Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)
| signature | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.086, shape = 1.05 | scale = 0.132, shape = 1.05 | scale = 0.133, shape = 1.05 | scale = 0.178, shape = 1.05 | scale = 0.128, shape = 1.05 |
| all | summary | mean = 8.8, median = 6.3 | mean = 11.4, median = 8.2 | mean = 7.4, median = 5.3 | mean = 7.4, median = 5.3 | mean = 5.5, median = 4 | mean = 7.7, median = 5.5 |
| all | effect | af = 1, hr = 1 | af = 1.29, hr = 0.76 | af = 0.84, hr = 1.19 | af = 0.84, hr = 1.21 | af = 0.63, hr = 1.63 | af = 0.88, hr = 1.15 |
| AR- & TP53- | param | scale = 0.112, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.159, shape = 1.05 | scale = 0.132, shape = 1.05 | scale = 0.18, shape = 1.05 | scale = 0.149, shape = 1.05 |
| AR- & TP53- | summary | mean = 8.8, median = 6.3 | mean = 19.8, median = 14.2 | mean = 6.2, median = 4.4 | mean = 7.4, median = 5.3 | mean = 5.5, median = 3.9 | mean = 6.6, median = 4.7 |
| AR- & TP53- | effect | af = 1, hr = 1 | af = 2.25, hr = 0.43 | af = 0.7, hr = 1.45 | af = 0.84, hr = 1.2 | af = 0.62, hr = 1.65 | af = 0.75, hr = 1.35 |
| HRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.086, shape = 1.05 | scale = 0.135, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.153, shape = 1.05 |
| HRD+ | summary | mean = 8.8, median = 6.3 | mean = 11.4, median = 8.2 | mean = 7.2, median = 5.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 6.4, median = 4.6 |
| HRD+ | effect | af = 1, hr = 1 | af = 1.3, hr = 0.76 | af = 0.82, hr = 1.23 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.73, hr = 1.39 |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.133, shape = 1.05 | scale = 0.095, shape = 1.05 | scale = 0.14, shape = 1.05 | scale = 0.184, shape = 1.05 | scale = 0.09, shape = 1.05 |
| TP53+ | summary | mean = 8.8, median = 6.3 | mean = 7.4, median = 5.3 | mean = 10.4, median = 7.5 | mean = 7, median = 5 | mean = 5.3, median = 3.8 | mean = 10.9, median = 7.8 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.84, hr = 1.2 | af = 1.18, hr = 0.84 | af = 0.79, hr = 1.27 | af = 0.61, hr = 1.69 | af = 1.24, hr = 0.8 |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.116, shape = 1.05 | scale = 0.049, shape = 1.05 | scale = 0.135, shape = 1.05 | scale = 0.183, shape = 1.05 | scale = 0.107, shape = 1.05 |
| TEfus+ | summary | mean = 8.8, median = 6.3 | mean = 8.4, median = 6.1 | mean = 19.9, median = 14.3 | mean = 7.3, median = 5.2 | mean = 5.4, median = 3.9 | mean = 9.1, median = 6.6 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.96, hr = 1.04 | af = 2.27, hr = 0.42 | af = 0.83, hr = 1.22 | af = 0.61, hr = 1.68 | af = 1.04, hr = 0.96 |
| PI3K+ | param | scale = 0.112, shape = 1.05 | scale = 0.107, shape = 1.05 | scale = 0.117, shape = 1.05 | scale = 0.145, shape = 1.05 | scale = 0.198, shape = 1.05 | scale = 0.038, shape = 1.05 |
| PI3K+ | summary | mean = 8.8, median = 6.3 | mean = 9.2, median = 6.6 | mean = 8.4, median = 6 | mean = 6.8, median = 4.9 | mean = 5, median = 3.6 | mean = 26.1, median = 18.8 |
| PI3K+ | effect | af = 1, hr = 1 | af = 1.04, hr = 0.96 | af = 0.96, hr = 1.05 | af = 0.77, hr = 1.31 | af = 0.56, hr = 1.83 | af = 2.97, hr = 0.32 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | param | scale = 0.112, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| —– | summary | mean = 8.8, median = 6.3 | mean = 23.4, median = 16.9 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| —– | effect | af = 1, hr = 1 | af = 2.67, hr = 0.36 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| —-+ | param | scale = 0.112, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| —-+ | summary | mean = 8.8, median = 6.3 | mean = 19.4, median = 14 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| —-+ | effect | af = 1, hr = 1 | af = 2.21, hr = 0.43 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| —+- | param | scale = 0.112, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| —+- | summary | mean = 8.8, median = 6.3 | mean = 17, median = 12.2 | mean = 23.4, median = 16.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| —+- | effect | af = 1, hr = 1 | af = 1.94, hr = 0.5 | af = 2.67, hr = 0.36 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| —++ | param | scale = 0.112, shape = 1.05 | scale = 0.064, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| —++ | summary | mean = 8.8, median = 6.3 | mean = 15.4, median = 11.1 | mean = 19.4, median = 14 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| —++ | effect | af = 1, hr = 1 | af = 1.75, hr = 0.56 | af = 2.21, hr = 0.43 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| –+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| –+-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| –+-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| –++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| –++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| –++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| –+++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| –+++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 19.4, median = 14 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| –+++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.21, hr = 0.43 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| -+— | param | scale = 0.112, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -+— | summary | mean = 8.8, median = 6.3 | mean = 17, median = 12.2 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -+— | effect | af = 1, hr = 1 | af = 1.94, hr = 0.5 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -+–+ | param | scale = 0.112, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -+–+ | summary | mean = 8.8, median = 6.3 | mean = 17, median = 12.2 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -+–+ | effect | af = 1, hr = 1 | af = 1.94, hr = 0.5 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| -+-+- | param | scale = 0.112, shape = 1.05 | scale = 0.071, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -+-+- | summary | mean = 8.8, median = 6.3 | mean = 13.8, median = 9.9 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -+-+- | effect | af = 1, hr = 1 | af = 1.56, hr = 0.62 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -+-++ | param | scale = 0.112, shape = 1.05 | scale = 0.071, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -+-++ | summary | mean = 8.8, median = 6.3 | mean = 13.8, median = 9.9 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -+-++ | effect | af = 1, hr = 1 | af = 1.56, hr = 0.62 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| -++– | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -++– | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -++– | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -++-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -++-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| -+++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -+++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -+++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -++++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -++++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -++++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| +—- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +—+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +—+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +—+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| +–+- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +–+- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| +–+- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| +–++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +–++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +–++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| +-+– | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +-+– | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| +-+– | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| +-+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +-+-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +-+-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| +-++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +-++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| +-++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| +-+++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +-+++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +-+++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| ++— | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| ++— | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| ++— | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| ++–+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| ++–+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| ++–+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| ++-+- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| ++-+- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| ++-+- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| ++-++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| ++-++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| ++-++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| +++– | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +++– | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| +++– | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| +++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +++-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| +++-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| ++++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.064, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| ++++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 15.4, median = 11.1 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| ++++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.75, hr = 0.56 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| +++++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.064, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +++++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 15.4, median = 11.1 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| +++++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.75, hr = 0.56 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
