Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.086, shape = 1.05 scale = 0.132, shape = 1.05 scale = 0.133, shape = 1.05 scale = 0.178, shape = 1.05 scale = 0.128, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 11.4, median = 8.2 mean = 7.4, median = 5.3 mean = 7.4, median = 5.3 mean = 5.5, median = 4 mean = 7.7, median = 5.5
all effect af = 1, hr = 1 af = 1.29, hr = 0.76 af = 0.84, hr = 1.19 af = 0.84, hr = 1.21 af = 0.63, hr = 1.63 af = 0.88, hr = 1.15
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.159, shape = 1.05 scale = 0.132, shape = 1.05 scale = 0.18, shape = 1.05 scale = 0.149, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 19.8, median = 14.2 mean = 6.2, median = 4.4 mean = 7.4, median = 5.3 mean = 5.5, median = 3.9 mean = 6.6, median = 4.7
AR- & TP53- effect af = 1, hr = 1 af = 2.25, hr = 0.43 af = 0.7, hr = 1.45 af = 0.84, hr = 1.2 af = 0.62, hr = 1.65 af = 0.75, hr = 1.35
HRD+ param scale = 0.112, shape = 1.05 scale = 0.086, shape = 1.05 scale = 0.135, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.153, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 11.4, median = 8.2 mean = 7.2, median = 5.2 mean = 25, median = 18 mean = 25, median = 18 mean = 6.4, median = 4.6
HRD+ effect af = 1, hr = 1 af = 1.3, hr = 0.76 af = 0.82, hr = 1.23 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.73, hr = 1.39
TP53+ param scale = 0.112, shape = 1.05 scale = 0.133, shape = 1.05 scale = 0.095, shape = 1.05 scale = 0.14, shape = 1.05 scale = 0.184, shape = 1.05 scale = 0.09, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 7.4, median = 5.3 mean = 10.4, median = 7.5 mean = 7, median = 5 mean = 5.3, median = 3.8 mean = 10.9, median = 7.8
TP53+ effect af = 1, hr = 1 af = 0.84, hr = 1.2 af = 1.18, hr = 0.84 af = 0.79, hr = 1.27 af = 0.61, hr = 1.69 af = 1.24, hr = 0.8
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.116, shape = 1.05 scale = 0.049, shape = 1.05 scale = 0.135, shape = 1.05 scale = 0.183, shape = 1.05 scale = 0.107, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.4, median = 6.1 mean = 19.9, median = 14.3 mean = 7.3, median = 5.2 mean = 5.4, median = 3.9 mean = 9.1, median = 6.6
TEfus+ effect af = 1, hr = 1 af = 0.96, hr = 1.04 af = 2.27, hr = 0.42 af = 0.83, hr = 1.22 af = 0.61, hr = 1.68 af = 1.04, hr = 0.96
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.107, shape = 1.05 scale = 0.117, shape = 1.05 scale = 0.145, shape = 1.05 scale = 0.198, shape = 1.05 scale = 0.038, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 9.2, median = 6.6 mean = 8.4, median = 6 mean = 6.8, median = 4.9 mean = 5, median = 3.6 mean = 26.1, median = 18.8
PI3K+ effect af = 1, hr = 1 af = 1.04, hr = 0.96 af = 0.96, hr = 1.05 af = 0.77, hr = 1.31 af = 0.56, hr = 1.83 af = 2.97, hr = 0.32



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
—– effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
—-+ param scale = 0.112, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 19.4, median = 14 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
—-+ effect af = 1, hr = 1 af = 2.21, hr = 0.43 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
—+- param scale = 0.112, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 17, median = 12.2 mean = 23.4, median = 16.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
—+- effect af = 1, hr = 1 af = 1.94, hr = 0.5 af = 2.67, hr = 0.36 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
—++ param scale = 0.112, shape = 1.05 scale = 0.064, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 15.4, median = 11.1 mean = 19.4, median = 14 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
—++ effect af = 1, hr = 1 af = 1.75, hr = 0.56 af = 2.21, hr = 0.43 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
–+-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
–++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
–++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
–+++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 19.4, median = 14 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
–+++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.21, hr = 0.43 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
-+— param scale = 0.112, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 17, median = 12.2 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-+— effect af = 1, hr = 1 af = 1.94, hr = 0.5 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-+–+ param scale = 0.112, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 17, median = 12.2 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-+–+ effect af = 1, hr = 1 af = 1.94, hr = 0.5 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
-+-+- param scale = 0.112, shape = 1.05 scale = 0.071, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 13.8, median = 9.9 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-+-+- effect af = 1, hr = 1 af = 1.56, hr = 0.62 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-+-++ param scale = 0.112, shape = 1.05 scale = 0.071, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 13.8, median = 9.9 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-+-++ effect af = 1, hr = 1 af = 1.56, hr = 0.62 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
-++– param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-++– effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-++-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-++-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
