38	38	38	38					38	38	38	38
AR- & TP53-	TC4	time	11 (8, 16)	11 (8, 16)	11 (8, 16)	11 (8, 16)					11 (8, 16)	11 (8, 16)	11 (8, 16)	11 (8, 16)
AR- & TP53-	TC4	n	16 (12, 27)	4 (3, 7)	1 (0, 2)	2 (0, 4)					3 (1, 7)	0 (0, 0)	2 (0, 4)	1 (0, 1)
AR- & TP53-	TC4	post_p	0.08 (0, 0.28)	0.31 (0.12, 0.43)	0.42 (0.36, 0.46)	0.36 (0.26, 0.47)					0.45 (0.4, 0.49)	NA (NA, NA)	0.44 (0.36, 0.49)	0.47 (0.43, 0.49)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.205 (0.164, 0.318)	0.234 (0.149, 0.494)	0.28 (0.115, 2.45)	0.293 (0.132, 0.991)					0.097 (0.053, 0.33)	0 (0, 0)	0.116 (0, 0.396)	0.043 (0, 0.452)
AR- & TP53-	TC5	count	22	22	22	22					22	22	22	22
AR- & TP53-	TC5	time	12 (8, 18)	12 (8, 18)	12 (8, 18)	12 (8, 18)					12 (8, 18)	12 (8, 18)	12 (8, 18)	12 (8, 18)
AR- & TP53-	TC5	n	16 (13, 23)	4 (1, 7)	1 (0, 2)	2 (0, 4)					5 (2, 7)	0 (0, 0)	2 (0, 5)	0 (0, 4)
AR- & TP53-	TC5	post_p	0.16 (0.02, 0.33)	0.44 (0.38, 0.48)	0.43 (0.28, 0.47)	0.45 (0.34, 0.49)					0.34 (0.14, 0.48)	NA (NA, NA)	0.36 (0.21, 0.41)	0.45 (0.43, 0.49)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.183 (0.144, 0.218)	0.142 (0.09, 0.291)	0.179 (0.137, 0.585)	0.106 (0.054, 0.341)					0.202 (0.114, 0.379)	1.194 (1.194, 1.194)	0.224 (0.127, 0.77)	0.099 (0.029, 0.158)
HRD+	TC1	count									12	12	12	12	12	12	12	12									12	12	12	12	12	12	12	12
HRD+	TC1	time									28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)									28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)	28 (22, 35)
HRD+	TC1	n									12 (9, 13)	0 (0, 1)	6 (3, 8)	2 (1, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	2 (0, 4)									4 (2, 8)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.4 (0.19, 0.47)	NA (NA, NA)	0.36 (0.21, 0.46)	0.43 (0.29, 0.49)	NA (NA, NA)	0.46 (0.36, 0.49)	NA (NA, NA)	0.38 (0.27, 0.44)									0.33 (0.09, 0.43)	NA (NA, NA)	0.44 (0.43, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.11 (0.084, 0.137)	0 (0, 0)	0.12 (0.061, 0.223)	0.091 (0.073, 0.228)	NA (NA, NA)	0.171 (0.046, 0.405)	0.306 (0.306, 0.306)	0.204 (0.133, 0.609)									0.241 (0.154, 0.315)	NA (NA, NA)	0.346 (0.333, 0.465)	NA (NA, NA)	0 (0, 0)	0.083 (0.083, 0.083)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									47	47	47	47	47	47	47	47									47	47	47	47	47	47	47	47
HRD+	TC2	time									30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)									30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)
HRD+	TC2	n									12 (9, 16)	0 (0, 0)	5 (3, 9)	3 (0, 5)	0 (0, 0)	1 (0, 4)	0 (0, 0)	1 (0, 4)									4 (2, 8)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.1 (0.02, 0.3)	NA (NA, NA)	0.4 (0.23, 0.49)	0.44 (0.31, 0.49)	NA (NA, NA)	0.42 (0.3, 0.48)	NA (NA, NA)	0.45 (0.37, 0.49)									0.32 (0.17, 0.46)	NA (NA, NA)	0.45 (0.42, 0.48)	0.46 (0.46, 0.46)	0.41 (0.41, 0.41)	0.49 (0.49, 0.49)	NA (NA, NA)	0.44 (0.44, 0.44)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.188 (0.139, 0.278)	0.714 (0.121, 2.956)	0.084 (0.055, 0.227)	0.092 (0.042, 0.722)	0.188 (0.082, 0.294)	0.25 (0.122, 1.197)	0 (0, 0)	0.123 (0.046, 0.418)									0.225 (0.125, 0.423)	0.305 (0.026, 3.399)	0.107 (0.01, 1.346)	0.043 (0.009, 0.077)	0.747 (0.271, 9.339)	0.055 (0, 1.548)	0.093 (0.066, 0.12)	0.054 (0.011, 0.097)