|
|
|
|
|
|
| char | overall | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| err_sign | 0.084 | 0.024 | 0.044 | 0.008 | 0.000 | 0.008 |
| err_type | 0.126 | 0.030 | 0.052 | 0.008 | 0.000 | 0.040 |
| pow_sign | 0.916 | 0.372 | 0.160 | 0.368 | 0.336 | 0.610 |
| pow_type | 0.924 | 0.396 | 0.204 | 0.376 | 0.336 | 0.618 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | graduation | 0 | 10 | 4 | 1 | 0 | 0 |
| all | futility | 0 | 0 | 0 | 0 | 8 | 1 |
| all | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| all | n | 381 (359, 402) | 158 (97, 200) | 172 (113, 206) | 173 (129, 211) | 158 (117, 196) | 160 (128, 198) |
| all | n_unique | 350 (330, 368) | 142 (85, 179) | 154 (100, 187) | 156 (116, 191) | 144 (106, 180) | 145 (114, 179) |
| all | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| all | time_stop | NA (NA, NA) | 6 (5, 8) | 6 (4, 7) | 6 (6, 6) | 6 (6, 7) | 4 (4, 4) |
| all | post_p | NA (NA, NA) | 0.94 (0.49, 1) | 0.15 (0.01, 0.59) | 0.02 (0, 0.26) | 0 (0, 0.01) | 0.22 (0.02, 0.75) |
| all | rate | 0.092 (0.085, 0.101) | 0.076 (0.065, 0.093) | 0.105 (0.091, 0.119) | 0.116 (0.103, 0.13) | 0.14 (0.122, 0.158) | 0.102 (0.087, 0.117) |
| AR- & TP53- | graduation | 0 | 186 | 0 | 3 | 0 | 1 |
| AR- & TP53- | futility | 0 | 0 | 101 | 31 | 38 | 22 |
| AR- & TP53- | max_n | 0 | 1 | 3 | 17 | 16 | 9 |
| AR- & TP53- | n | 214 (195, 234) | 88 (26, 115) | 96 (30, 120) | 98 (77, 126) | 94 (69, 117) | 94 (74, 117) |
| AR- & TP53- | n_unique | 198 (180, 215) | 80 (24, 105) | 88 (28, 111) | 90 (70, 113) | 86 (61, 109) | 85 (67, 108) |
| AR- & TP53- | time_trial | 36 (36, 36) | 36 (10, 36) | 36 (13, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| AR- & TP53- | time_stop | NA (NA, NA) | 12 (9, 24) | 13 (8, 22) | 12 (9, 17) | 11 (8, 16) | 12 (8, 18) |
| AR- & TP53- | post_p | NA (NA, NA) | 1 (0.98, 1) | 0 (0, 0.04) | 0.05 (0, 0.31) | 0 (0, 0.06) | 0.01 (0, 0.16) |
| AR- & TP53- | rate | 0.084 (0.075, 0.095) | 0.048 (0.038, 0.057) | 0.139 (0.117, 0.17) | 0.112 (0.095, 0.133) | 0.138 (0.114, 0.168) | 0.124 (0.102, 0.151) |
| HRD+ | graduation | 0 | 3 | 0 | 184 | 168 | 0 |
| HRD+ | futility | 0 | 12 | 47 | 0 | 0 | 78 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 64 (55, 76) | 26 (13, 40) | 28 (16, 40) | 27 (21, 38) | 26 (18, 37) | 29 (22, 40) |
| HRD+ | n_unique | 59 (50, 69) | 23 (11, 35) | 25 (14, 36) | 24 (19, 34) | 24 (16, 33) | 26 (19, 36) |
| HRD+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (25, 36) | 36 (27, 36) | 36 (32, 36) |
| HRD+ | time_stop | NA (NA, NA) | 29 (24, 35) | 30 (24, 35) | 29 (21, 35) | 30 (23, 35) | 30 (24, 34) |
| HRD+ | post_p | NA (NA, NA) | 0.65 (0.25, 0.91) | 0.21 (0.02, 0.65) | 1 (0.94, 1) | 1 (0.93, 1) | 0.06 (0, 0.42) |
| HRD+ | rate | 0.097 (0.08, 0.116) | 0.081 (0.059, 0.113) | 0.113 (0.083, 0.161) | 0.038 (0.027, 0.053) | 0.038 (0.027, 0.054) | 0.137 (0.097, 0.182) |
| TP53+ | graduation | 0 | 0 | 21 | 0 | 0 | 19 |
| TP53+ | futility | 0 | 105 | 1 | 79 | 165 | 0 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| TP53+ | n | 133 (118, 148) | 62 (31, 80) | 63 (46, 81) | 61 (36, 80) | 52 (26, 74) | 52 (37, 71) |
| TP53+ | n_unique | 122 (108, 135) | 55 (28, 70) | 55 (41, 71) | 54 (32, 70) | 46 (24, 66) | 46 (32, 63) |
| TP53+ | time_trial | 36 (36, 36) | 36 (21, 36) | 36 (36, 36) | 36 (25, 36) | 36 (16, 36) | 36 (36, 36) |
| TP53+ | time_stop | NA (NA, NA) | 21 (13, 32) | 19 (15, 24) | 20 (15, 31) | 20 (13, 30) | 15 (14, 25) |
| TP53+ | post_p | NA (NA, NA) | 0.09 (0.01, 0.43) | 0.95 (0.65, 1) | 0.09 (0.01, 0.44) | 0.01 (0, 0.15) | 0.97 (0.71, 1) |
| TP53+ | rate | 0.104 (0.089, 0.119) | 0.135 (0.114, 0.164) | 0.077 (0.061, 0.096) | 0.134 (0.11, 0.168) | 0.165 (0.133, 0.208) | 0.072 (0.057, 0.093) |
| TEfus+ | graduation | 0 | 0 | 80 | 0 | 0 | 1 |
| TEfus+ | futility | 0 | 23 | 0 | 36 | 67 | 0 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 127 (112, 141) | 56 (34, 75) | 58 (30, 75) | 59 (39, 77) | 50 (29, 72) | 52 (38, 71) |
| TEfus+ | n_unique | 116 (103, 129) | 49 (31, 66) | 50 (27, 67) | 52 (33, 69) | 44 (26, 64) | 47 (34, 63) |
| TEfus+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (20, 36) | 36 (36, 36) | 36 (25, 36) | 36 (36, 36) |
| TEfus+ | time_stop | NA (NA, NA) | 24 (16, 34) | 19 (14, 28) | 22 (16, 30) | 22 (16, 29) | 15 (15, 15) |
| TEfus+ | post_p | NA (NA, NA) | 0.07 (0, 0.34) | 1 (0.92, 1) | 0.05 (0, 0.28) | 0.01 (0, 0.13) | 0.54 (0.13, 0.91) |
| TEfus+ | rate | 0.08 (0.071, 0.093) | 0.112 (0.094, 0.138) | 0.048 (0.038, 0.061) | 0.115 (0.094, 0.148) | 0.139 (0.108, 0.184) | 0.082 (0.064, 0.103) |
| PI3K+ | graduation | 0 | 2 | 2 | 0 | 0 | 305 |
| PI3K+ | futility | 0 | 9 | 3 | 87 | 154 | 0 |
| PI3K+ | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| PI3K+ | n | 130 (115, 144) | 58 (35, 80) | 62 (42, 83) | 62 (30, 86) | 51 (25, 76) | 40 (25, 71) |
| PI3K+ | n_unique | 119 (106, 133) | 50 (29, 71) | 55 (37, 74) | 56 (27, 77) | 46 (23, 68) | 36 (22, 64) |
| PI3K+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (21, 36) | 36 (17, 36) | 25 (15, 36) |
| PI3K+ | time_stop | NA (NA, NA) | 18 (13, 34) | 15 (13, 25) | 20 (14, 30) | 19 (13, 27) | 19 (14, 28) |
| PI3K+ | post_p | NA (NA, NA) | 0.48 (0.09, 0.89) | 0.61 (0.16, 0.94) | 0.05 (0, 0.33) | 0 (0, 0.06) | 1 (1, 1) |
| PI3K+ | rate | 0.098 (0.085, 0.113) | 0.099 (0.079, 0.127) | 0.093 (0.074, 0.118) | 0.134 (0.109, 0.164) | 0.174 (0.138, 0.225) | 0.036 (0.027, 0.047) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | graduation | 0 | 196 | 4 | 4 | 0 | 1 |
| —– | futility | 0 | 0 | 101 | 31 | 45 | 23 |
| —– | max_n | 0 | 1 | 3 | 17 | 16 | 9 |
| —– | n | 118 (105, 132) | 44 (14, 59) | 49 (18, 64) | 53 (39, 68) | 52 (36, 66) | 53 (41, 68) |
| —– | n_unique | 109 (96, 123) | 41 (14, 56) | 46 (17, 61) | 50 (37, 64) | 49 (32, 63) | 50 (38, 64) |
| —– | post_p | NA (NA, NA) | 1 (0.98, 1) | 0 (0, 0.04) | 0 (0, 0.08) | 0 (0, 0) | 0 (0, 0.01) |
| —– | rate | 0.086 (0.072, 0.101) | 0.04 (0.03, 0.053) | 0.185 (0.152, 0.226) | 0.158 (0.13, 0.195) | 0.221 (0.182, 0.263) | 0.184 (0.154, 0.223) |
| —-+ | graduation | 0 | 194 | 6 | 4 | 0 | 302 |
| —-+ | futility | 0 | 9 | 101 | 109 | 185 | 20 |
| —-+ | max_n | 0 | 1 | 3 | 17 | 16 | 7 |
| —-+ | n | 30 (23, 38) | 12 (3, 22) | 14 (5, 22) | 14 (6, 23) | 12 (5, 21) | 9 (4, 18) |
| —-+ | n_unique | 28 (21, 35) | 11 (2, 19) | 13 (4, 21) | 13 (5, 21) | 11 (4, 19) | 8 (4, 16) |
| —-+ | post_p | NA (NA, NA) | 0.93 (0.6, 1) | 0.09 (0.01, 0.33) | 0.15 (0.03, 0.42) | 0.05 (0, 0.23) | 0.98 (0.79, 1) |
| —-+ | rate | 0.093 (0.068, 0.125) | 0.049 (0.028, 0.084) | 0.188 (0.13, 0.284) | 0.158 (0.112, 0.239) | 0.228 (0.161, 0.347) | 0.036 (0.018, 0.063) |
| —+- | graduation | 0 | 189 | 82 | 2 | 0 | 2 |
| —+- | futility | 0 | 23 | 95 | 55 | 96 | 23 |
| —+- | max_n | 0 | 1 | 3 | 17 | 16 | 9 |
| —+- | n | 6 (3, 9) | 2 (0, 4) | 2 (0, 4) | 2 (0, 6) | 3 (0, 5) | 3 (1, 6) |
| —+- | n_unique | 5 (3, 9) | 2 (0, 4) | 2 (0, 4) | 2 (0, 5) | 2 (0, 5) | 3 (1, 5) |
| —+- | post_p | NA (NA, NA) | 0.59 (0.4, 0.82) | 0.64 (0.41, 0.86) | 0.38 (0.19, 0.56) | 0.32 (0.16, 0.48) | 0.36 (0.18, 0.52) |
| —+- | rate | 0.062 (0.025, 0.135) | 0.055 (0, 0.189) | 0.044 (0, 0.162) | 0.176 (0.078, 0.542) | 0.25 (0.115, 0.756) | 0.201 (0.089, 0.521) |
| —++ | graduation | 0 | 187 | 84 | 2 | 0 | 302 |
| —++ | futility | 0 | 31 | 95 | 123 | 202 | 20 |
| —++ | max_n | 0 | 1 | 3 | 17 | 16 | 7 |
| —++ | n | 14 (9, 19) | 5 (1, 11) | 6 (2, 12) | 7 (3, 13) | 6 (2, 11) | 4 (2, 9) |
| —++ | n_unique | 13 (8, 18) | 5 (1, 10) | 5 (1, 11) | 6 (2, 12) | 5 (2, 10) | 4 (1, 8) |
| —++ | post_p | NA (NA, NA) | 0.56 (0.28, 0.86) | 0.71 (0.36, 0.9) | 0.17 (0.03, 0.4) | 0.12 (0.02, 0.32) | 0.78 (0.48, 0.95) |
| —++ | rate | 0.066 (0.041, 0.108) | 0.068 (0.033, 0.133) | 0.051 (0.023, 0.116) | 0.164 (0.096, 0.309) | 0.232 (0.138, 0.458) | 0.036 (0.011, 0.085) |
| –+– | graduation | 0 | 10 | 25 | 1 | 0 | 19 |
| –+– | futility | 0 | 105 | 1 | 79 | 173 | 1 |