-+++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-+++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-++++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-++++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+—+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
+–+- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
+–+- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
+–++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+–++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
+-+– param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
+-+– effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+-+-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
+-++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
+-++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
+-+++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+-+++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
++— param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
++— effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
++–+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
++–+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
++-+- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
++-+- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
++-++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
++-++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
+++– param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
+++– effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
+++-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
+++-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
++++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.064, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 15.4, median = 11.1 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
++++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.75, hr = 0.56 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
+++++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.064, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 15.4, median = 11.1 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
+++++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.75, hr = 0.56 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 10 4 1 0 0
AR- & TP53- 186 0 3 0 1
HRD+ 3 0 184 168 0
TP53+ 0 21 0 0 19
TEfus+ 0 80 0 0 1
PI3K+ 2 2 0 0 305
TC1 TC2 TC3 TC4 TC5
all 0.020 0.008 0.002 0.000 0.000
AR- & TP53- 0.372 0.000 0.006 0.000 0.002
HRD+ 0.006 0.000 0.368 0.336 0.000
TP53+ 0.000 0.042 0.000 0.000 0.038
TEfus+ 0.000 0.160 0.000 0.000 0.002
PI3K+ 0.004 0.004 0.000 0.000 0.610
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 8 1
AR- & TP53- 0 101 31 38 22
HRD+ 12 47 0 0 78
TP53+ 105 1 79 165 0
TEfus+ 23 0 36 67 0
PI3K+ 9 3 87 154 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.016 0.002
AR- & TP53- 0.000 0.202 0.062 0.076 0.044
HRD+ 0.024 0.094 0.000 0.000 0.156
TP53+ 0.210 0.002 0.158 0.330 0.000
TEfus+ 0.046 0.000 0.072 0.134 0.000
PI3K+ 0.018 0.006 0.174 0.308 0.000
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 1 3 17 16 9
HRD+ 0 0 0 0 0
TP53+ 0 0 0 1 0
TEfus+ 0 0 0 0 0
PI3K+ 0 1 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.000 0.000
AR- & TP53- 0.002 0.006 0.034 0.032 0.018
HRD+ 0.000 0.000 0.000 0.000 0.000
TP53+ 0.000 0.000 0.000 0.002 0.000
TEfus+ 0.000 0.000 0.000 0.000 0.000
PI3K+ 0.000 0.002 0.000 0.000 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.084 0.024 0.044 0.008 0.000 0.008
err_type 0.126 0.030 0.052 0.008 0.000 0.040
pow_sign 0.916 0.372 0.160 0.368 0.336 0.610
pow_type 0.924 0.396 0.204 0.376 0.336 0.618

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 10 4 1 0 0
all futility 0 0 0 0 8 1
all max_n 0 0 0 0 0 0
all n 381 (359, 402) 158 (97, 200) 172 (113, 206) 173 (129, 211) 158 (117, 196) 160 (128, 198)
all n_unique 350 (330, 368) 142 (85, 179) 154 (100, 187) 156 (116, 191) 144 (106, 180) 145 (114, 179)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 6 (5, 8) 6 (4, 7) 6 (6, 6) 6 (6, 7) 4 (4, 4)
all post_p NA (NA, NA) 0.94 (0.49, 1) 0.15 (0.01, 0.59) 0.02 (0, 0.26) 0 (0, 0.01) 0.22 (0.02, 0.75)
all rate 0.092 (0.085, 0.101) 0.076 (0.065, 0.093) 0.105 (0.091, 0.119) 0.116 (0.103, 0.13) 0.14 (0.122, 0.158) 0.102 (0.087, 0.117)
AR- & TP53- graduation 0 186 0 3 0 1
AR- & TP53- futility 0 0 101 31 38 22
AR- & TP53- max_n 0 1 3 17 16 9
AR- & TP53- n 214 (195, 234) 88 (26, 115) 96 (30, 120) 98 (77, 126) 94 (69, 117) 94 (74, 117)
AR- & TP53- n_unique 198 (180, 215) 80 (24, 105) 88 (28, 111) 90 (70, 113) 86 (61, 109) 85 (67, 108)
AR- & TP53- time_trial 36 (36, 36) 36 (10, 36) 36 (13, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
AR- & TP53- time_stop NA (NA, NA) 12 (9, 24) 13 (8, 22) 12 (9, 17) 11 (8, 16) 12 (8, 18)
AR- & TP53- post_p NA (NA, NA) 1 (0.98, 1) 0 (0, 0.04) 0.05 (0, 0.31) 0 (0, 0.06) 0.01 (0, 0.16)
AR- & TP53- rate 0.084 (0.075, 0.095) 0.048 (0.038, 0.057) 0.139 (0.117, 0.17) 0.112 (0.095, 0.133) 0.138 (0.114, 0.168) 0.124 (0.102, 0.151)
HRD+ graduation 0 3 0 184 168 0
HRD+ futility 0 12 47 0 0 78
HRD+ max_n 0 0 0 0 0 0
HRD+ n 64 (55, 76) 26 (13, 40) 28 (16, 40) 27 (21, 38) 26 (18, 37) 29 (22, 40)
HRD+ n_unique 59 (50, 69) 23 (11, 35) 25 (14, 36) 24 (19, 34) 24 (16, 33) 26 (19, 36)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (25, 36) 36 (27, 36) 36 (32, 36)
HRD+ time_stop NA (NA, NA) 29 (24, 35) 30 (24, 35) 29 (21, 35) 30 (23, 35) 30 (24, 34)