HRD+	TC5	count									78	78	78	78	78	78	78	78									78	78	78	78	78	78	78	78
HRD+	TC5	time									30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)									30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)	30 (24, 34)
HRD+	TC5	n									12 (8, 17)	0 (0, 0)	6 (3, 10)	1 (0, 4)	0 (0, 0)	0 (0, 3)	0 (0, 0)	1 (0, 3)									4 (2, 7)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.09 (0.01, 0.26)	NA (NA, NA)	0.16 (0.04, 0.3)	0.44 (0.35, 0.49)	NA (NA, NA)	0.47 (0.41, 0.5)	NA (NA, NA)	0.44 (0.39, 0.47)									0.37 (0.14, 0.47)	NA (NA, NA)	0.45 (0.41, 0.48)	NA (NA, NA)	0.46 (0.45, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.181 (0.135, 0.282)	0.096 (0.096, 0.096)	0.212 (0.128, 0.371)	0.07 (0.039, 0.286)	1.183 (1.183, 1.183)	0.116 (0.046, 0.277)	0.063 (0, 0.393)	0.1 (0.024, 0.567)									0.22 (0.123, 0.518)	0.068 (0.068, 0.068)	0.371 (0.102, 1.589)	NA (NA, NA)	0.199 (0.072, 0.547)	0.422 (0.422, 0.422)	0.244 (0.154, 1.198)	0.105 (0.105, 0.105)
TP53+	TC1	count					105	105	105	105					105	105	105	105					105	105	105	105					105	105	105	105
TP53+	TC1	time					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)
TP53+	TC1	n					7 (4, 12)	7 (3, 12)	2 (0, 5)	6 (2, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 3)					0 (0, 1)	0 (0, 0)	6 (3, 12)	5 (2, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.37 (0.14, 0.48)	0.36 (0.14, 0.47)	0.39 (0.26, 0.48)	0.31 (0.1, 0.47)					0.44 (0.44, 0.44)	0.44 (0.37, 0.48)	0.44 (0.44, 0.44)	0.43 (0.33, 0.48)					0.45 (0.4, 0.48)	NA (NA, NA)	0.31 (0.16, 0.47)	0.36 (0.19, 0.46)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.143 (0.107, 0.252)	0.18 (0.126, 0.318)	0.193 (0.089, 0.576)	0.177 (0.105, 0.337)					0.115 (0.023, 0.262)	0.189 (0.051, 0.707)	0.135 (0.094, 6.182)	0.172 (0.083, 0.78)					0.335 (0.026, 1.93)	0.122 (0.024, 1.302)	0.155 (0.103, 0.272)	0.162 (0.114, 0.305)					0.07 (0, 0.32)	0.11 (0.11, 0.11)	0.111 (0.022, 0.187)	NA (NA, NA)
TP53+	TC2	count					1	1	1	1					1	1	1	1					1	1	1	1					1	1	1	1
TP53+	TC2	time					18 (18, 18)	18 (18, 18)	18 (18, 18)	18 (18, 18)					18 (18, 18)	18 (18, 18)	18 (18, 18)	18 (18, 18)					18 (18, 18)	18 (18, 18)	18 (18, 18)	18 (18, 18)					18 (18, 18)	18 (18, 18)	18 (18, 18)	18 (18, 18)
TP53+	TC2	n					9 (9, 9)	5 (5, 5)	2 (2, 2)	4 (4, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					1 (1, 1)	0 (0, 0)	4 (4, 4)	3 (3, 3)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.29 (0.29, 0.29)	0.21 (0.21, 0.21)	0.45 (0.45, 0.45)	0.5 (0.5, 0.5)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					0.44 (0.44, 0.44)	NA (NA, NA)	0.49 (0.49, 0.49)	0.36 (0.36, 0.36)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.182 (0.182, 0.182)	0.283 (0.283, 0.283)	0.295 (0.295, 0.295)	0.124 (0.124, 0.124)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					0.387 (0.387, 0.387)	NA (NA, NA)	0.059 (0.059, 0.059)	0.199 (0.199, 0.199)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					79	79	79	79					79	79	79	79					79	79	79	79					79	79	79	79