| –+– | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| –+– | n | 28 (21, 35) | 12 (6, 17) | 12 (7, 18) | 12 (7, 17) | 10 (5, 17) | 12 (8, 17) |
| –+– | n_unique | 25 (19, 32) | 10 (5, 15) | 11 (6, 16) | 11 (6, 16) | 9 (4, 15) | 11 (7, 16) |
| –+– | post_p | NA (NA, NA) | 0.48 (0.14, 0.85) | 0.51 (0.18, 0.84) | 0.52 (0.15, 0.86) | 0.47 (0.18, 0.83) | 0.51 (0.18, 0.83) |
| –+– | rate | 0.113 (0.086, 0.148) | 0.115 (0.072, 0.191) | 0.113 (0.076, 0.165) | 0.112 (0.075, 0.188) | 0.117 (0.076, 0.198) | 0.112 (0.076, 0.172) |
| –+-+ | graduation | 0 | 11 | 26 | 1 | 0 | 309 |
| –+-+ | futility | 0 | 111 | 4 | 121 | 230 | 1 |
| –+-+ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| –+-+ | n | 26 (20, 33) | 12 (6, 18) | 13 (8, 21) | 12 (5, 19) | 9 (4, 16) | 8 (3, 14) |
| –+-+ | n_unique | 24 (18, 31) | 10 (5, 16) | 12 (6, 19) | 10 (5, 17) | 9 (3, 15) | 7 (3, 13) |
| –+-+ | post_p | NA (NA, NA) | 0.46 (0.16, 0.83) | 0.25 (0.05, 0.61) | 0.34 (0.11, 0.74) | 0.18 (0.04, 0.43) | 0.99 (0.88, 1) |
| –+-+ | rate | 0.144 (0.11, 0.185) | 0.147 (0.092, 0.228) | 0.185 (0.125, 0.285) | 0.166 (0.109, 0.258) | 0.225 (0.159, 0.357) | 0.038 (0.018, 0.068) |
| –++- | graduation | 0 | 10 | 101 | 1 | 0 | 19 |
| –++- | futility | 0 | 120 | 1 | 106 | 205 | 1 |
| –++- | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| –++- | n | 8 (4, 12) | 4 (1, 6) | 3 (1, 6) | 4 (1, 6) | 3 (1, 6) | 4 (1, 7) |
| –++- | n_unique | 7 (4, 11) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) |
| –++- | post_p | NA (NA, NA) | 0.42 (0.21, 0.66) | 0.76 (0.48, 0.94) | 0.36 (0.16, 0.58) | 0.32 (0.14, 0.5) | 0.32 (0.16, 0.55) |
| –++- | rate | 0.083 (0.042, 0.153) | 0.15 (0.065, 0.372) | 0.037 (0, 0.118) | 0.173 (0.074, 0.445) | 0.244 (0.117, 0.682) | 0.198 (0.094, 0.446) |
| –+++ | graduation | 0 | 11 | 102 | 1 | 0 | 309 |
| –+++ | futility | 0 | 126 | 4 | 140 | 247 | 1 |
| –+++ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| –+++ | n | 20 (14, 27) | 9 (4, 15) | 9 (5, 15) | 9 (4, 15) | 7 (3, 13) | 7 (3, 13) |
| –+++ | n_unique | 18 (13, 25) | 8 (4, 13) | 8 (4, 13) | 8 (4, 14) | 6 (2, 12) | 6 (2, 12) |
| –+++ | post_p | NA (NA, NA) | 0.22 (0.05, 0.54) | 0.87 (0.55, 0.98) | 0.18 (0.04, 0.44) | 0.12 (0.02, 0.32) | 0.92 (0.66, 0.99) |
| –+++ | rate | 0.089 (0.061, 0.13) | 0.15 (0.093, 0.259) | 0.05 (0.024, 0.089) | 0.16 (0.103, 0.26) | 0.232 (0.138, 0.446) | 0.036 (0.015, 0.073) |
| -+— | graduation | 0 | 198 | 4 | 179 | 163 | 1 |
| -+— | futility | 0 | 12 | 141 | 31 | 45 | 101 |
| -+— | max_n | 0 | 1 | 2 | 16 | 15 | 9 |
| -+— | n | 26 (20, 33) | 10 (3, 17) | 12 (4, 18) | 11 (6, 17) | 11 (6, 17) | 13 (7, 19) |
| -+— | n_unique | 24 (18, 31) | 8 (2, 15) | 10 (4, 16) | 10 (5, 15) | 10 (5, 16) | 11 (6, 18) |
| -+— | post_p | NA (NA, NA) | 0.8 (0.46, 0.97) | 0.08 (0.01, 0.31) | 0.95 (0.71, 1) | 0.95 (0.72, 1) | 0.07 (0, 0.26) |
| -+— | rate | 0.098 (0.07, 0.134) | 0.056 (0.032, 0.098) | 0.186 (0.133, 0.301) | 0.038 (0.02, 0.069) | 0.04 (0.021, 0.067) | 0.188 (0.132, 0.275) |
| -+–+ | graduation | 0 | 196 | 5 | 177 | 160 | 253 |
| -+–+ | futility | 0 | 21 | 140 | 95 | 153 | 96 |
| -+–+ | max_n | 0 | 1 | 3 | 16 | 15 | 7 |
| -+–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | post_p | NA (NA, NA) | 0.52 (0.45, 0.55) | 0.51 (0.5, 0.52) | 0.49 (0.49, 0.49) | 0.52 (0.49, 0.55) | 0.49 (0.49, 0.49) |
| -+–+ | rate | 0.167 (0, 0.864) | 0.04 (0, 0.45) | 0.285 (0.047, 2.196) | 0 (0, 0.258) | 0.044 (0, 0.678) | 0.043 (0, 1.341) |
| -+-+- | graduation | 0 | 191 | 78 | 175 | 163 | 2 |
| -+-+- | futility | 0 | 35 | 135 | 54 | 94 | 101 |
| -+-+- | max_n | 0 | 1 | 2 | 16 | 15 | 9 |
| -+-+- | n | 13 (8, 18) | 5 (1, 9) | 5 (1, 9) | 6 (2, 10) | 6 (2, 10) | 7 (3, 11) |
| -+-+- | n_unique | 12 (8, 17) | 4 (1, 9) | 4 (1, 8) | 5 (2, 9) | 5 (2, 9) | 6 (3, 10) |
| -+-+- | post_p | NA (NA, NA) | 0.5 (0.2, 0.76) | 0.57 (0.3, 0.84) | 0.76 (0.46, 0.93) | 0.74 (0.42, 0.95) | 0.12 (0.02, 0.3) |
| -+-+- | rate | 0.073 (0.044, 0.116) | 0.073 (0.036, 0.153) | 0.059 (0.024, 0.149) | 0.038 (0.015, 0.082) | 0.039 (0.016, 0.092) | 0.202 (0.116, 0.37) |
| -+-++ | graduation | 0 | 189 | 79 | 173 | 160 | 253 |
| -+-++ | futility | 0 | 43 | 134 | 109 | 168 | 96 |
| -+-++ | max_n | 0 | 1 | 3 | 16 | 15 | 7 |
| -+-++ | n | 5 (3, 9) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) |
| -+-++ | n_unique | 5 (2, 8) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) | 2 (0, 4) | 2 (0, 4) |
| -+-++ | post_p | NA (NA, NA) | 0.45 (0.28, 0.63) | 0.49 (0.32, 0.68) | 0.57 (0.39, 0.78) | 0.56 (0.39, 0.76) | 0.56 (0.38, 0.75) |
| -+-++ | rate | 0.073 (0.036, 0.163) | 0.078 (0.024, 0.238) | 0.063 (0, 0.192) | 0.037 (0, 0.119) | 0.043 (0, 0.139) | 0.041 (0, 0.134) |
| -++– | graduation | 0 | 13 | 23 | 176 | 166 | 16 |
| -++– | futility | 0 | 113 | 48 | 69 | 129 | 79 |
| -++– | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| -++– | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | post_p | NA (NA, NA) | 0.46 (0.4, 0.52) | 0.49 (0.42, 0.62) | 0.44 (0.41, 0.47) | 0.45 (0.44, 0.47) | 0.5 (0.44, 0.54) |
| -++– | rate | 0.129 (0, 1.059) | 0.115 (0.008, 0.672) | 0.232 (0, 1.526) | 0.051 (0, 0.19) | 0.048 (0, 0.513) | 0.244 (0, 1.347) |
| -++-+ | graduation | 0 | 14 | 23 | 175 | 163 | 260 |
| -++-+ | futility | 0 | 119 | 49 | 104 | 173 | 77 |
| -++-+ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| -++-+ | n | 3 (1, 6) | 1 (0, 4) | 2 (0, 4) | 1 (0, 4) | 1 (0, 3) | 1 (0, 3) |
| -++-+ | n_unique | 3 (1, 6) | 1 (0, 3) | 1 (0, 4) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| -++-+ | post_p | NA (NA, NA) | 0.44 (0.33, 0.6) | 0.42 (0.28, 0.55) | 0.62 (0.43, 0.81) | 0.6 (0.43, 0.79) | 0.58 (0.43, 0.75) |
| -++-+ | rate | 0.157 (0.07, 0.384) | 0.158 (0.048, 0.571) | 0.196 (0.062, 0.769) | 0.035 (0, 0.175) | 0.041 (0, 0.216) | 0.044 (0, 0.199) |
| -+++- | graduation | 0 | 13 | 95 | 174 | 166 | 16 |
| -+++- | futility | 0 | 128 | 48 | 96 | 160 | 79 |
| -+++- | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| -+++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | post_p | NA (NA, NA) | 0.44 (0.43, 0.45) | 0.49 (0.47, 0.51) | 0.57 (0.57, 0.57) | 0.54 (0.49, 0.57) | 0.53 (0.5, 0.55) |
| -+++- | rate | 0.175 (0, 1.025) | 0.158 (0, 0.473) | 0.072 (0, 0.545) | 0 (0, 0.222) | 0.121 (0, 0.693) | 0.121 (0, 0.381) |
| -++++ | graduation | 0 | 14 | 95 | 173 | 163 | 260 |
| -++++ | futility | 0 | 134 | 49 | 123 | 189 | 77 |
| -++++ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| -++++ | n | 3 (1, 6) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 1 (0, 3) | 1 (0, 3) |
| -++++ | n_unique | 3 (1, 6) | 2 (0, 4) | 1 (0, 4) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| -++++ | post_p | NA (NA, NA) | 0.41 (0.25, 0.53) | 0.52 (0.38, 0.71) | 0.56 (0.41, 0.74) | 0.56 (0.42, 0.75) | 0.56 (0.4, 0.71) |
| -++++ | rate | 0.106 (0.036, 0.275) | 0.165 (0.054, 0.56) | 0.062 (0, 0.263) | 0.042 (0, 0.176) | 0.038 (0, 0.191) | 0.046 (0, 0.178) |
| +—- | graduation | 0 | 10 | 4 | 1 | 0 | 0 |
| +—- | futility | 0 | 0 | 0 | 0 | 8 | 1 |
| +—- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—- | n | 6 (3, 10) | 2 (1, 5) | 2 (1, 5) | 2 (1, 5) | 3 (1, 5) | 3 (1, 5) |
| +—- | n_unique | 5 (3, 9) | 2 (0, 4) | 2 (1, 4) | 2 (0, 4) | 2 (0, 4) | 2 (1, 4) |
| +—- | post_p | NA (NA, NA) | 0.47 (0.25, 0.74) | 0.49 (0.29, 0.73) | 0.49 (0.27, 0.74) | 0.5 (0.31, 0.74) | 0.51 (0.29, 0.73) |
| +—- | rate | 0.119 (0.061, 0.232) | 0.127 (0.036, 0.433) | 0.12 (0.042, 0.391) | 0.12 (0.04, 0.359) | 0.118 (0.032, 0.341) | 0.114 (0.038, 0.32) |
| +—+ | graduation | 0 | 12 | 6 | 1 | 0 | 305 |
| +—+ | futility | 0 | 9 | 3 | 87 | 162 | 1 |
| +—+ | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| +—+ | n | 2 (1, 5) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) |
| +—+ | n_unique | 2 (1, 5) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) |
| +—+ | post_p | NA (NA, NA) | 0.48 (0.37, 0.67) | 0.46 (0.33, 0.62) | 0.48 (0.34, 0.65) | 0.45 (0.32, 0.61) | 0.61 (0.44, 0.79) |
| +—+ | rate | 0.155 (0.064, 0.505) | 0.152 (0, 0.638) | 0.222 (0.062, 0.776) | 0.166 (0.031, 0.912) | 0.25 (0.066, 1.041) | 0.054 (0, 0.243) |
| +–+- | graduation | 0 | 10 | 84 | 1 | 0 | 1 |
| +–+- | futility | 0 | 23 | 0 | 36 | 75 | 1 |
| +–+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +–+- | n | 9 (5, 13) | 4 (1, 7) | 3 (1, 6) | 4 (2, 7) | 4 (1, 7) | 4 (2, 7) |
| +–+- | n_unique | 8 (5, 12) | 3 (1, 6) | 3 (1, 6) | 4 (1, 6) | 3 (1, 6) | 3 (1, 6) |
| +–+- | post_p | NA (NA, NA) | 0.41 (0.18, 0.64) | 0.79 (0.52, 0.96) | 0.37 (0.15, 0.62) | 0.3 (0.12, 0.49) | 0.32 (0.13, 0.55) |
| +–+- | rate | 0.085 (0.046, 0.147) | 0.154 (0.07, 0.383) | 0.041 (0, 0.097) | 0.167 (0.084, 0.424) | 0.231 (0.114, 0.563) | 0.207 (0.101, 0.448) |
| +–++ | graduation | 0 | 12 | 86 | 1 | 0 | 305 |
| +–++ | futility | 0 | 31 | 3 | 107 | 186 | 1 |
| +–++ | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| +–++ | n | 4 (2, 8) | 2 (0, 5) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 1 (0, 3) |
| +–++ | n_unique | 4 (2, 7) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 1 (0, 4) | 1 (0, 3) |
| +–++ | post_p | NA (NA, NA) | 0.44 (0.27, 0.6) | 0.58 (0.39, 0.8) | 0.42 (0.27, 0.6) | 0.38 (0.21, 0.53) | 0.64 (0.45, 0.84) |