HRD+ post_p NA (NA, NA) 0.65 (0.25, 0.91) 0.21 (0.02, 0.65) 1 (0.94, 1) 1 (0.93, 1) 0.06 (0, 0.42)
HRD+ rate 0.097 (0.08, 0.116) 0.081 (0.059, 0.113) 0.113 (0.083, 0.161) 0.038 (0.027, 0.053) 0.038 (0.027, 0.054) 0.137 (0.097, 0.182)
TP53+ graduation 0 0 21 0 0 19
TP53+ futility 0 105 1 79 165 0
TP53+ max_n 0 0 0 0 1 0
TP53+ n 133 (118, 148) 62 (31, 80) 63 (46, 81) 61 (36, 80) 52 (26, 74) 52 (37, 71)
TP53+ n_unique 122 (108, 135) 55 (28, 70) 55 (41, 71) 54 (32, 70) 46 (24, 66) 46 (32, 63)
TP53+ time_trial 36 (36, 36) 36 (21, 36) 36 (36, 36) 36 (25, 36) 36 (16, 36) 36 (36, 36)
TP53+ time_stop NA (NA, NA) 21 (13, 32) 19 (15, 24) 20 (15, 31) 20 (13, 30) 15 (14, 25)
TP53+ post_p NA (NA, NA) 0.09 (0.01, 0.43) 0.95 (0.65, 1) 0.09 (0.01, 0.44) 0.01 (0, 0.15) 0.97 (0.71, 1)
TP53+ rate 0.104 (0.089, 0.119) 0.135 (0.114, 0.164) 0.077 (0.061, 0.096) 0.134 (0.11, 0.168) 0.165 (0.133, 0.208) 0.072 (0.057, 0.093)
TEfus+ graduation 0 0 80 0 0 1
TEfus+ futility 0 23 0 36 67 0
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 127 (112, 141) 56 (34, 75) 58 (30, 75) 59 (39, 77) 50 (29, 72) 52 (38, 71)
TEfus+ n_unique 116 (103, 129) 49 (31, 66) 50 (27, 67) 52 (33, 69) 44 (26, 64) 47 (34, 63)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (20, 36) 36 (36, 36) 36 (25, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 24 (16, 34) 19 (14, 28) 22 (16, 30) 22 (16, 29) 15 (15, 15)
TEfus+ post_p NA (NA, NA) 0.07 (0, 0.34) 1 (0.92, 1) 0.05 (0, 0.28) 0.01 (0, 0.13) 0.54 (0.13, 0.91)
TEfus+ rate 0.08 (0.071, 0.093) 0.112 (0.094, 0.138) 0.048 (0.038, 0.061) 0.115 (0.094, 0.148) 0.139 (0.108, 0.184) 0.082 (0.064, 0.103)
PI3K+ graduation 0 2 2 0 0 305
PI3K+ futility 0 9 3 87 154 0
PI3K+ max_n 0 0 1 0 0 0
PI3K+ n 130 (115, 144) 58 (35, 80) 62 (42, 83) 62 (30, 86) 51 (25, 76) 40 (25, 71)
PI3K+ n_unique 119 (106, 133) 50 (29, 71) 55 (37, 74) 56 (27, 77) 46 (23, 68) 36 (22, 64)
PI3K+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (21, 36) 36 (17, 36) 25 (15, 36)
PI3K+ time_stop NA (NA, NA) 18 (13, 34) 15 (13, 25) 20 (14, 30) 19 (13, 27) 19 (14, 28)
PI3K+ post_p NA (NA, NA) 0.48 (0.09, 0.89) 0.61 (0.16, 0.94) 0.05 (0, 0.33) 0 (0, 0.06) 1 (1, 1)
PI3K+ rate 0.098 (0.085, 0.113) 0.099 (0.079, 0.127) 0.093 (0.074, 0.118) 0.134 (0.109, 0.164) 0.174 (0.138, 0.225) 0.036 (0.027, 0.047)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 196 4 4 0 1
—– futility 0 0 101 31 45 23
—– max_n 0 1 3 17 16 9
—– n 118 (105, 132) 44 (14, 59) 49 (18, 64) 53 (39, 68) 52 (36, 66) 53 (41, 68)
—– n_unique 109 (96, 123) 41 (14, 56) 46 (17, 61) 50 (37, 64) 49 (32, 63) 50 (38, 64)
—– post_p NA (NA, NA) 1 (0.98, 1) 0 (0, 0.04) 0 (0, 0.08) 0 (0, 0) 0 (0, 0.01)
—– rate 0.086 (0.072, 0.101) 0.04 (0.03, 0.053) 0.185 (0.152, 0.226) 0.158 (0.13, 0.195) 0.221 (0.182, 0.263) 0.184 (0.154, 0.223)
—-+ graduation 0 194 6 4 0 302
—-+ futility 0 9 101 109 185 20
—-+ max_n 0 1 3 17 16 7
—-+ n 30 (23, 38) 12 (3, 22) 14 (5, 22) 14 (6, 23) 12 (5, 21) 9 (4, 18)
—-+ n_unique 28 (21, 35) 11 (2, 19) 13 (4, 21) 13 (5, 21) 11 (4, 19) 8 (4, 16)
—-+ post_p NA (NA, NA) 0.93 (0.6, 1) 0.09 (0.01, 0.33) 0.15 (0.03, 0.42) 0.05 (0, 0.23) 0.98 (0.79, 1)
—-+ rate 0.093 (0.068, 0.125) 0.049 (0.028, 0.084) 0.188 (0.13, 0.284) 0.158 (0.112, 0.239) 0.228 (0.161, 0.347) 0.036 (0.018, 0.063)
—+- graduation 0 189 82 2 0 2
—+- futility 0 23 95 55 96 23
—+- max_n 0 1 3 17 16 9
—+- n 6 (3, 9) 2 (0, 4) 2 (0, 4) 2 (0, 6) 3 (0, 5) 3 (1, 6)
—+- n_unique 5 (3, 9) 2 (0, 4) 2 (0, 4) 2 (0, 5) 2 (0, 5) 3 (1, 5)
—+- post_p NA (NA, NA) 0.59 (0.4, 0.82) 0.64 (0.41, 0.86) 0.38 (0.19, 0.56) 0.32 (0.16, 0.48) 0.36 (0.18, 0.52)
—+- rate 0.062 (0.025, 0.135) 0.055 (0, 0.189) 0.044 (0, 0.162) 0.176 (0.078, 0.542) 0.25 (0.115, 0.756) 0.201 (0.089, 0.521)
—++ graduation 0 187 84 2 0 302
—++ futility 0 31 95 123 202 20
—++ max_n 0 1 3 17 16 7
—++ n 14 (9, 19) 5 (1, 11) 6 (2, 12) 7 (3, 13) 6 (2, 11) 4 (2, 9)
—++ n_unique 13 (8, 18) 5 (1, 10) 5 (1, 11) 6 (2, 12) 5 (2, 10) 4 (1, 8)
—++ post_p NA (NA, NA) 0.56 (0.28, 0.86) 0.71 (0.36, 0.9) 0.17 (0.03, 0.4) 0.12 (0.02, 0.32) 0.78 (0.48, 0.95)
—++ rate 0.066 (0.041, 0.108) 0.068 (0.033, 0.133) 0.051 (0.023, 0.116) 0.164 (0.096, 0.309) 0.232 (0.138, 0.458) 0.036 (0.011, 0.085)
–+– graduation 0 10 25 1 0 19
–+– futility 0 105 1 79 173 1
–+– max_n 0 0 0 0 1 0
–+– n 28 (21, 35) 12 (6, 17) 12 (7, 18) 12 (7, 17) 10 (5, 17) 12 (8, 17)
–+– n_unique 25 (19, 32) 10 (5, 15) 11 (6, 16) 11 (6, 16) 9 (4, 15) 11 (7, 16)
–+– post_p NA (NA, NA) 0.48 (0.14, 0.85) 0.51 (0.18, 0.84) 0.52 (0.15, 0.86) 0.47 (0.18, 0.83) 0.51 (0.18, 0.83)
–+– rate 0.113 (0.086, 0.148) 0.115 (0.072, 0.191) 0.113 (0.076, 0.165) 0.112 (0.075, 0.188) 0.117 (0.076, 0.198) 0.112 (0.076, 0.172)
–+-+ graduation 0 11 26 1 0 309
–+-+ futility 0 111 4 121 230 1
–+-+ max_n 0 0 1 0 1 0
–+-+ n 26 (20, 33) 12 (6, 18) 13 (8, 21) 12 (5, 19) 9 (4, 16) 8 (3, 14)
–+-+ n_unique 24 (18, 31) 10 (5, 16) 12 (6, 19) 10 (5, 17) 9 (3, 15) 7 (3, 13)
–+-+ post_p NA (NA, NA) 0.46 (0.16, 0.83) 0.25 (0.05, 0.61) 0.34 (0.11, 0.74) 0.18 (0.04, 0.43) 0.99 (0.88, 1)
–+-+ rate 0.144 (0.11, 0.185) 0.147 (0.092, 0.228) 0.185 (0.125, 0.285) 0.166 (0.109, 0.258) 0.225 (0.159, 0.357) 0.038 (0.018, 0.068)
–++- graduation 0 10 101 1 0 19
–++- futility 0 120 1 106 205 1
–++- max_n 0 0 0 0 1 0
–++- n 8 (4, 12) 4 (1, 6) 3 (1, 6) 4 (1, 6) 3 (1, 6) 4 (1, 7)
–++- n_unique 7 (4, 11) 3 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.42 (0.21, 0.66) 0.76 (0.48, 0.94) 0.36 (0.16, 0.58) 0.32 (0.14, 0.5) 0.32 (0.16, 0.55)