TP53+	TC3	time					20 (15, 31)	20 (15, 31)	20 (15, 31)	20 (15, 31)					20 (15, 31)	20 (15, 31)	20 (15, 31)	20 (15, 31)					20 (15, 31)	20 (15, 31)	20 (15, 31)	20 (15, 31)					20 (15, 31)	20 (15, 31)	20 (15, 31)	20 (15, 31)
TP53+	TC3	n					8 (4, 13)	7 (4, 11)	2 (1, 5)	5 (3, 9)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	6 (3, 11)	4 (2, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.36 (0.16, 0.48)	0.32 (0.15, 0.47)	0.39 (0.26, 0.47)	0.31 (0.1, 0.46)					0.44 (0.44, 0.44)	0.47 (0.41, 0.49)	NA (NA, NA)	0.45 (0.37, 0.5)					0.44 (0.38, 0.48)	NA (NA, NA)	0.27 (0.08, 0.45)	0.35 (0.18, 0.48)					0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.148 (0.103, 0.244)	0.175 (0.124, 0.38)	0.256 (0.12, 0.814)	0.181 (0.103, 0.307)					0 (0, 0.524)	0.087 (0, 0.278)	0 (0, 0)	0.102 (0, 0.453)					0.485 (0.06, 2.401)	0.926 (0.185, 1.667)	0.194 (0.113, 0.353)	0.167 (0.117, 0.454)					0 (0, 0.035)	0 (0, 0.163)	NA (NA, NA)	0.035 (0, 0.125)
TP53+	TC4	count					165	165	165	165					165	165	165	165					165	165	165	165					165	165	165	165
TP53+	TC4	time					20 (13, 30)	20 (13, 30)	20 (13, 30)	20 (13, 30)					20 (13, 30)	20 (13, 30)	20 (13, 30)	20 (13, 30)					20 (13, 30)	20 (13, 30)	20 (13, 30)	20 (13, 30)					20 (13, 30)	20 (13, 30)	20 (13, 30)	20 (13, 30)
TP53+	TC4	n					7 (4, 11)	6 (3, 9)	2 (0, 4)	4 (2, 7)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	5 (2, 10)	4 (2, 7)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.38 (0.19, 0.48)	0.28 (0.09, 0.45)	0.39 (0.21, 0.47)	0.26 (0.08, 0.43)					NA (NA, NA)	0.47 (0.4, 0.49)	0.42 (0.42, 0.42)	0.46 (0.38, 0.49)					0.46 (0.39, 0.48)	NA (NA, NA)	0.26 (0.07, 0.43)	0.27 (0.11, 0.45)					0.47 (0.46, 0.49)	NA (NA, NA)	NA (NA, NA)	0.45 (0.45, 0.45)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.148 (0.104, 0.254)	0.236 (0.152, 0.392)	0.314 (0.135, 1.487)	0.236 (0.142, 0.518)					0.605 (0.158, 1.052)	0.081 (0, 0.422)	0 (0, 0.282)	0.088 (0, 0.546)					0.278 (0.117, 1.298)	0.213 (0.065, 0.503)	0.237 (0.134, 0.505)	0.244 (0.119, 0.49)					0 (0, 0.259)	0 (0, 0)	0 (0, 0)	0 (0, 0.207)
TEfus+	TC1	count			23	23			23	23			23	23			23	23			23	23			23	23			23	23			23	23
TEfus+	TC1	time			24 (16, 34)	24 (16, 34)			24 (16, 34)	24 (16, 34)			24 (16, 34)	24 (16, 34)			24 (16, 34)	24 (16, 34)			24 (16, 34)	24 (16, 34)			24 (16, 34)	24 (16, 34)			24 (16, 34)	24 (16, 34)			24 (16, 34)	24 (16, 34)