| +–++ | rate | 0.102 (0.047, 0.247) | 0.148 (0.06, 0.439) | 0.065 (0, 0.245) | 0.177 (0.065, 0.645) | 0.253 (0.09, 0.849) | 0.041 (0, 0.143) |
| +-+– | graduation | 0 | 10 | 25 | 1 | 0 | 19 |
| +-+– | futility | 0 | 105 | 1 | 79 | 173 | 1 |
| +-+– | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| +-+– | n | 2 (0, 4) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | n_unique | 2 (0, 4) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | post_p | NA (NA, NA) | 0.5 (0.39, 0.65) | 0.48 (0.35, 0.63) | 0.51 (0.36, 0.66) | 0.46 (0.37, 0.59) | 0.48 (0.35, 0.62) |
| +-+– | rate | 0.177 (0.048, 0.555) | 0.167 (0, 0.803) | 0.22 (0.053, 1.045) | 0.178 (0, 1.017) | 0.262 (0.088, 1.184) | 0.215 (0, 1.008) |
| +-+-+ | graduation | 0 | 11 | 26 | 1 | 0 | 309 |
| +-+-+ | futility | 0 | 111 | 4 | 121 | 230 | 1 |
| +-+-+ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| +-+-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | post_p | NA (NA, NA) | 0.5 (0.5, 0.52) | 0.53 (0.53, 0.53) | 0.45 (0.45, 0.45) | 0.48 (0.48, 0.48) | NA (NA, NA) |
| +-+-+ | rate | 0.142 (0, 1.576) | 0.126 (0, 0.753) | 0.348 (0.124, 1.292) | 0.178 (0, 1.135) | 0.307 (0.119, 1.426) | 0.055 (0, 0.138) |
| +-++- | graduation | 0 | 10 | 101 | 1 | 0 | 19 |
| +-++- | futility | 0 | 120 | 1 | 106 | 205 | 1 |
| +-++- | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| +-++- | n | 22 (17, 29) | 10 (5, 14) | 9 (5, 15) | 9 (5, 14) | 8 (3, 14) | 11 (6, 16) |
| +-++- | n_unique | 21 (15, 27) | 8 (4, 13) | 8 (4, 14) | 8 (4, 13) | 7 (3, 13) | 10 (5, 14) |
| +-++- | post_p | NA (NA, NA) | 0.27 (0.08, 0.62) | 0.96 (0.75, 1) | 0.2 (0.04, 0.47) | 0.11 (0.02, 0.31) | 0.11 (0.02, 0.42) |
| +-++- | rate | 0.082 (0.059, 0.118) | 0.14 (0.093, 0.235) | 0.038 (0.018, 0.071) | 0.172 (0.11, 0.277) | 0.232 (0.15, 0.418) | 0.19 (0.122, 0.284) |
| +-+++ | graduation | 0 | 11 | 102 | 1 | 0 | 309 |
| +-+++ | futility | 0 | 126 | 4 | 140 | 247 | 1 |
| +-+++ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| +-+++ | n | 17 (12, 23) | 8 (3, 14) | 8 (4, 14) | 8 (3, 13) | 6 (2, 12) | 5 (2, 11) |
| +-+++ | n_unique | 16 (11, 21) | 7 (3, 12) | 7 (3, 12) | 7 (3, 12) | 5 (2, 10) | 5 (2, 10) |
| +-+++ | post_p | NA (NA, NA) | 0.29 (0.09, 0.61) | 0.82 (0.46, 0.97) | 0.24 (0.06, 0.49) | 0.16 (0.03, 0.38) | 0.9 (0.65, 0.99) |
| +-+++ | rate | 0.099 (0.067, 0.141) | 0.147 (0.09, 0.252) | 0.059 (0.031, 0.108) | 0.164 (0.107, 0.301) | 0.238 (0.139, 0.405) | 0.037 (0.013, 0.078) |
| ++— | graduation | 0 | 13 | 4 | 185 | 168 | 0 |
| ++— | futility | 0 | 12 | 47 | 0 | 8 | 79 |
| ++— | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++— | n | 9 (6, 14) | 4 (2, 7) | 4 (2, 7) | 4 (2, 7) | 4 (1, 7) | 4 (2, 7) |
| ++— | n_unique | 9 (5, 13) | 3 (1, 6) | 4 (1, 7) | 3 (1, 6) | 3 (1, 6) | 4 (1, 6) |
| ++— | post_p | NA (NA, NA) | 0.44 (0.22, 0.68) | 0.33 (0.14, 0.57) | 0.84 (0.55, 0.97) | 0.83 (0.58, 0.96) | 0.33 (0.15, 0.57) |
| ++— | rate | 0.149 (0.095, 0.251) | 0.146 (0.072, 0.326) | 0.21 (0.102, 0.48) | 0.038 (0, 0.105) | 0.041 (0, 0.097) | 0.197 (0.096, 0.475) |
| ++–+ | graduation | 0 | 15 | 5 | 183 | 165 | 256 |
| ++–+ | futility | 0 | 21 | 48 | 72 | 130 | 77 |
| ++–+ | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| ++–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | post_p | NA (NA, NA) | 0.48 (0.45, 0.52) | 0.52 (0.49, 0.55) | 0.57 (0.57, 0.57) | 0.51 (0.48, 0.54) | 0.56 (0.56, 0.56) |
| ++–+ | rate | 0.201 (0.037, 0.738) | 0.312 (0.022, 1.218) | 0.305 (0.013, 3.712) | 0.066 (0, 0.537) | 0.047 (0, 0.293) | 0 (0, 0.256) |
| ++-+- | graduation | 0 | 13 | 80 | 183 | 168 | 1 |
| ++-+- | futility | 0 | 35 | 47 | 35 | 73 | 79 |
| ++-+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++-+- | n | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) |
| ++-+- | n_unique | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 2) | 0 (0, 1) |
| ++-+- | post_p | NA (NA, NA) | 0.47 (0.39, 0.58) | 0.54 (0.43, 0.65) | 0.55 (0.42, 0.64) | 0.54 (0.44, 0.63) | 0.44 (0.36, 0.54) |
| ++-+- | rate | 0.121 (0, 0.444) | 0.149 (0, 0.625) | 0.05 (0, 0.305) | 0.021 (0, 0.214) | 0.026 (0, 0.23) | 0.243 (0, 1.178) |
| ++-++ | graduation | 0 | 15 | 81 | 181 | 165 | 256 |
| ++-++ | futility | 0 | 43 | 48 | 92 | 152 | 77 |
| ++-++ | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| ++-++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | post_p | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.48 (0.48, 0.48) | 0.57 (0.54, 0.61) | 0.55 (0.55, 0.55) | 0.51 (0.44, 0.59) |
| ++-++ | rate | 0.248 (0, 1.234) | 0.283 (0.101, 1.32) | 0.083 (0, 0.248) | 0.036 (0, 0.234) | 0.016 (0, 0.126) | 0.093 (0, 0.22) |
| +++– | graduation | 0 | 13 | 23 | 176 | 166 | 16 |
| +++– | futility | 0 | 113 | 48 | 69 | 129 | 79 |
| +++– | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| +++– | n | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | n_unique | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) |
| +++– | post_p | NA (NA, NA) | 0.53 (0.45, 0.58) | 0.46 (0.41, 0.57) | 0.55 (0.48, 0.6) | 0.54 (0.51, 0.62) | 0.48 (0.43, 0.57) |
| +++– | rate | 0.207 (0.047, 1.078) | 0.147 (0, 0.734) | 0.255 (0, 1.371) | 0 (0, 0.2) | 0.042 (0, 0.422) | 0.242 (0, 1.094) |
| +++-+ | graduation | 0 | 14 | 23 | 175 | 163 | 260 |
| +++-+ | futility | 0 | 119 | 49 | 104 | 173 | 77 |
| +++-+ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| +++-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | post_p | NA (NA, NA) | 0.55 (0.54, 0.56) | 0.5 (0.47, 0.55) | 0.54 (0.46, 0.58) | 0.54 (0.54, 0.54) | 0.52 (0.51, 0.54) |
| +++-+ | rate | 0.163 (0, 0.943) | 0.071 (0, 0.877) | 0.288 (0, 1.242) | 0 (0, 0.154) | 0 (0, 0.081) | 0.057 (0, 0.344) |
| ++++- | graduation | 0 | 13 | 95 | 174 | 166 | 16 |
| ++++- | futility | 0 | 128 | 48 | 96 | 160 | 79 |
| ++++- | max_n | 0 | 0 | 0 | 0 | 1 | 0 |
| ++++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | post_p | NA (NA, NA) | 0.46 (0.42, 0.5) | 0.52 (0.48, 0.55) | 0.52 (0.5, 0.54) | NA (NA, NA) | NA (NA, NA) |
| ++++- | rate | 0.088 (0, 0.293) | 0.115 (0, 0.607) | 0.099 (0, 0.621) | 0.076 (0, 0.653) | 0 (0, 0.146) | 0.192 (0.026, 0.352) |
| +++++ | graduation | 0 | 14 | 95 | 173 | 163 | 260 |
| +++++ | futility | 0 | 134 | 49 | 123 | 189 | 77 |
| +++++ | max_n | 0 | 0 | 1 | 0 | 1 | 0 |
| +++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | post_p | NA (NA, NA) | 0.46 (0.42, 0.49) | 0.58 (0.51, 0.6) | 0.48 (0.48, 0.48) | 0.49 (0.48, 0.5) | 0.68 (0.68, 0.68) |
| +++++ | rate | 0.132 (0, 0.923) | 0.063 (0, 0.453) | 0 (0, 0.295) | 0 (0, 0.167) | 0.064 (0, 0.658) | 0.022 (0, 0.148) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| all | count | 10 | 4 | 1 | ||
| all | time_stop | 6 (5, 8) | 6 (4, 7) | 6 (6, 6) | ||
| all | n_trt | 30 (25, 32) | 29 (26, 34) | 25 (25, 25) | ||
| all | n_control | 50 (35, 74) | 48 (34, 56) | 49 (49, 49) | ||
| all | post_p | 0.93 (0.88, 1) | 0.95 (0.93, 0.96) | 0.89 (0.89, 0.89) | ||
| all | order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | ||
| AR- & TP53- | count | 186 | 3 | 1 | ||
| AR- & TP53- | time_stop | 12 (9, 24) | 7 (6, 12) | 11 (11, 11) | ||
| AR- & TP53- | n_trt | 30 (25, 64) | 28 (26, 28) | 25 (25, 25) | ||
| AR- & TP53- | n_control | 69 (44, 150) | 43 (25, 73) | 64 (64, 64) | ||
| AR- & TP53- | post_p | 0.99 (0.95, 1) | 0.9 (0.89, 0.94) | 0.96 (0.96, 0.96) | ||
| AR- & TP53- | order | 1 (1, 2) | 1 (1, 1) | 1 (1, 1) | ||
| HRD+ | count | 3 | 184 | 168 | ||
| HRD+ | time_stop | 32 (30, 32) | 29 (21, 35) | 30 (23, 35) | ||
| HRD+ | n_trt | 29 (26, 31) | 26 (25, 32) | 26 (25, 31) | ||
| HRD+ | n_control | 56 (52, 66) | 50 (36, 66) | 53 (38, 68) | ||
| HRD+ | post_p | 0.94 (0.93, 0.94) | 1 (0.98, 1) | 1 (0.98, 1) | ||
| HRD+ | order | 2 (1.2, 2.8) | 2 (1, 3) | 2 (1, 4) | ||
| TP53+ | count | 21 | 19 | |||
| TP53+ | time_stop | 20 (15, 24) | 15 (14, 25) | |||
| TP53+ | n_trt | 29 (25, 38) | 26 (25, 36) | |||
| TP53+ | n_control | 70 (49, 97) | 53 (39, 77) | |||
| TP53+ | post_p | 0.98 (0.94, 1) | 0.98 (0.96, 1) | |||
| TP53+ | order | 2 (1, 3) | 1 (1, 2.2) | |||
| TEfus+ | count | 80 | 1 | |||
| TEfus+ | time_stop | 19 (14, 28) | 15 (15, 15) | |||
| TEfus+ | n_trt | 30 (25, 51) | 30 (30, 30) | |||
| TEfus+ | n_control | 62 (43, 100) | 41 (41, 41) | |||
| TEfus+ | post_p | 0.99 (0.96, 1) | 0.98 (0.98, 0.98) | |||
| TEfus+ | order | 2 (1, 3) | 2 (2, 2) | |||
| PI3K+ | count | 2 | 2 | 305 | ||
| PI3K+ | time_stop | 18 (14, 22) | 18 (14, 21) | 19 (14, 28) | ||
| PI3K+ | n_trt | 30 (26, 34) | 27 (26, 28) | 28 (25, 52) | ||
| PI3K+ | n_control | 57 (45, 69) | 61 (45, 77) | 64 (46, 102) | ||
| PI3K+ | post_p | 0.98 (0.96, 0.99) | 0.95 (0.92, 0.98) | 1 (0.99, 1) | ||
| PI3K+ | order | 2.5 (2.1, 2.9) | 2.5 (2.1, 2.9) | 1 (1, 2) |
| signature | var | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| all | count | 8 | 1 | |||
| all | time_stop | 6 (6, 7) | 4 (4, 4) | |||
| all | n_trt | 34 (25, 36) | 28 (28, 28) | |||
| all | n_control | 52 (45, 74) | 34 (34, 34) | |||
| all | post_p | 0.01 (0, 0.2) | 0.08 (0.08, 0.08) | |||
| all | order | 1 (1, 1) | 1 (1, 1) | |||
| AR- & TP53- | count | 101 | 31 | 38 | 22 | |
| AR- & TP53- | time_stop | 13 (8, 22) | 12 (9, 17) | 11 (8, 16) | 12 (8, 18) | |
| AR- & TP53- | n_trt | 31 (25, 55) | 29 (25, 42) | 27 (25, 43) | 30 (26, 47) | |