–++- rate 0.083 (0.042, 0.153) 0.15 (0.065, 0.372) 0.037 (0, 0.118) 0.173 (0.074, 0.445) 0.244 (0.117, 0.682) 0.198 (0.094, 0.446)
–+++ graduation 0 11 102 1 0 309
–+++ futility 0 126 4 140 247 1
–+++ max_n 0 0 1 0 1 0
–+++ n 20 (14, 27) 9 (4, 15) 9 (5, 15) 9 (4, 15) 7 (3, 13) 7 (3, 13)
–+++ n_unique 18 (13, 25) 8 (4, 13) 8 (4, 13) 8 (4, 14) 6 (2, 12) 6 (2, 12)
–+++ post_p NA (NA, NA) 0.22 (0.05, 0.54) 0.87 (0.55, 0.98) 0.18 (0.04, 0.44) 0.12 (0.02, 0.32) 0.92 (0.66, 0.99)
–+++ rate 0.089 (0.061, 0.13) 0.15 (0.093, 0.259) 0.05 (0.024, 0.089) 0.16 (0.103, 0.26) 0.232 (0.138, 0.446) 0.036 (0.015, 0.073)
-+— graduation 0 198 4 179 163 1
-+— futility 0 12 141 31 45 101
-+— max_n 0 1 2 16 15 9
-+— n 26 (20, 33) 10 (3, 17) 12 (4, 18) 11 (6, 17) 11 (6, 17) 13 (7, 19)
-+— n_unique 24 (18, 31) 8 (2, 15) 10 (4, 16) 10 (5, 15) 10 (5, 16) 11 (6, 18)
-+— post_p NA (NA, NA) 0.8 (0.46, 0.97) 0.08 (0.01, 0.31) 0.95 (0.71, 1) 0.95 (0.72, 1) 0.07 (0, 0.26)
-+— rate 0.098 (0.07, 0.134) 0.056 (0.032, 0.098) 0.186 (0.133, 0.301) 0.038 (0.02, 0.069) 0.04 (0.021, 0.067) 0.188 (0.132, 0.275)
-+–+ graduation 0 196 5 177 160 253
-+–+ futility 0 21 140 95 153 96
-+–+ max_n 0 1 3 16 15 7
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.52 (0.45, 0.55) 0.51 (0.5, 0.52) 0.49 (0.49, 0.49) 0.52 (0.49, 0.55) 0.49 (0.49, 0.49)
-+–+ rate 0.167 (0, 0.864) 0.04 (0, 0.45) 0.285 (0.047, 2.196) 0 (0, 0.258) 0.044 (0, 0.678) 0.043 (0, 1.341)
-+-+- graduation 0 191 78 175 163 2
-+-+- futility 0 35 135 54 94 101
-+-+- max_n 0 1 2 16 15 9
-+-+- n 13 (8, 18) 5 (1, 9) 5 (1, 9) 6 (2, 10) 6 (2, 10) 7 (3, 11)
-+-+- n_unique 12 (8, 17) 4 (1, 9) 4 (1, 8) 5 (2, 9) 5 (2, 9) 6 (3, 10)
-+-+- post_p NA (NA, NA) 0.5 (0.2, 0.76) 0.57 (0.3, 0.84) 0.76 (0.46, 0.93) 0.74 (0.42, 0.95) 0.12 (0.02, 0.3)
-+-+- rate 0.073 (0.044, 0.116) 0.073 (0.036, 0.153) 0.059 (0.024, 0.149) 0.038 (0.015, 0.082) 0.039 (0.016, 0.092) 0.202 (0.116, 0.37)
-+-++ graduation 0 189 79 173 160 253
-+-++ futility 0 43 134 109 168 96
-+-++ max_n 0 1 3 16 15 7
-+-++ n 5 (3, 9) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5)
-+-++ n_unique 5 (2, 8) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 4) 2 (0, 4)
-+-++ post_p NA (NA, NA) 0.45 (0.28, 0.63) 0.49 (0.32, 0.68) 0.57 (0.39, 0.78) 0.56 (0.39, 0.76) 0.56 (0.38, 0.75)
-+-++ rate 0.073 (0.036, 0.163) 0.078 (0.024, 0.238) 0.063 (0, 0.192) 0.037 (0, 0.119) 0.043 (0, 0.139) 0.041 (0, 0.134)
-++– graduation 0 13 23 176 166 16
-++– futility 0 113 48 69 129 79
-++– max_n 0 0 0 0 1 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.46 (0.4, 0.52) 0.49 (0.42, 0.62) 0.44 (0.41, 0.47) 0.45 (0.44, 0.47) 0.5 (0.44, 0.54)
-++– rate 0.129 (0, 1.059) 0.115 (0.008, 0.672) 0.232 (0, 1.526) 0.051 (0, 0.19) 0.048 (0, 0.513) 0.244 (0, 1.347)
-++-+ graduation 0 14 23 175 163 260
-++-+ futility 0 119 49 104 173 77
-++-+ max_n 0 0 1 0 1 0
-++-+ n 3 (1, 6) 1 (0, 4) 2 (0, 4) 1 (0, 4) 1 (0, 3) 1 (0, 3)
-++-+ n_unique 3 (1, 6) 1 (0, 3) 1 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.44 (0.33, 0.6) 0.42 (0.28, 0.55) 0.62 (0.43, 0.81) 0.6 (0.43, 0.79) 0.58 (0.43, 0.75)
-++-+ rate 0.157 (0.07, 0.384) 0.158 (0.048, 0.571) 0.196 (0.062, 0.769) 0.035 (0, 0.175) 0.041 (0, 0.216) 0.044 (0, 0.199)
-+++- graduation 0 13 95 174 166 16
-+++- futility 0 128 48 96 160 79
-+++- max_n 0 0 0 0 1 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.44 (0.43, 0.45) 0.49 (0.47, 0.51) 0.57 (0.57, 0.57) 0.54 (0.49, 0.57) 0.53 (0.5, 0.55)
-+++- rate 0.175 (0, 1.025) 0.158 (0, 0.473) 0.072 (0, 0.545) 0 (0, 0.222) 0.121 (0, 0.693) 0.121 (0, 0.381)
-++++ graduation 0 14 95 173 163 260
-++++ futility 0 134 49 123 189 77
-++++ max_n 0 0 1 0 1 0
-++++ n 3 (1, 6) 2 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3) 1 (0, 3)
-++++ n_unique 3 (1, 6) 2 (0, 4) 1 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.41 (0.25, 0.53) 0.52 (0.38, 0.71) 0.56 (0.41, 0.74) 0.56 (0.42, 0.75) 0.56 (0.4, 0.71)
-++++ rate 0.106 (0.036, 0.275) 0.165 (0.054, 0.56) 0.062 (0, 0.263) 0.042 (0, 0.176) 0.038 (0, 0.191) 0.046 (0, 0.178)
+—- graduation 0 10 4 1 0 0
+—- futility 0 0 0 0 8 1
+—- max_n 0 0 0 0 0 0
+—- n 6 (3, 10) 2 (1, 5) 2 (1, 5) 2 (1, 5) 3 (1, 5) 3 (1, 5)
+—- n_unique 5 (3, 9) 2 (0, 4) 2 (1, 4) 2 (0, 4) 2 (0, 4) 2 (1, 4)
+—- post_p NA (NA, NA) 0.47 (0.25, 0.74) 0.49 (0.29, 0.73) 0.49 (0.27, 0.74) 0.5 (0.31, 0.74) 0.51 (0.29, 0.73)
+—- rate 0.119 (0.061, 0.232) 0.127 (0.036, 0.433) 0.12 (0.042, 0.391) 0.12 (0.04, 0.359) 0.118 (0.032, 0.341) 0.114 (0.038, 0.32)
+—+ graduation 0 12 6 1 0 305
+—+ futility 0 9 3 87 162 1
+—+ max_n 0 0 1 0 0 0
+—+ n 2 (1, 5) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 2)
+—+ n_unique 2 (1, 5) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 2)
+—+ post_p NA (NA, NA) 0.48 (0.37, 0.67) 0.46 (0.33, 0.62) 0.48 (0.34, 0.65) 0.45 (0.32, 0.61) 0.61 (0.44, 0.79)
+—+ rate 0.155 (0.064, 0.505) 0.152 (0, 0.638) 0.222 (0.062, 0.776) 0.166 (0.031, 0.912) 0.25 (0.066, 1.041) 0.054 (0, 0.243)
+–+- graduation 0 10 84 1 0 1
+–+- futility 0 23 0 36 75 1
+–+- max_n 0 0 0 0 0 0
+–+- n 9 (5, 13) 4 (1, 7) 3 (1, 6) 4 (2, 7) 4 (1, 7) 4 (2, 7)
+–+- n_unique 8 (5, 12) 3 (1, 6) 3 (1, 6) 4 (1, 6) 3 (1, 6) 3 (1, 6)
+–+- post_p NA (NA, NA) 0.41 (0.18, 0.64) 0.79 (0.52, 0.96) 0.37 (0.15, 0.62) 0.3 (0.12, 0.49) 0.32 (0.13, 0.55)
+–+- rate 0.085 (0.046, 0.147) 0.154 (0.07, 0.383) 0.041 (0, 0.097) 0.167 (0.084, 0.424) 0.231 (0.114, 0.563) 0.207 (0.101, 0.448)
+–++ graduation 0 12 86 1 0 305
+–++ futility 0 31 3 107 186 1
+–++ max_n 0 0 1 0 0 0
+–++ n 4 (2, 8) 2 (0, 5) 2 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3)