TEfus+	TC1	n			1 (0, 3)	4 (1, 8)			2 (1, 5)	7 (2, 15)			2 (0, 8)	2 (0, 4)			0 (0, 1)	1 (0, 3)			1 (0, 3)	1 (0, 4)			8 (3, 10)	6 (3, 11)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.44 (0.4, 0.48)	0.4 (0.18, 0.49)			0.38 (0.19, 0.47)	0.27 (0.12, 0.47)			0.36 (0.2, 0.46)	0.41 (0.37, 0.47)			NA (NA, NA)	0.41 (0.33, 0.47)			0.42 (0.29, 0.49)	0.41 (0.32, 0.49)			0.28 (0.15, 0.39)	0.3 (0.21, 0.43)			0.44 (0.41, 0.46)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.131 (0.068, 0.594)	0.085 (0.077, 0.215)			0.235 (0.172, 0.413)	0.146 (0.099, 0.309)			0.133 (0.077, 0.362)	0.105 (0.072, 0.315)			0.467 (0.201, 8.241)	0.16 (0.077, 1.286)			0.221 (0.112, 0.564)	0.184 (0.118, 0.538)			0.167 (0.115, 0.369)	0.157 (0.109, 0.274)			0.112 (0, 0.243)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			36	36			36	36			36	36			36	36			36	36			36	36			36	36			36	36
TEfus+	TC3	time			22 (16, 30)	22 (16, 30)			22 (16, 30)	22 (16, 30)			22 (16, 30)	22 (16, 30)			22 (16, 30)	22 (16, 30)			22 (16, 30)	22 (16, 30)			22 (16, 30)	22 (16, 30)			22 (16, 30)	22 (16, 30)			22 (16, 30)	22 (16, 30)
TEfus+	TC3	n			0 (0, 2)	4 (2, 8)			2 (1, 4)	6 (3, 10)			2 (0, 6)	1 (0, 2)			0 (0, 0)	0 (0, 2)			2 (1, 5)	2 (0, 3)			7 (4, 9)	5 (2, 8)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.39 (0.21, 0.46)	0.28 (0.16, 0.42)			0.39 (0.29, 0.47)	0.29 (0.14, 0.43)			0.44 (0.33, 0.49)	0.44 (0.38, 0.47)			NA (NA, NA)	0.47 (0.39, 0.49)			0.38 (0.16, 0.47)	0.42 (0.28, 0.48)			0.24 (0.08, 0.42)	0.27 (0.08, 0.44)			0.46 (0.44, 0.47)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.309 (0.11, 1.156)	0.181 (0.103, 0.604)			0.227 (0.114, 0.629)	0.179 (0.106, 0.279)			0.101 (0.044, 0.338)	0.107 (0.005, 0.443)			NA (NA, NA)	0.099 (0.01, 0.614)			0.214 (0.122, 0.843)	0.239 (0.054, 0.428)			0.216 (0.133, 0.345)	0.199 (0.123, 0.572)			0.196 (0.129, 0.547)	0 (0, 0)			NA (NA, NA)	0.054 (0.011, 0.097)
TEfus+	TC4	count			67	67			67	67			67	67			67	67			67	67			67	67			67	67			67	67
TEfus+	TC4	time			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)
TEfus+	TC4	n			1 (0, 4)	4 (2, 8)			2 (0, 4)	5 (2, 7)			3 (0, 6)	1 (0, 3)			0 (0, 0)	0 (0, 1)			2 (1, 4)	1 (0, 3)			6 (3, 11)	4 (2, 7)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.4 (0.31, 0.46)	0.25 (0.1, 0.43)			0.42 (0.24, 0.47)	0.17 (0.05, 0.42)			0.45 (0.32, 0.49)	0.45 (0.39, 0.5)			0.48 (0.48, 0.48)	0.45 (0.4, 0.49)			0.37 (0.18, 0.48)	0.39 (0.24, 0.43)			0.2 (0.06, 0.41)	0.24 (0.09, 0.45)			0.46 (0.41, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.282 (0.144, 1.109)	0.229 (0.115, 0.573)			0.242 (0.131, 0.848)	0.289 (0.143, 0.528)			0.093 (0.052, 0.241)	0.086 (0.03, 0.219)			0.176 (0.035, 0.317)	0.109 (0, 0.207)			0.244 (0.15, 0.588)	0.343 (0.164, 1.081)			0.247 (0.151, 0.47)	0.214 (0.123, 0.408)			0 (0, 0.19)	0.05 (0.01, 0.09)			0 (0, 0)	0.102 (0.02, 0.184)
PI3K+	TC1	count		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9
PI3K+	TC1	time		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)		18 (12, 34)
PI3K+	TC1	n		4 (2, 8)		3 (2, 5)		6 (3, 12)		5 (4, 9)		0 (0, 0)		1 (0, 4)		0 (0, 1)		1 (0, 4)		0 (0, 2)		1 (0, 2)		0 (0, 0)		6 (4, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.42 (0.28, 0.5)		0.42 (0.35, 0.48)		0.39 (0.22, 0.43)		0.35 (0.24, 0.43)		NA (NA, NA)		0.43 (0.39, 0.47)		0.44 (0.39, 0.44)		0.36 (0.21, 0.46)		0.4 (0.39, 0.42)		0.49 (0.41, 0.49)		0.45 (0.45, 0.45)		0.38 (0.29, 0.45)		0.48 (0.48, 0.48)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.117 (0.1, 0.162)		0.112 (0.072, 0.221)		0.197 (0.14, 0.366)		0.142 (0.119, 0.248)		NA (NA, NA)		0.086 (0.022, 0.29)		0.325 (0.059, 0.813)		0.189 (0.084, 0.605)		1.028 (0.276, 1.163)		0.074 (0, 0.268)		0.193 (0.193, 0.193)		0.157 (0.126, 0.18)		0.394 (0.394, 0.394)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3