| AR- & TP53- | n_control | 72 (40, 134) | 61 (49, 97) | 58 (40, 101) | 66 (36, 101) | |
| AR- & TP53- | post_p | 0.03 (0, 0.16) | 0.05 (0, 0.16) | 0.02 (0, 0.1) | 0.05 (0.01, 0.16) | |
| AR- & TP53- | order | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | |
| HRD+ | count | 12 | 47 | 78 | ||
| HRD+ | time_stop | 28 (22, 35) | 30 (24, 35) | 30 (24, 34) | ||
| HRD+ | n_trt | 27 (25, 30) | 27 (25, 35) | 26 (25, 33) | ||
| HRD+ | n_control | 48 (36, 63) | 52 (42, 67) | 52 (38, 63) | ||
| HRD+ | post_p | 0.09 (0.04, 0.19) | 0.04 (0, 0.21) | 0.02 (0, 0.14) | ||
| HRD+ | order | 2 (1, 4) | 2 (1, 4) | 2 (1, 4) | ||
| TP53+ | count | 105 | 1 | 79 | 165 | |
| TP53+ | time_stop | 21 (13, 32) | 18 (18, 18) | 20 (15, 31) | 20 (13, 30) | |
| TP53+ | n_trt | 36 (26, 54) | 28 (28, 28) | 34 (25, 57) | 28 (25, 44) | |
| TP53+ | n_control | 76 (44, 114) | 63 (63, 63) | 76 (48, 117) | 71 (47, 111) | |
| TP53+ | post_p | 0.04 (0.01, 0.14) | 0.06 (0.06, 0.06) | 0.04 (0, 0.13) | 0.02 (0, 0.07) | |
| TP53+ | order | 2 (1, 4) | 1 (1, 1) | 2 (1, 4) | 2 (1, 4) | |
| TEfus+ | count | 23 | 36 | 67 | ||
| TEfus+ | time_stop | 24 (16, 34) | 22 (16, 30) | 22 (16, 29) | ||
| TEfus+ | n_trt | 35 (26, 58) | 31 (26, 43) | 31 (25, 43) | ||
| TEfus+ | n_control | 92 (56, 121) | 82 (46, 110) | 75 (50, 104) | ||
| TEfus+ | post_p | 0.01 (0, 0.09) | 0.01 (0, 0.06) | 0 (0, 0.05) | ||
| TEfus+ | order | 3 (1, 5) | 2 (1, 4) | 2 (1, 4) | ||
| PI3K+ | count | 9 | 3 | 87 | 154 | |
| PI3K+ | time_stop | 18 (12, 34) | 15 (13, 25) | 20 (14, 30) | 19 (13, 27) | |
| PI3K+ | n_trt | 28 (25, 50) | 27 (26, 33) | 29 (25, 51) | 27 (25, 43) | |
| PI3K+ | n_control | 71 (41, 118) | 50 (42, 103) | 70 (47, 104) | 67 (44, 102) | |
| PI3K+ | post_p | 0.08 (0.04, 0.23) | 0.12 (0.09, 0.18) | 0.04 (0, 0.13) | 0.01 (0, 0.07) | |
| PI3K+ | order | 2 (1, 3) | 2 (2, 2.8) | 2 (1, 4) | 2 (1, 3.7) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| all | TC1 | time | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) |
| all | TC1 | n | 11 (6, 13) | 4 (1, 4) | 1 (0, 1) | 1 (0, 4) | 2 (1, 3) | 2 (0, 4) | 0 (0, 1) | 2 (0, 2) | 2 (1, 4) | 0 (0, 0) | 0 (0, 2) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 2 (0, 3) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.93 (0.64, 0.96) | 0.54 (0.5, 0.61) | 0.54 (0.51, 0.61) | 0.53 (0.51, 0.57) | 0.54 (0.51, 0.65) | 0.54 (0.53, 0.62) | 0.53 (0.52, 0.54) | 0.58 (0.53, 0.66) | 0.53 (0.52, 0.57) | NA (NA, NA) | 0.5 (0.5, 0.54) | 0.54 (0.53, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.54 (0.54, 0.54) | 0.54 (0.52, 0.6) | NA (NA, NA) | 0.51 (0.5, 0.55) | 0.55 (0.55, 0.55) | NA (NA, NA) | NA (NA, NA) | 0.59 (0.53, 0.64) | 0.57 (0.53, 0.61) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.027 (0, 0.049) | 0.031 (0, 0.115) | 0 (0, 0.097) | 0 (0, 0) | 0 (0, 0.067) | 0.022 (0, 0.148) | 0 (0, 0) | 0 (0, 0.031) | 0 (0, 0.076) | NA (NA, NA) | 0 (0, 0.143) | 0 (0, 1.286) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.124) | 0.426 (0.426, 0.426) | 0 (0, 0.085) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0.15) | 0 (0, 0.503) | 0 (0, 0.601) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| all | TC2 | time | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) |
| all | TC2 | n | 9 (5, 12) | 2 (0, 4) | 0 (0, 1) | 0 (0, 2) | 2 (2, 3) | 2 (1, 4) | 0 (0, 1) | 0 (0, 1) | 2 (1, 3) | 0 (0, 0) | 2 (1, 3) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 1 (0, 1) | 0 (0, 0) | 0 (0, 0) | 3 (2, 5) | 2 (1, 2) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.63 (0.53, 0.68) | 0.53 (0.51, 0.56) | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.62 (0.58, 0.67) | 0.56 (0.55, 0.58) | 0.54 (0.53, 0.56) | 0.53 (0.53, 0.53) | 0.54 (0.51, 0.54) | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.54 (0.54, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | 0.55 (0.54, 0.55) | 0.55 (0.55, 0.55) | 0.55 (0.54, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.09 (0.023, 0.117) | 0 (0, 0.088) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.065) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.859) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0.03) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| all | TC3 | time | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) |
| all | TC3 | n | 5 (5, 5) | 6 (6, 6) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.64 (0.64, 0.64) | 0.6 (0.6, 0.6) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.6 (0.6, 0.6) | 0.56 (0.56, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.55 (0.55, 0.55) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.058 (0.058, 0.058) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.086 (0.086, 0.086) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.128 (0.128, 0.128) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| AR- & TP53- | TC1 | count | 186 | 186 | 186 | 186 | 186 | 186 | 186 | 186 | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | time | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | n | 17 (13, 34) | 5 (2, 10) | 1 (0, 2) | 2 (0, 5) | 4 (2, 9) | 0 (0, 0) | 2 (0, 5) | 1 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | post_p | 0.97 (0.86, 1) | 0.72 (0.55, 0.93) | 0.56 (0.51, 0.72) | 0.55 (0.51, 0.72) | 0.66 (0.53, 0.87) | 0.52 (0.52, 0.52) | 0.55 (0.51, 0.65) | 0.54 (0.51, 0.61) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | rate | 0.037 (0.013, 0.066) | 0.032 (0, 0.08) | 0 (0, 0.084) | 0.036 (0, 0.088) | 0.029 (0, 0.081) | 0.143 (0.029, 0.258) | 0 (0, 0.074) | 0 (0, 0.213) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 7 (6, 12) | 7 (6, 12) | 7 (6, 12) | 7 (6, 12) | 7 (6, 12) | 7 (6, 12) | 7 (6, 12) | 7 (6, 12) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 16 (14, 18) | 3 (1, 5) | 1 (1, 1) | 1 (0, 3) | 5 (3, 5) | 0 (0, 0) | 1 (1, 2) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.79 (0.73, 0.87) | 0.61 (0.57, 0.64) | 0.52 (0.51, 0.53) | 0.52 (0.51, 0.53) | 0.67 (0.58, 0.69) | NA (NA, NA) | 0.52 (0.52, 0.57) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.072 (0.067, 0.077) | 0 (0, 0.167) | 0 (0, 0) | 0.048 (0.01, 0.087) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 12 (12, 12) | 8 (8, 8) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.83 (0.83, 0.83) | 0.77 (0.77, 0.77) | NA (NA, NA) | 0.54 (0.54, 0.54) | 0.56 (0.56, 0.56) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.122 (0.122, 0.122) | 0.05 (0.05, 0.05) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0.048 (0.048, 0.048) | ||||||||||||||||||||||||
| HRD+ | TC1 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||
| HRD+ | TC1 | time | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | 32 (30, 32) | ||||||||||||||||
| HRD+ | TC1 | n | 14 (13, 14) | 0 (0, 0) | 6 (5, 8) | 4 (2, 5) | 0 (0, 0) | 2 (0, 3) | 0 (0, 0) | 1 (0, 1) | 3 (1, 4) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | post_p | 0.84 (0.75, 0.86) | NA (NA, NA) | 0.76 (0.68, 0.76) | 0.59 (0.58, 0.59) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | 0.59 (0.54, 0.64) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | rate | 0.054 (0.046, 0.057) | NA (NA, NA) | 0.044 (0.032, 0.054) | 0.053 (0.011, 0.057) | NA (NA, NA) | 0.052 (0.01, 0.093) | NA (NA, NA) | 0.115 (0.023, 0.207) | 0.097 (0.078, 0.116) | NA (NA, NA) | 0.078 (0.078, 0.078) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC3 | count | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | 184 | ||||||||||||||||
| HRD+ | TC3 | time | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | ||||||||||||||||
| HRD+ | TC3 | n | 11 (7, 15) | 0 (0, 0) | 5 (3, 8) | 2 (0, 5) | 0 (0, 0) | 2 (0, 3) | 0 (0, 0) | 2 (0, 4) | 3 (1, 6) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC3 | post_p | 0.94 (0.75, 0.99) | 0.5 (0.5, 0.5) | 0.75 (0.61, 0.9) | 0.59 (0.52, 0.76) | NA (NA, NA) | 0.62 (0.53, 0.75) | NA (NA, NA) | 0.58 (0.51, 0.7) | 0.78 (0.58, 0.95) | NA (NA, NA) | 0.58 (0.52, 0.64) | NA (NA, NA) | 0.57 (0.55, 0.59) | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.51 (0.51, 0.51) | ||||||||||||||||
| HRD+ | TC3 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC3 | rate | 0.035 (0.014, 0.063) | 0.198 (0.062, 1.818) | 0.03 (0, 0.058) | 0.013 (0, 0.059) | 0 (0, 0.057) | 0 (0, 0.104) | 0 (0, 0.272) | 0.026 (0, 0.085) | 0.032 (0, 0.092) | 0 (0, 0.051) | 0 (0, 0.106) | 0 (0, 0.182) | 0 (0, 0.156) | 0 (0, 0.056) | 0 (0, 0.436) | 0 (0, 0.042) | ||||||||||||||||
| HRD+ | TC4 | count | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | 168 | ||||||||||||||||
| HRD+ | TC4 | time | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | ||||||||||||||||
| HRD+ | TC4 | n | 11 (7, 15) | 0 (0, 0) | 6 (3, 9) | 2 (0, 4) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 4 (2, 7) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC4 | post_p | 0.93 (0.77, 0.99) | 0.55 (0.55, 0.55) | 0.78 (0.58, 0.92) | 0.57 (0.51, 0.71) | 0.51 (0.51, 0.51) | 0.59 (0.52, 0.77) | NA (NA, NA) | 0.59 (0.52, 0.76) | 0.82 (0.59, 0.96) | 0.51 (0.51, 0.51) | 0.57 (0.52, 0.65) | NA (NA, NA) | 0.59 (0.52, 0.67) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.51, 0.52) | ||||||||||||||||