+–++ n_unique 4 (2, 7) 2 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 4) 1 (0, 3)
+–++ post_p NA (NA, NA) 0.44 (0.27, 0.6) 0.58 (0.39, 0.8) 0.42 (0.27, 0.6) 0.38 (0.21, 0.53) 0.64 (0.45, 0.84)
+–++ rate 0.102 (0.047, 0.247) 0.148 (0.06, 0.439) 0.065 (0, 0.245) 0.177 (0.065, 0.645) 0.253 (0.09, 0.849) 0.041 (0, 0.143)
+-+– graduation 0 10 25 1 0 19
+-+– futility 0 105 1 79 173 1
+-+– max_n 0 0 0 0 1 0
+-+– n 2 (0, 4) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 2 (0, 4) 0 (0, 2) 1 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.5 (0.39, 0.65) 0.48 (0.35, 0.63) 0.51 (0.36, 0.66) 0.46 (0.37, 0.59) 0.48 (0.35, 0.62)
+-+– rate 0.177 (0.048, 0.555) 0.167 (0, 0.803) 0.22 (0.053, 1.045) 0.178 (0, 1.017) 0.262 (0.088, 1.184) 0.215 (0, 1.008)
+-+-+ graduation 0 11 26 1 0 309
+-+-+ futility 0 111 4 121 230 1
+-+-+ max_n 0 0 1 0 1 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) 0.5 (0.5, 0.52) 0.53 (0.53, 0.53) 0.45 (0.45, 0.45) 0.48 (0.48, 0.48) NA (NA, NA)
+-+-+ rate 0.142 (0, 1.576) 0.126 (0, 0.753) 0.348 (0.124, 1.292) 0.178 (0, 1.135) 0.307 (0.119, 1.426) 0.055 (0, 0.138)
+-++- graduation 0 10 101 1 0 19
+-++- futility 0 120 1 106 205 1
+-++- max_n 0 0 0 0 1 0
+-++- n 22 (17, 29) 10 (5, 14) 9 (5, 15) 9 (5, 14) 8 (3, 14) 11 (6, 16)
+-++- n_unique 21 (15, 27) 8 (4, 13) 8 (4, 14) 8 (4, 13) 7 (3, 13) 10 (5, 14)
+-++- post_p NA (NA, NA) 0.27 (0.08, 0.62) 0.96 (0.75, 1) 0.2 (0.04, 0.47) 0.11 (0.02, 0.31) 0.11 (0.02, 0.42)
+-++- rate 0.082 (0.059, 0.118) 0.14 (0.093, 0.235) 0.038 (0.018, 0.071) 0.172 (0.11, 0.277) 0.232 (0.15, 0.418) 0.19 (0.122, 0.284)
+-+++ graduation 0 11 102 1 0 309
+-+++ futility 0 126 4 140 247 1
+-+++ max_n 0 0 1 0 1 0
+-+++ n 17 (12, 23) 8 (3, 14) 8 (4, 14) 8 (3, 13) 6 (2, 12) 5 (2, 11)
+-+++ n_unique 16 (11, 21) 7 (3, 12) 7 (3, 12) 7 (3, 12) 5 (2, 10) 5 (2, 10)
+-+++ post_p NA (NA, NA) 0.29 (0.09, 0.61) 0.82 (0.46, 0.97) 0.24 (0.06, 0.49) 0.16 (0.03, 0.38) 0.9 (0.65, 0.99)
+-+++ rate 0.099 (0.067, 0.141) 0.147 (0.09, 0.252) 0.059 (0.031, 0.108) 0.164 (0.107, 0.301) 0.238 (0.139, 0.405) 0.037 (0.013, 0.078)
++— graduation 0 13 4 185 168 0
++— futility 0 12 47 0 8 79
++— max_n 0 0 0 0 0 0
++— n 9 (6, 14) 4 (2, 7) 4 (2, 7) 4 (2, 7) 4 (1, 7) 4 (2, 7)
++— n_unique 9 (5, 13) 3 (1, 6) 4 (1, 7) 3 (1, 6) 3 (1, 6) 4 (1, 6)
++— post_p NA (NA, NA) 0.44 (0.22, 0.68) 0.33 (0.14, 0.57) 0.84 (0.55, 0.97) 0.83 (0.58, 0.96) 0.33 (0.15, 0.57)
++— rate 0.149 (0.095, 0.251) 0.146 (0.072, 0.326) 0.21 (0.102, 0.48) 0.038 (0, 0.105) 0.041 (0, 0.097) 0.197 (0.096, 0.475)
++–+ graduation 0 15 5 183 165 256
++–+ futility 0 21 48 72 130 77
++–+ max_n 0 0 1 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.48 (0.45, 0.52) 0.52 (0.49, 0.55) 0.57 (0.57, 0.57) 0.51 (0.48, 0.54) 0.56 (0.56, 0.56)
++–+ rate 0.201 (0.037, 0.738) 0.312 (0.022, 1.218) 0.305 (0.013, 3.712) 0.066 (0, 0.537) 0.047 (0, 0.293) 0 (0, 0.256)
++-+- graduation 0 13 80 183 168 1
++-+- futility 0 35 47 35 73 79
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 1)
++-+- post_p NA (NA, NA) 0.47 (0.39, 0.58) 0.54 (0.43, 0.65) 0.55 (0.42, 0.64) 0.54 (0.44, 0.63) 0.44 (0.36, 0.54)
++-+- rate 0.121 (0, 0.444) 0.149 (0, 0.625) 0.05 (0, 0.305) 0.021 (0, 0.214) 0.026 (0, 0.23) 0.243 (0, 1.178)
++-++ graduation 0 15 81 181 165 256
++-++ futility 0 43 48 92 152 77
++-++ max_n 0 0 1 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) 0.48 (0.48, 0.48) 0.48 (0.48, 0.48) 0.57 (0.54, 0.61) 0.55 (0.55, 0.55) 0.51 (0.44, 0.59)
++-++ rate 0.248 (0, 1.234) 0.283 (0.101, 1.32) 0.083 (0, 0.248) 0.036 (0, 0.234) 0.016 (0, 0.126) 0.093 (0, 0.22)
+++– graduation 0 13 23 176 166 16
+++– futility 0 113 48 69 129 79
+++– max_n 0 0 0 0 1 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1)
+++– post_p NA (NA, NA) 0.53 (0.45, 0.58) 0.46 (0.41, 0.57) 0.55 (0.48, 0.6) 0.54 (0.51, 0.62) 0.48 (0.43, 0.57)
+++– rate 0.207 (0.047, 1.078) 0.147 (0, 0.734) 0.255 (0, 1.371) 0 (0, 0.2) 0.042 (0, 0.422) 0.242 (0, 1.094)
+++-+ graduation 0 14 23 175 163 260
+++-+ futility 0 119 49 104 173 77
+++-+ max_n 0 0 1 0 1 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.55 (0.54, 0.56) 0.5 (0.47, 0.55) 0.54 (0.46, 0.58) 0.54 (0.54, 0.54) 0.52 (0.51, 0.54)
+++-+ rate 0.163 (0, 0.943) 0.071 (0, 0.877) 0.288 (0, 1.242) 0 (0, 0.154) 0 (0, 0.081) 0.057 (0, 0.344)
++++- graduation 0 13 95 174 166 16
++++- futility 0 128 48 96 160 79
++++- max_n 0 0 0 0 1 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) 0.46 (0.42, 0.5) 0.52 (0.48, 0.55) 0.52 (0.5, 0.54) NA (NA, NA) NA (NA, NA)
++++- rate 0.088 (0, 0.293) 0.115 (0, 0.607) 0.099 (0, 0.621) 0.076 (0, 0.653) 0 (0, 0.146) 0.192 (0.026, 0.352)
+++++ graduation 0 14 95 173 163 260
+++++ futility 0 134 49 123 189 77
+++++ max_n 0 0 1 0 1 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.46 (0.42, 0.49) 0.58 (0.51, 0.6) 0.48 (0.48, 0.48) 0.49 (0.48, 0.5) 0.68 (0.68, 0.68)
+++++ rate 0.132 (0, 0.923) 0.063 (0, 0.453) 0 (0, 0.295) 0 (0, 0.167) 0.064 (0, 0.658) 0.022 (0, 0.148)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 10 4 1
all time_stop 6 (5, 8) 6 (4, 7) 6 (6, 6)
all n_trt 30 (25, 32) 29 (26, 34) 25 (25, 25)
all n_control 50 (35, 74) 48 (34, 56) 49 (49, 49)
all post_p 0.93 (0.88, 1) 0.95 (0.93, 0.96) 0.89 (0.89, 0.89)
all order 1 (1, 1) 1 (1, 1) 1 (1, 1)
AR- & TP53- count 186 3 1
AR- & TP53- time_stop 12 (9, 24) 7 (6, 12) 11 (11, 11)
AR- & TP53- n_trt 30 (25, 64) 28 (26, 28) 25 (25, 25)
AR- & TP53- n_control 69 (44, 150) 43 (25, 73) 64 (64, 64)