PI3K+	TC2	time		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)		15 (13, 25)
PI3K+	TC2	n		8 (4, 8)		1 (0, 6)		5 (4, 5)		6 (6, 7)		0 (0, 0)		2 (0, 2)		0 (0, 1)		1 (0, 2)		0 (0, 2)		0 (0, 2)		0 (0, 1)		4 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.36 (0.35, 0.38)		0.48 (0.47, 0.48)		0.28 (0.27, 0.32)		0.47 (0.36, 0.48)		NA (NA, NA)		0.41 (0.4, 0.42)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.46 (0.46, 0.46)		NA (NA, NA)		0.48 (0.33, 0.49)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.142 (0.128, 0.15)		0.193 (0.073, 0.313)		0.204 (0.199, 0.541)		0.108 (0.106, 0.123)		NA (NA, NA)		0.516 (0.226, 0.806)		0.193 (0.193, 0.193)		0.067 (0.013, 0.12)		0 (0, 0)		0.111 (0.111, 0.111)		0.203 (0.203, 0.203)		0.097 (0.084, 0.11)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	count		87		87		87		87		87		87		87		87		87		87		87		87		87		87		87		87
PI3K+	TC3	time		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)		20 (14, 30)
PI3K+	TC3	n		8 (5, 13)		4 (1, 7)		7 (3, 11)		5 (3, 9)		0 (0, 0)		1 (0, 3)		0 (0, 2)		0 (0, 2)		0 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.26 (0.07, 0.44)		0.34 (0.11, 0.46)		0.31 (0.12, 0.47)		0.32 (0.13, 0.46)		NA (NA, NA)		0.45 (0.38, 0.49)		0.46 (0.4, 0.49)		0.45 (0.41, 0.49)		0.42 (0.35, 0.48)		0.42 (0.32, 0.49)		NA (NA, NA)		0.32 (0.17, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.175 (0.118, 0.276)		0.183 (0.098, 0.481)		0.192 (0.14, 0.388)		0.165 (0.098, 0.301)		1.333 (0.419, 2.246)		0.087 (0, 0.33)		0.098 (0, 0.531)		0.106 (0, 0.475)		0.287 (0.129, 1.19)		0.25 (0.055, 1.205)		NA (NA, NA)		0.178 (0.114, 0.544)		NA (NA, NA)		NA (NA, NA)		0 (0, 0.26)		0 (0, 0)
PI3K+	TC4	count		154		154		154		154		154		154		154		154		154		154		154		154		154		154		154		154
PI3K+	TC4	time		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)		19 (13, 27)
PI3K+	TC4	n		7 (4, 11)		3 (1, 7)		6 (3, 10)		5 (2, 7)		0 (0, 0)		1 (0, 3)		0 (0, 2)		0 (0, 2)		0 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.18 (0.03, 0.35)		0.3 (0.12, 0.43)		0.27 (0.12, 0.43)		0.25 (0.09, 0.43)		NA (NA, NA)		0.46 (0.37, 0.49)		0.46 (0.41, 0.5)		0.45 (0.4, 0.5)		0.44 (0.36, 0.49)		0.41 (0.31, 0.47)		NA (NA, NA)		0.29 (0.08, 0.46)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.47 (0.47, 0.47)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.238 (0.148, 0.416)		0.228 (0.11, 0.598)		0.23 (0.153, 0.386)		0.239 (0.138, 0.481)		0 (0, 0)		0.077 (0, 0.247)		0.102 (0, 0.392)		0.105 (0, 0.54)		0.362 (0.103, 1.483)		0.362 (0.11, 1.083)		4.955 (4.955, 4.955)		0.245 (0.106, 0.461)		0 (0, 0.114)		0.05 (0.01, 0.09)		0 (0, 0.103)		0 (0, 0.207)