| HRD+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC4 | rate | 0.038 (0.017, 0.059) | 0.021 (0, 0.967) | 0.03 (0.012, 0.058) | 0.026 (0, 0.068) | 0 (0, 0.264) | 0 (0, 0.093) | 0.09 (0, 0.821) | 0 (0, 0.08) | 0.037 (0, 0.082) | 0.723 (0.145, 1.301) | 0 (0, 0.183) | 0.139 (0.113, 0.165) | 0.055 (0, 1.315) | 0.026 (0.005, 0.047) | 0.033 (0.007, 0.059) | 0.086 (0, 2.728) | ||||||||||||||||
| TP53+ | TC2 | count | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | ||||||||||||||||
| TP53+ | TC2 | time | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | ||||||||||||||||
| TP53+ | TC2 | n | 5 (3, 12) | 5 (3, 9) | 2 (0, 5) | 4 (2, 7) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 5 (2, 7) | 3 (2, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | post_p | 0.72 (0.57, 0.82) | 0.63 (0.53, 0.76) | 0.62 (0.53, 0.76) | 0.74 (0.62, 0.91) | NA (NA, NA) | 0.53 (0.52, 0.54) | NA (NA, NA) | 0.54 (0.51, 0.6) | 0.55 (0.51, 0.59) | NA (NA, NA) | 0.82 (0.59, 0.92) | 0.82 (0.56, 0.93) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | r_prob | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | rate | 0.072 (0.027, 0.093) | 0.106 (0.065, 0.128) | 0.038 (0, 0.131) | 0.04 (0, 0.098) | NA (NA, NA) | 0.114 (0, 1.064) | NA (NA, NA) | 0 (0, 0.196) | 0.1 (0, 8.222) | NA (NA, NA) | 0.037 (0, 0.059) | 0.027 (0, 0.068) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | count | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | ||||||||||||||||
| TP53+ | TC5 | time | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | 15 (14, 25) | ||||||||||||||||
| TP53+ | TC5 | n | 5 (3, 10) | 6 (3, 10) | 1 (0, 3) | 4 (2, 8) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 4 (2, 6) | 4 (2, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | post_p | 0.7 (0.53, 0.75) | 0.89 (0.74, 0.98) | 0.57 (0.53, 0.69) | 0.73 (0.6, 0.95) | NA (NA, NA) | 0.55 (0.52, 0.72) | NA (NA, NA) | 0.58 (0.55, 0.63) | 0.57 (0.53, 0.67) | NA (NA, NA) | 0.55 (0.51, 0.73) | 0.73 (0.59, 0.86) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC5 | r_prob | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | rate | 0.078 (0.043, 0.11) | 0.031 (0, 0.067) | 0.064 (0, 0.139) | 0.026 (0, 0.069) | NA (NA, NA) | 0 (0, 0.099) | NA (NA, NA) | 0 (0, 0.1) | 0.169 (0, 0.249) | NA (NA, NA) | 0.086 (0.042, 0.131) | 0.017 (0, 0.068) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | count | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | ||||||||||||||||
| TEfus+ | TC2 | time | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | ||||||||||||||||
| TEfus+ | TC2 | n | 1 (0, 3) | 3 (1, 7) | 2 (0, 5) | 6 (3, 10) | 3 (1, 5) | 2 (0, 3) | 0 (0, 0) | 1 (0, 3) | 2 (0, 4) | 1 (0, 3) | 6 (3, 11) | 4 (2, 9) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | post_p | 0.61 (0.53, 0.77) | 0.64 (0.53, 0.82) | 0.64 (0.53, 0.86) | 0.76 (0.58, 0.92) | 0.59 (0.52, 0.81) | 0.55 (0.51, 0.65) | NA (NA, NA) | 0.55 (0.51, 0.65) | 0.65 (0.54, 0.85) | 0.59 (0.52, 0.69) | 0.84 (0.68, 0.97) | 0.72 (0.54, 0.89) | 0.52 (0.5, 0.58) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | rate | 0 (0, 0.098) | 0.038 (0, 0.085) | 0.023 (0, 0.09) | 0.031 (0, 0.082) | 0.026 (0, 0.083) | 0 (0, 0.117) | 0 (0, 0) | 0 (0, 0.108) | 0.015 (0, 0.089) | 0 (0, 0.125) | 0.034 (0, 0.073) | 0.043 (0, 0.088) | 0 (0, 0.381) | 0.191 (0.167, 0.216) | 0.152 (0.03, 0.274) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| TEfus+ | TC5 | time | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | ||||||||||||||||
| TEfus+ | TC5 | n | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 8 (8, 8) | 3 (3, 3) | 2 (2, 2) | 0 (0, 0) | 3 (3, 3) | 1 (1, 1) | 0 (0, 0) | 5 (5, 5) | 6 (6, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | post_p | NA (NA, NA) | 0.61 (0.61, 0.61) | NA (NA, NA) | 0.84 (0.84, 0.84) | 0.59 (0.59, 0.59) | 0.58 (0.58, 0.58) | NA (NA, NA) | 0.58 (0.58, 0.58) | 0.59 (0.59, 0.59) | NA (NA, NA) | 0.55 (0.55, 0.55) | 0.73 (0.73, 0.73) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | rate | 9.681 (9.681, 9.681) | 0 (0, 0) | NA (NA, NA) | 0.033 (0.033, 0.033) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.113 (0.113, 0.113) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| PI3K+ | TC1 | time | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | 18 (14, 22) | ||||||||||||||||
| PI3K+ | TC1 | n | 6 (5, 7) | 5 (5, 5) | 8 (5, 12) | 4 (4, 4) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 2 (1, 2) | 0 (0, 1) | 1 (1, 1) | 0 (0, 0) | 2 (1, 3) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | post_p | 0.82 (0.69, 0.95) | 0.59 (0.59, 0.59) | 0.69 (0.55, 0.83) | 0.72 (0.63, 0.8) | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.51 (0.51, 0.51) | 0.54 (0.54, 0.54) | 0.59 (0.59, 0.59) | 0.57 (0.55, 0.6) | NA (NA, NA) | 0.59 (0.58, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | r_prob | 0.22 (0.22, 0.22) | 0.22 (0.22, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.14 (0.14, 0.14) | 0.14 (0.14, 0.14) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | rate | 0.036 (0.016, 0.056) | 0.027 (0.005, 0.048) | 0.13 (0.094, 0.165) | 0.034 (0.007, 0.06) | NA (NA, NA) | 0 (0, 0) | 0.209 (0.209, 0.209) | 0.302 (0.195, 0.41) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.034 (0.007, 0.062) | NA (NA, NA) | 0.853 (0.853, 0.853) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| PI3K+ | TC2 | time | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | ||||||||||||||||
| PI3K+ | TC2 | n | 6 (3, 8) | 6 (3, 8) | 4 (3, 5) | 2 (1, 4) | 0 (0, 1) | 2 (2, 3) | 0 (0, 1) | 0 (0, 1) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 4 (3, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | post_p | 0.73 (0.71, 0.74) | 0.78 (0.64, 0.92) | 0.54 (0.51, 0.57) | 0.62 (0.6, 0.63) | NA (NA, NA) | 0.54 (0.53, 0.55) | NA (NA, NA) | NA (NA, NA) | 0.56 (0.53, 0.59) | 0.56 (0.52, 0.6) | NA (NA, NA) | 0.64 (0.6, 0.68) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | r_prob | 0.03 (0.03, 0.03) | 0.03 (0.03, 0.03) | 0.07 (0.07, 0.07) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | rate | 0.048 (0.01, 0.086) | 0.011 (0.002, 0.02) | 0.104 (0.099, 0.109) | 0.05 (0.01, 0.091) | 1.026 (1.026, 1.026) | 0.038 (0.008, 0.069) | 0.346 (0.346, 0.346) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.041 (0.008, 0.074) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | count | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | 305 | ||||||||||||||||
| PI3K+ | TC5 | time | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | 19 (14, 28) | ||||||||||||||||
| PI3K+ | TC5 | n | 7 (4, 13) | 3 (1, 7) | 6 (3, 11) | 5 (2, 9) | 0 (0, 0) | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 0 (0, 2) | 1 (0, 3) | 0 (0, 0) | 4 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | post_p | 0.89 (0.72, 0.99) | 0.66 (0.53, 0.88) | 0.9 (0.7, 0.99) | 0.78 (0.58, 0.96) | NA (NA, NA) | 0.55 (0.51, 0.65) | 0.56 (0.52, 0.66) | 0.56 (0.51, 0.64) | 0.56 (0.52, 0.69) | 0.58 (0.52, 0.73) | NA (NA, NA) | 0.74 (0.56, 0.92) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.55 (0.55, 0.55) | ||||||||||||||||
| PI3K+ | TC5 | r_prob | 0.38 (0.38, 0.38) | 0.38 (0.38, 0.38) | 0.33 (0.33, 0.33) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | rate | 0.031 (0, 0.062) | 0.02 (0, 0.068) | 0.037 (0, 0.084) | 0.028 (0, 0.07) | 0 (0, 0) | 0 (0, 0.077) | 0 (0, 0.117) | 0 (0, 0.088) | 0 (0, 0.137) | 0 (0, 0.098) | 0 (0, 0.255) | 0.03 (0, 0.073) | 0 (0, 0.102) | 0.081 (0.081, 0.081) | 0.119 (0, 0.346) | 0 (0, 0.176) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC4 | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| all | TC4 | time | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) |
| all | TC4 | n | 12 (6, 16) | 2 (1, 4) | 1 (0, 1) | 0 (0, 3) | 1 (0, 4) | 2 (0, 3) | 0 (0, 1) | 2 (1, 4) | 2 (0, 3) | 0 (0, 0) | 2 (0, 4) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 2 (1, 2) | 2 (0, 3) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.29 (0.05, 0.43) | 0.4 (0.34, 0.46) | 0.42 (0.39, 0.45) | 0.28 (0.24, 0.38) | 0.42 (0.38, 0.45) | 0.43 (0.34, 0.45) | 0.44 (0.42, 0.45) | 0.42 (0.35, 0.49) | 0.45 (0.41, 0.47) | NA (NA, NA) | 0.49 (0.47, 0.5) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.48, 0.48) | NA (NA, NA) | 0.44 (0.42, 0.46) | 0.39 (0.39, 0.39) | 0.39 (0.39, 0.39) | NA (NA, NA) | 0.38 (0.3, 0.44) | 0.43 (0.38, 0.47) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.221 (0.161, 0.534) | 0.269 (0.097, 0.645) | 0.459 (0.266, 1.065) | 0.916 (0.626, 2.501) | 0.14 (0.103, 7.729) | 0.435 (0.289, 0.669) | 0.396 (0.058, 2.14) | 0.204 (0.054, 1.17) | 0.143 (0.04, 0.461) | NA (NA, NA) | 0.039 (0, 0.219) | 0 (0, 0) | NA (NA, NA) | 0.13 (0.026, 0.234) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 9.948 (0.365, 19.788) | 0.572 (0.572, 0.572) | 0.145 (0.029, 0.261) | NA (NA, NA) | 0.303 (0.193, 1.495) | 0.22 (0.143, 0.288) | 0.082 (0.016, 0.148) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) |
| all | TC5 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| all | TC5 | time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) |