AR- & TP53- post_p 0.99 (0.95, 1) 0.9 (0.89, 0.94) 0.96 (0.96, 0.96)
AR- & TP53- order 1 (1, 2) 1 (1, 1) 1 (1, 1)
HRD+ count 3 184 168
HRD+ time_stop 32 (30, 32) 29 (21, 35) 30 (23, 35)
HRD+ n_trt 29 (26, 31) 26 (25, 32) 26 (25, 31)
HRD+ n_control 56 (52, 66) 50 (36, 66) 53 (38, 68)
HRD+ post_p 0.94 (0.93, 0.94) 1 (0.98, 1) 1 (0.98, 1)
HRD+ order 2 (1.2, 2.8) 2 (1, 3) 2 (1, 4)
TP53+ count 21 19
TP53+ time_stop 20 (15, 24) 15 (14, 25)
TP53+ n_trt 29 (25, 38) 26 (25, 36)
TP53+ n_control 70 (49, 97) 53 (39, 77)
TP53+ post_p 0.98 (0.94, 1) 0.98 (0.96, 1)
TP53+ order 2 (1, 3) 1 (1, 2.2)
TEfus+ count 80 1
TEfus+ time_stop 19 (14, 28) 15 (15, 15)
TEfus+ n_trt 30 (25, 51) 30 (30, 30)
TEfus+ n_control 62 (43, 100) 41 (41, 41)
TEfus+ post_p 0.99 (0.96, 1) 0.98 (0.98, 0.98)
TEfus+ order 2 (1, 3) 2 (2, 2)
PI3K+ count 2 2 305
PI3K+ time_stop 18 (14, 22) 18 (14, 21) 19 (14, 28)
PI3K+ n_trt 30 (26, 34) 27 (26, 28) 28 (25, 52)
PI3K+ n_control 57 (45, 69) 61 (45, 77) 64 (46, 102)
PI3K+ post_p 0.98 (0.96, 0.99) 0.95 (0.92, 0.98) 1 (0.99, 1)
PI3K+ order 2.5 (2.1, 2.9) 2.5 (2.1, 2.9) 1 (1, 2)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 8 1
all time_stop 6 (6, 7) 4 (4, 4)
all n_trt 34 (25, 36) 28 (28, 28)
all n_control 52 (45, 74) 34 (34, 34)
all post_p 0.01 (0, 0.2) 0.08 (0.08, 0.08)
all order 1 (1, 1) 1 (1, 1)
AR- & TP53- count 101 31 38 22
AR- & TP53- time_stop 13 (8, 22) 12 (9, 17) 11 (8, 16) 12 (8, 18)
AR- & TP53- n_trt 31 (25, 55) 29 (25, 42) 27 (25, 43) 30 (26, 47)
AR- & TP53- n_control 72 (40, 134) 61 (49, 97) 58 (40, 101) 66 (36, 101)
AR- & TP53- post_p 0.03 (0, 0.16) 0.05 (0, 0.16) 0.02 (0, 0.1) 0.05 (0.01, 0.16)
AR- & TP53- order 1 (1, 2) 1 (1, 2) 1 (1, 2) 1 (1, 2)
HRD+ count 12 47 78
HRD+ time_stop 28 (22, 35) 30 (24, 35) 30 (24, 34)
HRD+ n_trt 27 (25, 30) 27 (25, 35) 26 (25, 33)
HRD+ n_control 48 (36, 63) 52 (42, 67) 52 (38, 63)
HRD+ post_p 0.09 (0.04, 0.19) 0.04 (0, 0.21) 0.02 (0, 0.14)
HRD+ order 2 (1, 4) 2 (1, 4) 2 (1, 4)
TP53+ count 105 1 79 165
TP53+ time_stop 21 (13, 32) 18 (18, 18) 20 (15, 31) 20 (13, 30)
TP53+ n_trt 36 (26, 54) 28 (28, 28) 34 (25, 57) 28 (25, 44)
TP53+ n_control 76 (44, 114) 63 (63, 63) 76 (48, 117) 71 (47, 111)
TP53+ post_p 0.04 (0.01, 0.14) 0.06 (0.06, 0.06) 0.04 (0, 0.13) 0.02 (0, 0.07)
TP53+ order 2 (1, 4) 1 (1, 1) 2 (1, 4) 2 (1, 4)
TEfus+ count 23 36 67
TEfus+ time_stop 24 (16, 34) 22 (16, 30) 22 (16, 29)
TEfus+ n_trt 35 (26, 58) 31 (26, 43) 31 (25, 43)
TEfus+ n_control 92 (56, 121) 82 (46, 110) 75 (50, 104)
TEfus+ post_p 0.01 (0, 0.09) 0.01 (0, 0.06) 0 (0, 0.05)
TEfus+ order 3 (1, 5) 2 (1, 4) 2 (1, 4)
PI3K+ count 9 3 87 154
PI3K+ time_stop 18 (12, 34) 15 (13, 25) 20 (14, 30) 19 (13, 27)
PI3K+ n_trt 28 (25, 50) 27 (26, 33) 29 (25, 51) 27 (25, 43)
PI3K+ n_control 71 (41, 118) 50 (42, 103) 70 (47, 104) 67 (44, 102)
PI3K+ post_p 0.08 (0.04, 0.23) 0.12 (0.09, 0.18) 0.04 (0, 0.13) 0.01 (0, 0.07)
PI3K+ order 2 (1, 3) 2 (2, 2.8) 2 (1, 4) 2 (1, 3.7)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
all TC1 time 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8)
all TC1 n 11 (6, 13) 4 (1, 4) 1 (0, 1) 1 (0, 4) 2 (1, 3) 2 (0, 4) 0 (0, 1) 2 (0, 2) 2 (1, 4) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 2 (0, 3) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.93 (0.64, 0.96) 0.54 (0.5, 0.61) 0.54 (0.51, 0.61) 0.53 (0.51, 0.57) 0.54 (0.51, 0.65) 0.54 (0.53, 0.62) 0.53 (0.52, 0.54) 0.58 (0.53, 0.66) 0.53 (0.52, 0.57) NA (NA, NA) 0.5 (0.5, 0.54) 0.54 (0.53, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) 0.54 (0.52, 0.6) NA (NA, NA) 0.51 (0.5, 0.55) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) 0.59 (0.53, 0.64) 0.57 (0.53, 0.61) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.027 (0, 0.049) 0.031 (0, 0.115) 0 (0, 0.097) 0 (0, 0) 0 (0, 0.067) 0.022 (0, 0.148) 0 (0, 0) 0 (0, 0.031) 0 (0, 0.076) NA (NA, NA) 0 (0, 0.143) 0 (0, 1.286) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.124) 0.426 (0.426, 0.426) 0 (0, 0.085) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0.15) 0 (0, 0.503) 0 (0, 0.601) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC2 time 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7)
all TC2 n 9 (5, 12) 2 (0, 4) 0 (0, 1) 0 (0, 2) 2 (2, 3) 2 (1, 4) 0 (0, 1) 0 (0, 1) 2 (1, 3) 0 (0, 0) 2 (1, 3) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 1 (0, 1) 0 (0, 0) 0 (0, 0) 3 (2, 5) 2 (1, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.63 (0.53, 0.68) 0.53 (0.51, 0.56) NA (NA, NA) 0.53 (0.53, 0.53) 0.62 (0.58, 0.67) 0.56 (0.55, 0.58) 0.54 (0.53, 0.56) 0.53 (0.53, 0.53) 0.54 (0.51, 0.54) NA (NA, NA) 0.53 (0.53, 0.53) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) 0.55 (0.54, 0.55) 0.55 (0.55, 0.55) 0.55 (0.54, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.09 (0.023, 0.117) 0 (0, 0.088) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.065) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.859) NA (NA, NA) NA (NA, NA) 0 (0, 0.03) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC3 time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
all TC3 n 5 (5, 5) 6 (6, 6) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 3 (3, 3) 4 (4, 4) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.64 (0.64, 0.64) 0.6 (0.6, 0.6) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.6 (0.6, 0.6) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.058 (0.058, 0.058) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.086 (0.086, 0.086) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.128 (0.128, 0.128) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 186 186 186 186 186 186 186 186
AR- & TP53- TC1 time 12 (9, 24) 12 (9, 24) 12 (9, 24) 12 (9, 24) 12 (9, 24) 12 (9, 24) 12 (9, 24) 12 (9, 24)
AR- & TP53- TC1 n 17 (13, 34) 5 (2, 10) 1 (0, 2) 2 (0, 5) 4 (2, 9) 0 (0, 0) 2 (0, 5) 1 (0, 2)
AR- & TP53- TC1 post_p 0.97 (0.86, 1) 0.72 (0.55, 0.93) 0.56 (0.51, 0.72) 0.55 (0.51, 0.72) 0.66 (0.53, 0.87) 0.52 (0.52, 0.52) 0.55 (0.51, 0.65) 0.54 (0.51, 0.61)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.037 (0.013, 0.066) 0.032 (0, 0.08) 0 (0, 0.084) 0.036 (0, 0.088) 0.029 (0, 0.081) 0.143 (0.029, 0.258) 0 (0, 0.074) 0 (0, 0.213)
AR- & TP53- TC3 count 3 3 3 3 3 3 3 3
AR- & TP53- TC3 time 7 (6, 12) 7 (6, 12) 7 (6, 12) 7 (6, 12) 7 (6, 12) 7 (6, 12) 7 (6, 12) 7 (6, 12)
AR- & TP53- TC3 n 16 (14, 18) 3 (1, 5) 1 (1, 1) 1 (0, 3) 5 (3, 5) 0 (0, 0) 1 (1, 2) 0 (0, 0)
AR- & TP53- TC3 post_p 0.79 (0.73, 0.87) 0.61 (0.57, 0.64) 0.52 (0.51, 0.53) 0.52 (0.51, 0.53) 0.67 (0.58, 0.69) NA (NA, NA) 0.52 (0.52, 0.57) NA (NA, NA)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.072 (0.067, 0.077) 0 (0, 0.167) 0 (0, 0) 0.048 (0.01, 0.087) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA)
AR- & TP53- TC5 count 1 1 1 1 1 1 1 1
AR- & TP53- TC5 time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
AR- & TP53- TC5 n 12 (12, 12) 8 (8, 8) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 3 (3, 3)
AR- & TP53- TC5 post_p 0.83 (0.83, 0.83) 0.77 (0.77, 0.77) NA (NA, NA) 0.54 (0.54, 0.54) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.122 (0.122, 0.122) 0.05 (0.05, 0.05) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.048 (0.048, 0.048)
HRD+ TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
HRD+ TC1 time 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32) 32 (30, 32)
HRD+ TC1 n 14 (13, 14) 0 (0, 0) 6 (5, 8) 4 (2, 5) 0 (0, 0) 2 (0, 3) 0 (0, 0) 1 (0, 1) 3 (1, 4) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.84 (0.75, 0.86) NA (NA, NA) 0.76 (0.68, 0.76) 0.59 (0.58, 0.59) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) 0.59 (0.54, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.054 (0.046, 0.057) NA (NA, NA) 0.044 (0.032, 0.054) 0.053 (0.011, 0.057) NA (NA, NA) 0.052 (0.01, 0.093) NA (NA, NA) 0.115 (0.023, 0.207) 0.097 (0.078, 0.116) NA (NA, NA) 0.078 (0.078, 0.078) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 184 184 184 184 184 184 184 184 184 184 184 184 184 184 184 184
HRD+ TC3 time 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35)
HRD+ TC3 n 11 (7, 15) 0 (0, 0) 5 (3, 8) 2 (0, 5) 0 (0, 0) 2 (0, 3) 0 (0, 0) 2 (0, 4) 3 (1, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.94 (0.75, 0.99) 0.5 (0.5, 0.5) 0.75 (0.61, 0.9) 0.59 (0.52, 0.76) NA (NA, NA) 0.62 (0.53, 0.75) NA (NA, NA) 0.58 (0.51, 0.7) 0.78 (0.58, 0.95) NA (NA, NA) 0.58 (0.52, 0.64) NA (NA, NA) 0.57 (0.55, 0.59) 0.54 (0.54, 0.54) NA (NA, NA) 0.51 (0.51, 0.51)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.035 (0.014, 0.063) 0.198 (0.062, 1.818) 0.03 (0, 0.058) 0.013 (0, 0.059) 0 (0, 0.057) 0 (0, 0.104) 0 (0, 0.272) 0.026 (0, 0.085) 0.032 (0, 0.092) 0 (0, 0.051) 0 (0, 0.106) 0 (0, 0.182) 0 (0, 0.156) 0 (0, 0.056) 0 (0, 0.436) 0 (0, 0.042)
HRD+ TC4 count 168 168 168 168 168 168 168 168 168 168 168 168 168 168 168 168
HRD+ TC4 time 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35)
HRD+ TC4 n 11 (7, 15) 0 (0, 0) 6 (3, 9) 2 (0, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 4 (2, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.93 (0.77, 0.99) 0.55 (0.55, 0.55) 0.78 (0.58, 0.92) 0.57 (0.51, 0.71) 0.51 (0.51, 0.51) 0.59 (0.52, 0.77) NA (NA, NA) 0.59 (0.52, 0.76) 0.82 (0.59, 0.96) 0.51 (0.51, 0.51) 0.57 (0.52, 0.65) NA (NA, NA) 0.59 (0.52, 0.67) NA (NA, NA) NA (NA, NA) 0.52 (0.51, 0.52)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.038 (0.017, 0.059) 0.021 (0, 0.967) 0.03 (0.012, 0.058) 0.026 (0, 0.068) 0 (0, 0.264) 0 (0, 0.093) 0.09 (0, 0.821) 0 (0, 0.08) 0.037 (0, 0.082) 0.723 (0.145, 1.301) 0 (0, 0.183) 0.139 (0.113, 0.165) 0.055 (0, 1.315) 0.026 (0.005, 0.047) 0.033 (0.007, 0.059) 0.086 (0, 2.728)
TP53+ TC2 count 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21
TP53+ TC2 time 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24)
TP53+ TC2 n 5 (3, 12) 5 (3, 9) 2 (0, 5) 4 (2, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 5 (2, 7) 3 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.72 (0.57, 0.82) 0.63 (0.53, 0.76) 0.62 (0.53, 0.76) 0.74 (0.62, 0.91) NA (NA, NA) 0.53 (0.52, 0.54) NA (NA, NA) 0.54 (0.51, 0.6) 0.55 (0.51, 0.59) NA (NA, NA) 0.82 (0.59, 0.92) 0.82 (0.56, 0.93) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.072 (0.027, 0.093) 0.106 (0.065, 0.128) 0.038 (0, 0.131) 0.04 (0, 0.098) NA (NA, NA) 0.114 (0, 1.064) NA (NA, NA) 0 (0, 0.196) 0.1 (0, 8.222) NA (NA, NA) 0.037 (0, 0.059) 0.027 (0, 0.068) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TP53+ TC5 count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
TP53+ TC5 time 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25) 15 (14, 25)
TP53+ TC5 n 5 (3, 10) 6 (3, 10) 1 (0, 3) 4 (2, 8) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 4 (2, 6) 4 (2, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.7 (0.53, 0.75) 0.89 (0.74, 0.98) 0.57 (0.53, 0.69) 0.73 (0.6, 0.95) NA (NA, NA) 0.55 (0.52, 0.72) NA (NA, NA) 0.58 (0.55, 0.63) 0.57 (0.53, 0.67) NA (NA, NA) 0.55 (0.51, 0.73) 0.73 (0.59, 0.86) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.078 (0.043, 0.11) 0.031 (0, 0.067) 0.064 (0, 0.139) 0.026 (0, 0.069) NA (NA, NA) 0 (0, 0.099) NA (NA, NA) 0 (0, 0.1) 0.169 (0, 0.249) NA (NA, NA) 0.086 (0.042, 0.131) 0.017 (0, 0.068) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80