| all | TC5 | n | 11 (11, 11) | 2 (2, 2) | 2 (2, 2) | 1 (1, 1) | 2 (2, 2) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | post_p | 0.4 (0.4, 0.4) | 0.46 (0.46, 0.46) | 0.44 (0.44, 0.44) | NA (NA, NA) | 0.49 (0.49, 0.49) | 0.47 (0.47, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | rate | 0.19 (0.19, 0.19) | 0.377 (0.377, 0.377) | 0.24 (0.24, 0.24) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 3.277 (3.277, 3.277) | NA (NA, NA) | 0.39 (0.39, 0.39) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.316 (0.316, 0.316) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| AR- & TP53- | TC2 | count | 101 | 101 | 101 | 101 | 101 | 101 | 101 | 101 | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | time | 13 (8, 22) | 13 (8, 22) | 13 (8, 22) | 13 (8, 22) | 13 (8, 22) | 13 (8, 22) | 13 (8, 22) | 13 (8, 22) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | n | 19 (14, 30) | 5 (2, 10) | 0 (0, 2) | 2 (0, 4) | 4 (2, 9) | 0 (0, 0) | 2 (0, 5) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | post_p | 0.1 (0.01, 0.37) | 0.37 (0.12, 0.48) | 0.45 (0.37, 0.5) | 0.46 (0.36, 0.5) | 0.35 (0.1, 0.46) | NA (NA, NA) | 0.44 (0.38, 0.48) | 0.45 (0.36, 0.49) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | rate | 0.183 (0.125, 0.263) | 0.198 (0.111, 0.408) | 0.111 (0, 0.496) | 0.112 (0.042, 0.359) | 0.179 (0.113, 0.429) | 0 (0, 0.351) | 0.125 (0.029, 0.351) | 0.066 (0, 0.511) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 18 (13, 26) | 5 (3, 7) | 1 (0, 2) | 2 (0, 5) | 3 (1, 7) | 0 (0, 0) | 1 (0, 3) | 0 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.17 (0.02, 0.34) | 0.35 (0.15, 0.48) | 0.43 (0.38, 0.46) | 0.38 (0.31, 0.44) | 0.44 (0.35, 0.49) | NA (NA, NA) | 0.43 (0.39, 0.48) | 0.45 (0.39, 0.48) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.163 (0.127, 0.25) | 0.175 (0.12, 0.365) | 0.43 (0.153, 2.226) | 0.2 (0.071, 0.597) | 0.111 (0.059, 0.426) | NA (NA, NA) | 0.144 (0.05, 0.395) | 0.072 (0, 0.263) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | count | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | time | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | 11 (8, 16) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | n | 16 (12, 27) | 4 (3, 7) | 1 (0, 2) | 2 (0, 4) | 3 (1, 7) | 0 (0, 0) | 2 (0, 4) | 1 (0, 1) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | post_p | 0.08 (0, 0.28) | 0.31 (0.12, 0.43) | 0.42 (0.36, 0.46) | 0.36 (0.26, 0.47) | 0.45 (0.4, 0.49) | NA (NA, NA) | 0.44 (0.36, 0.49) | 0.47 (0.43, 0.49) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | rate | 0.205 (0.164, 0.318) | 0.234 (0.149, 0.494) | 0.28 (0.115, 2.45) | 0.293 (0.132, 0.991) | 0.097 (0.053, 0.33) | 0 (0, 0) | 0.116 (0, 0.396) | 0.043 (0, 0.452) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 22 | 22 | 22 | 22 | 22 | 22 | 22 | 22 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 12 (8, 18) | 12 (8, 18) | 12 (8, 18) | 12 (8, 18) | 12 (8, 18) | 12 (8, 18) | 12 (8, 18) | 12 (8, 18) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 16 (13, 23) | 4 (1, 7) | 1 (0, 2) | 2 (0, 4) | 5 (2, 7) | 0 (0, 0) | 2 (0, 5) | 0 (0, 4) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.16 (0.02, 0.33) | 0.44 (0.38, 0.48) | 0.43 (0.28, 0.47) | 0.45 (0.34, 0.49) | 0.34 (0.14, 0.48) | NA (NA, NA) | 0.36 (0.21, 0.41) | 0.45 (0.43, 0.49) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.183 (0.144, 0.218) | 0.142 (0.09, 0.291) | 0.179 (0.137, 0.585) | 0.106 (0.054, 0.341) | 0.202 (0.114, 0.379) | 1.194 (1.194, 1.194) | 0.224 (0.127, 0.77) | 0.099 (0.029, 0.158) | ||||||||||||||||||||||||
| HRD+ | TC1 | count | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | ||||||||||||||||
| HRD+ | TC1 | time | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | ||||||||||||||||
| HRD+ | TC1 | n | 12 (9, 13) | 0 (0, 1) | 6 (3, 8) | 2 (1, 6) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 2 (0, 4) | 4 (2, 8) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | post_p | 0.4 (0.19, 0.47) | NA (NA, NA) | 0.36 (0.21, 0.46) | 0.43 (0.29, 0.49) | NA (NA, NA) | 0.46 (0.36, 0.49) | NA (NA, NA) | 0.38 (0.27, 0.44) | 0.33 (0.09, 0.43) | NA (NA, NA) | 0.44 (0.43, 0.44) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | rate | 0.11 (0.084, 0.137) | 0 (0, 0) | 0.12 (0.061, 0.223) | 0.091 (0.073, 0.228) | NA (NA, NA) | 0.171 (0.046, 0.405) | 0.306 (0.306, 0.306) | 0.204 (0.133, 0.609) | 0.241 (0.154, 0.315) | NA (NA, NA) | 0.346 (0.333, 0.465) | NA (NA, NA) | 0 (0, 0) | 0.083 (0.083, 0.083) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC2 | count | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | ||||||||||||||||
| HRD+ | TC2 | time | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | ||||||||||||||||
| HRD+ | TC2 | n | 12 (9, 16) | 0 (0, 0) | 5 (3, 9) | 3 (0, 5) | 0 (0, 0) | 1 (0, 4) | 0 (0, 0) | 1 (0, 4) | 4 (2, 8) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | post_p | 0.1 (0.02, 0.3) | NA (NA, NA) | 0.4 (0.23, 0.49) | 0.44 (0.31, 0.49) | NA (NA, NA) | 0.42 (0.3, 0.48) | NA (NA, NA) | 0.45 (0.37, 0.49) | 0.32 (0.17, 0.46) | NA (NA, NA) | 0.45 (0.42, 0.48) | 0.46 (0.46, 0.46) | 0.41 (0.41, 0.41) | 0.49 (0.49, 0.49) | NA (NA, NA) | 0.44 (0.44, 0.44) | ||||||||||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | rate | 0.188 (0.139, 0.278) | 0.714 (0.121, 2.956) | 0.084 (0.055, 0.227) | 0.092 (0.042, 0.722) | 0.188 (0.082, 0.294) | 0.25 (0.122, 1.197) | 0 (0, 0) | 0.123 (0.046, 0.418) | 0.225 (0.125, 0.423) | 0.305 (0.026, 3.399) | 0.107 (0.01, 1.346) | 0.043 (0.009, 0.077) | 0.747 (0.271, 9.339) | 0.055 (0, 1.548) | 0.093 (0.066, 0.12) | 0.054 (0.011, 0.097) | ||||||||||||||||
| HRD+ | TC5 | count | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | ||||||||||||||||
| HRD+ | TC5 | time | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | 30 (24, 34) | ||||||||||||||||
| HRD+ | TC5 | n | 12 (8, 17) | 0 (0, 0) | 6 (3, 10) | 1 (0, 4) | 0 (0, 0) | 0 (0, 3) | 0 (0, 0) | 1 (0, 3) | 4 (2, 7) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | post_p | 0.09 (0.01, 0.26) | NA (NA, NA) | 0.16 (0.04, 0.3) | 0.44 (0.35, 0.49) | NA (NA, NA) | 0.47 (0.41, 0.5) | NA (NA, NA) | 0.44 (0.39, 0.47) | 0.37 (0.14, 0.47) | NA (NA, NA) | 0.45 (0.41, 0.48) | NA (NA, NA) | 0.46 (0.45, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC5 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | rate | 0.181 (0.135, 0.282) | 0.096 (0.096, 0.096) | 0.212 (0.128, 0.371) | 0.07 (0.039, 0.286) | 1.183 (1.183, 1.183) | 0.116 (0.046, 0.277) | 0.063 (0, 0.393) | 0.1 (0.024, 0.567) | 0.22 (0.123, 0.518) | 0.068 (0.068, 0.068) | 0.371 (0.102, 1.589) | NA (NA, NA) | 0.199 (0.072, 0.547) | 0.422 (0.422, 0.422) | 0.244 (0.154, 1.198) | 0.105 (0.105, 0.105) | ||||||||||||||||
| TP53+ | TC1 | count | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | 105 | ||||||||||||||||
| TP53+ | TC1 | time | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | ||||||||||||||||
| TP53+ | TC1 | n | 7 (4, 12) | 7 (3, 12) | 2 (0, 5) | 6 (2, 10) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 1 (0, 3) | 0 (0, 1) | 0 (0, 0) | 6 (3, 12) | 5 (2, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | post_p | 0.37 (0.14, 0.48) | 0.36 (0.14, 0.47) | 0.39 (0.26, 0.48) | 0.31 (0.1, 0.47) | 0.44 (0.44, 0.44) | 0.44 (0.37, 0.48) | 0.44 (0.44, 0.44) | 0.43 (0.33, 0.48) | 0.45 (0.4, 0.48) | NA (NA, NA) | 0.31 (0.16, 0.47) | 0.36 (0.19, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC1 | r_prob | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | rate | 0.143 (0.107, 0.252) | 0.18 (0.126, 0.318) | 0.193 (0.089, 0.576) | 0.177 (0.105, 0.337) | 0.115 (0.023, 0.262) | 0.189 (0.051, 0.707) | 0.135 (0.094, 6.182) | 0.172 (0.083, 0.78) | 0.335 (0.026, 1.93) | 0.122 (0.024, 1.302) | 0.155 (0.103, 0.272) | 0.162 (0.114, 0.305) | 0.07 (0, 0.32) | 0.11 (0.11, 0.11) | 0.111 (0.022, 0.187) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| TP53+ | TC2 | time | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | ||||||||||||||||
| TP53+ | TC2 | n | 9 (9, 9) | 5 (5, 5) | 2 (2, 2) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 4 (4, 4) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | post_p | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.45 (0.45, 0.45) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.44 (0.44, 0.44) | NA (NA, NA) | 0.49 (0.49, 0.49) | 0.36 (0.36, 0.36) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | r_prob | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | rate | 0.182 (0.182, 0.182) | 0.283 (0.283, 0.283) | 0.295 (0.295, 0.295) | 0.124 (0.124, 0.124) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.387 (0.387, 0.387) | NA (NA, NA) | 0.059 (0.059, 0.059) | 0.199 (0.199, 0.199) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | count | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | ||||||||||||||||
| TP53+ | TC3 | time | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | 20 (15, 31) | ||||||||||||||||
| TP53+ | TC3 | n | 8 (4, 13) | 7 (4, 11) | 2 (1, 5) | 5 (3, 9) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 6 (3, 11) | 4 (2, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC3 | post_p | 0.36 (0.16, 0.48) | 0.32 (0.15, 0.47) | 0.39 (0.26, 0.47) | 0.31 (0.1, 0.46) | 0.44 (0.44, 0.44) | 0.47 (0.41, 0.49) | NA (NA, NA) | 0.45 (0.37, 0.5) | 0.44 (0.38, 0.48) | NA (NA, NA) | 0.27 (0.08, 0.45) | 0.35 (0.18, 0.48) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC3 | rate | 0.148 (0.103, 0.244) | 0.175 (0.124, 0.38) | 0.256 (0.12, 0.814) | 0.181 (0.103, 0.307) | 0 (0, 0.524) | 0.087 (0, 0.278) | 0 (0, 0) | 0.102 (0, 0.453) | 0.485 (0.06, 2.401) | 0.926 (0.185, 1.667) | 0.194 (0.113, 0.353) | 0.167 (0.117, 0.454) | 0 (0, 0.035) | 0 (0, 0.163) | NA (NA, NA) | 0.035 (0, 0.125) | ||||||||||||||||
| TP53+ | TC4 | count | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | ||||||||||||||||
| TP53+ | TC4 | time | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | 20 (13, 30) | ||||||||||||||||
| TP53+ | TC4 | n | 7 (4, 11) | 6 (3, 9) | 2 (0, 4) | 4 (2, 7) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 5 (2, 10) | 4 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC4 | post_p | 0.38 (0.19, 0.48) | 0.28 (0.09, 0.45) | 0.39 (0.21, 0.47) | 0.26 (0.08, 0.43) | NA (NA, NA) | 0.47 (0.4, 0.49) | 0.42 (0.42, 0.42) | 0.46 (0.38, 0.49) | 0.46 (0.39, 0.48) | NA (NA, NA) | 0.26 (0.07, 0.43) | 0.27 (0.11, 0.45) | 0.47 (0.46, 0.49) | NA (NA, NA) | NA (NA, NA) | 0.45 (0.45, 0.45) | ||||||||||||||||
| TP53+ | TC4 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC4 | rate | 0.148 (0.104, 0.254) | 0.236 (0.152, 0.392) | 0.314 (0.135, 1.487) | 0.236 (0.142, 0.518) | 0.605 (0.158, 1.052) | 0.081 (0, 0.422) | 0 (0, 0.282) | 0.088 (0, 0.546) | 0.278 (0.117, 1.298) | 0.213 (0.065, 0.503) | 0.237 (0.134, 0.505) | 0.244 (0.119, 0.49) | 0 (0, 0.259) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.207) | ||||||||||||||||
| TEfus+ | TC1 | count | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | ||||||||||||||||
| TEfus+ | TC1 | time | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | ||||||||||||||||
| TEfus+ | TC1 | n | 1 (0, 3) | 4 (1, 8) | 2 (1, 5) | 7 (2, 15) | 2 (0, 8) | 2 (0, 4) | 0 (0, 1) | 1 (0, 3) | 1 (0, 3) | 1 (0, 4) | 8 (3, 10) | 6 (3, 11) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | post_p | 0.44 (0.4, 0.48) | 0.4 (0.18, 0.49) | 0.38 (0.19, 0.47) | 0.27 (0.12, 0.47) | 0.36 (0.2, 0.46) | 0.41 (0.37, 0.47) | NA (NA, NA) | 0.41 (0.33, 0.47) | 0.42 (0.29, 0.49) | 0.41 (0.32, 0.49) | 0.28 (0.15, 0.39) | 0.3 (0.21, 0.43) | 0.44 (0.41, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | rate | 0.131 (0.068, 0.594) | 0.085 (0.077, 0.215) | 0.235 (0.172, 0.413) | 0.146 (0.099, 0.309) | 0.133 (0.077, 0.362) | 0.105 (0.072, 0.315) | 0.467 (0.201, 8.241) | 0.16 (0.077, 1.286) | 0.221 (0.112, 0.564) | 0.184 (0.118, 0.538) | 0.167 (0.115, 0.369) | 0.157 (0.109, 0.274) | 0.112 (0, 0.243) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | count | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | ||||||||||||||||
| TEfus+ | TC3 | time | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | 22 (16, 30) | ||||||||||||||||
| TEfus+ | TC3 | n | 0 (0, 2) | 4 (2, 8) | 2 (1, 4) | 6 (3, 10) | 2 (0, 6) | 1 (0, 2) | 0 (0, 0) | 0 (0, 2) | 2 (1, 5) | 2 (0, 3) | 7 (4, 9) | 5 (2, 8) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC3 | post_p | 0.39 (0.21, 0.46) | 0.28 (0.16, 0.42) | 0.39 (0.29, 0.47) | 0.29 (0.14, 0.43) | 0.44 (0.33, 0.49) | 0.44 (0.38, 0.47) | NA (NA, NA) | 0.47 (0.39, 0.49) | 0.38 (0.16, 0.47) | 0.42 (0.28, 0.48) | 0.24 (0.08, 0.42) | 0.27 (0.08, 0.44) | 0.46 (0.44, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC3 | rate | 0.309 (0.11, 1.156) | 0.181 (0.103, 0.604) | 0.227 (0.114, 0.629) | 0.179 (0.106, 0.279) | 0.101 (0.044, 0.338) | 0.107 (0.005, 0.443) | NA (NA, NA) | 0.099 (0.01, 0.614) | 0.214 (0.122, 0.843) | 0.239 (0.054, 0.428) | 0.216 (0.133, 0.345) | 0.199 (0.123, 0.572) | 0.196 (0.129, 0.547) | 0 (0, 0) | NA (NA, NA) | 0.054 (0.011, 0.097) | ||||||||||||||||
| TEfus+ | TC4 | count | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | ||||||||||||||||
| TEfus+ | TC4 | time | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | 22 (16, 29) | ||||||||||||||||
| TEfus+ | TC4 | n | 1 (0, 4) | 4 (2, 8) | 2 (0, 4) | 5 (2, 7) | 3 (0, 6) | 1 (0, 3) | 0 (0, 0) | 0 (0, 1) | 2 (1, 4) | 1 (0, 3) | 6 (3, 11) | 4 (2, 7) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC4 | post_p | 0.4 (0.31, 0.46) | 0.25 (0.1, 0.43) | 0.42 (0.24, 0.47) | 0.17 (0.05, 0.42) | 0.45 (0.32, 0.49) | 0.45 (0.39, 0.5) | 0.48 (0.48, 0.48) | 0.45 (0.4, 0.49) | 0.37 (0.18, 0.48) | 0.39 (0.24, 0.43) | 0.2 (0.06, 0.41) | 0.24 (0.09, 0.45) | 0.46 (0.41, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC4 | rate | 0.282 (0.144, 1.109) | 0.229 (0.115, 0.573) | 0.242 (0.131, 0.848) | 0.289 (0.143, 0.528) | 0.093 (0.052, 0.241) | 0.086 (0.03, 0.219) | 0.176 (0.035, 0.317) | 0.109 (0, 0.207) | 0.244 (0.15, 0.588) | 0.343 (0.164, 1.081) | 0.247 (0.151, 0.47) | 0.214 (0.123, 0.408) | 0 (0, 0.19) | 0.05 (0.01, 0.09) | 0 (0, 0) | 0.102 (0.02, 0.184) | ||||||||||||||||
| PI3K+ | TC1 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||||||||||
| PI3K+ | TC1 | time | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | 18 (12, 34) | ||||||||||||||||
| PI3K+ | TC1 | n | 4 (2, 8) | 3 (2, 5) | 6 (3, 12) | 5 (4, 9) | 0 (0, 0) | 1 (0, 4) | 0 (0, 1) | 1 (0, 4) | 0 (0, 2) | 1 (0, 2) | 0 (0, 0) | 6 (4, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | post_p | 0.42 (0.28, 0.5) | 0.42 (0.35, 0.48) | 0.39 (0.22, 0.43) | 0.35 (0.24, 0.43) | NA (NA, NA) | 0.43 (0.39, 0.47) | 0.44 (0.39, 0.44) | 0.36 (0.21, 0.46) | 0.4 (0.39, 0.42) | 0.49 (0.41, 0.49) | 0.45 (0.45, 0.45) | 0.38 (0.29, 0.45) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | r_prob | 0.22 (0.22, 0.22) | 0.22 (0.22, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.14 (0.14, 0.14) | 0.14 (0.14, 0.14) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | rate | 0.117 (0.1, 0.162) | 0.112 (0.072, 0.221) | 0.197 (0.14, 0.366) | 0.142 (0.119, 0.248) | NA (NA, NA) | 0.086 (0.022, 0.29) | 0.325 (0.059, 0.813) | 0.189 (0.084, 0.605) | 1.028 (0.276, 1.163) | 0.074 (0, 0.268) | 0.193 (0.193, 0.193) | 0.157 (0.126, 0.18) | 0.394 (0.394, 0.394) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||
| PI3K+ | TC2 | time | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | 15 (13, 25) | ||||||||||||||||
| PI3K+ | TC2 | n | 8 (4, 8) | 1 (0, 6) | 5 (4, 5) | 6 (6, 7) | 0 (0, 0) | 2 (0, 2) | 0 (0, 1) | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 1) | 4 (2, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | post_p | 0.36 (0.35, 0.38) | 0.48 (0.47, 0.48) | 0.28 (0.27, 0.32) | 0.47 (0.36, 0.48) | NA (NA, NA) | 0.41 (0.4, 0.42) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.46 (0.46, 0.46) | NA (NA, NA) | 0.48 (0.33, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | r_prob | 0.03 (0.03, 0.03) | 0.03 (0.03, 0.03) | 0.07 (0.07, 0.07) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | rate | 0.142 (0.128, 0.15) | 0.193 (0.073, 0.313) | 0.204 (0.199, 0.541) | 0.108 (0.106, 0.123) | NA (NA, NA) | 0.516 (0.226, 0.806) | 0.193 (0.193, 0.193) | 0.067 (0.013, 0.12) | 0 (0, 0) | 0.111 (0.111, 0.111) | 0.203 (0.203, 0.203) | 0.097 (0.084, 0.11) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC3 | count | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | 87 | ||||||||||||||||
| PI3K+ | TC3 | time | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | 20 (14, 30) | ||||||||||||||||
| PI3K+ | TC3 | n | 8 (5, 13) | 4 (1, 7) | 7 (3, 11) | 5 (3, 9) | 0 (0, 0) | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 1 (0, 3) | 0 (0, 0) | 4 (2, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | post_p | 0.26 (0.07, 0.44) | 0.34 (0.11, 0.46) | 0.31 (0.12, 0.47) | 0.32 (0.13, 0.46) | NA (NA, NA) | 0.45 (0.38, 0.49) | 0.46 (0.4, 0.49) | 0.45 (0.41, 0.49) | 0.42 (0.35, 0.48) | 0.42 (0.32, 0.49) | NA (NA, NA) | 0.32 (0.17, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC3 | rate | 0.175 (0.118, 0.276) | 0.183 (0.098, 0.481) | 0.192 (0.14, 0.388) | 0.165 (0.098, 0.301) | 1.333 (0.419, 2.246) | 0.087 (0, 0.33) | 0.098 (0, 0.531) | 0.106 (0, 0.475) | 0.287 (0.129, 1.19) | 0.25 (0.055, 1.205) | NA (NA, NA) | 0.178 (0.114, 0.544) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0.26) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC4 | count | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | 154 | ||||||||||||||||
| PI3K+ | TC4 | time | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | 19 (13, 27) | ||||||||||||||||
| PI3K+ | TC4 | n | 7 (4, 11) | 3 (1, 7) | 6 (3, 10) | 5 (2, 7) | 0 (0, 0) | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 1 (0, 3) | 0 (0, 0) | 4 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC4 | post_p | 0.18 (0.03, 0.35) | 0.3 (0.12, 0.43) | 0.27 (0.12, 0.43) | 0.25 (0.09, 0.43) | NA (NA, NA) | 0.46 (0.37, 0.49) | 0.46 (0.41, 0.5) | 0.45 (0.4, 0.5) | 0.44 (0.36, 0.49) | 0.41 (0.31, 0.47) | NA (NA, NA) | 0.29 (0.08, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.47 (0.47, 0.47) | ||||||||||||||||
| PI3K+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC4 | rate | 0.238 (0.148, 0.416) | 0.228 (0.11, 0.598) | 0.23 (0.153, 0.386) | 0.239 (0.138, 0.481) | 0 (0, 0) | 0.077 (0, 0.247) | 0.102 (0, 0.392) | 0.105 (0, 0.54) | 0.362 (0.103, 1.483) | 0.362 (0.11, 1.083) | 4.955 (4.955, 4.955) | 0.245 (0.106, 0.461) | 0 (0, 0.114) | 0.05 (0.01, 0.09) | 0 (0, 0.103) | 0 (0, 0.207) |