TEfus+ TC2 time 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28)
TEfus+ TC2 n 1 (0, 3) 3 (1, 7) 2 (0, 5) 6 (3, 10) 3 (1, 5) 2 (0, 3) 0 (0, 0) 1 (0, 3) 2 (0, 4) 1 (0, 3) 6 (3, 11) 4 (2, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.61 (0.53, 0.77) 0.64 (0.53, 0.82) 0.64 (0.53, 0.86) 0.76 (0.58, 0.92) 0.59 (0.52, 0.81) 0.55 (0.51, 0.65) NA (NA, NA) 0.55 (0.51, 0.65) 0.65 (0.54, 0.85) 0.59 (0.52, 0.69) 0.84 (0.68, 0.97) 0.72 (0.54, 0.89) 0.52 (0.5, 0.58) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0 (0, 0.098) 0.038 (0, 0.085) 0.023 (0, 0.09) 0.031 (0, 0.082) 0.026 (0, 0.083) 0 (0, 0.117) 0 (0, 0) 0 (0, 0.108) 0.015 (0, 0.089) 0 (0, 0.125) 0.034 (0, 0.073) 0.043 (0, 0.088) 0 (0, 0.381) 0.191 (0.167, 0.216) 0.152 (0.03, 0.274) NA (NA, NA)
TEfus+ TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC5 time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
TEfus+ TC5 n 1 (1, 1) 1 (1, 1) 0 (0, 0) 8 (8, 8) 3 (3, 3) 2 (2, 2) 0 (0, 0) 3 (3, 3) 1 (1, 1) 0 (0, 0) 5 (5, 5) 6 (6, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p NA (NA, NA) 0.61 (0.61, 0.61) NA (NA, NA) 0.84 (0.84, 0.84) 0.59 (0.59, 0.59) 0.58 (0.58, 0.58) NA (NA, NA) 0.58 (0.58, 0.58) 0.59 (0.59, 0.59) NA (NA, NA) 0.55 (0.55, 0.55) 0.73 (0.73, 0.73) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 9.681 (9.681, 9.681) 0 (0, 0) NA (NA, NA) 0.033 (0.033, 0.033) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.113 (0.113, 0.113) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC1 time 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22) 18 (14, 22)
PI3K+ TC1 n 6 (5, 7) 5 (5, 5) 8 (5, 12) 4 (4, 4) 0 (0, 0) 0 (0, 1) 0 (0, 1) 2 (1, 2) 0 (0, 1) 1 (1, 1) 0 (0, 0) 2 (1, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.82 (0.69, 0.95) 0.59 (0.59, 0.59) 0.69 (0.55, 0.83) 0.72 (0.63, 0.8) NA (NA, NA) 0.5 (0.5, 0.5) 0.51 (0.51, 0.51) 0.54 (0.54, 0.54) 0.59 (0.59, 0.59) 0.57 (0.55, 0.6) NA (NA, NA) 0.59 (0.58, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.036 (0.016, 0.056) 0.027 (0.005, 0.048) 0.13 (0.094, 0.165) 0.034 (0.007, 0.06) NA (NA, NA) 0 (0, 0) 0.209 (0.209, 0.209) 0.302 (0.195, 0.41) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.034 (0.007, 0.062) NA (NA, NA) 0.853 (0.853, 0.853) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC2 time 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21)
PI3K+ TC2 n 6 (3, 8) 6 (3, 8) 4 (3, 5) 2 (1, 4) 0 (0, 1) 2 (2, 3) 0 (0, 1) 0 (0, 1) 1 (1, 1) 1 (1, 1) 0 (0, 0) 4 (3, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.73 (0.71, 0.74) 0.78 (0.64, 0.92) 0.54 (0.51, 0.57) 0.62 (0.6, 0.63) NA (NA, NA) 0.54 (0.53, 0.55) NA (NA, NA) NA (NA, NA) 0.56 (0.53, 0.59) 0.56 (0.52, 0.6) NA (NA, NA) 0.64 (0.6, 0.68) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.048 (0.01, 0.086) 0.011 (0.002, 0.02) 0.104 (0.099, 0.109) 0.05 (0.01, 0.091) 1.026 (1.026, 1.026) 0.038 (0.008, 0.069) 0.346 (0.346, 0.346) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.041 (0.008, 0.074) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 305 305 305 305 305 305 305 305 305 305 305 305 305 305 305 305
PI3K+ TC5 time 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28) 19 (14, 28)
PI3K+ TC5 n 7 (4, 13) 3 (1, 7) 6 (3, 11) 5 (2, 9) 0 (0, 0) 1 (0, 3) 1 (0, 2) 1 (0, 3) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.89 (0.72, 0.99) 0.66 (0.53, 0.88) 0.9 (0.7, 0.99) 0.78 (0.58, 0.96) NA (NA, NA) 0.55 (0.51, 0.65) 0.56 (0.52, 0.66) 0.56 (0.51, 0.64) 0.56 (0.52, 0.69) 0.58 (0.52, 0.73) NA (NA, NA) 0.74 (0.56, 0.92) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.031 (0, 0.062) 0.02 (0, 0.068) 0.037 (0, 0.084) 0.028 (0, 0.07) 0 (0, 0) 0 (0, 0.077) 0 (0, 0.117) 0 (0, 0.088) 0 (0, 0.137) 0 (0, 0.098) 0 (0, 0.255) 0.03 (0, 0.073) 0 (0, 0.102) 0.081 (0.081, 0.081) 0.119 (0, 0.346) 0 (0, 0.176)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC4 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
all TC4 time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
all TC4 n 12 (6, 16) 2 (1, 4) 1 (0, 1) 0 (0, 3) 1 (0, 4) 2 (0, 3) 0 (0, 1) 2 (1, 4) 2 (0, 3) 0 (0, 0) 2 (0, 4) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 2 (1, 2) 2 (0, 3) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.29 (0.05, 0.43) 0.4 (0.34, 0.46) 0.42 (0.39, 0.45) 0.28 (0.24, 0.38) 0.42 (0.38, 0.45) 0.43 (0.34, 0.45) 0.44 (0.42, 0.45) 0.42 (0.35, 0.49) 0.45 (0.41, 0.47) NA (NA, NA) 0.49 (0.47, 0.5) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) 0.44 (0.42, 0.46) 0.39 (0.39, 0.39) 0.39 (0.39, 0.39) NA (NA, NA) 0.38 (0.3, 0.44) 0.43 (0.38, 0.47) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.221 (0.161, 0.534) 0.269 (0.097, 0.645) 0.459 (0.266, 1.065) 0.916 (0.626, 2.501) 0.14 (0.103, 7.729) 0.435 (0.289, 0.669) 0.396 (0.058, 2.14) 0.204 (0.054, 1.17) 0.143 (0.04, 0.461) NA (NA, NA) 0.039 (0, 0.219) 0 (0, 0) NA (NA, NA) 0.13 (0.026, 0.234) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 9.948 (0.365, 19.788) 0.572 (0.572, 0.572) 0.145 (0.029, 0.261) NA (NA, NA) 0.303 (0.193, 1.495) 0.22 (0.143, 0.288) 0.082 (0.016, 0.148) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
all TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC5 time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
all TC5 n 11 (11, 11) 2 (2, 2) 2 (2, 2) 1 (1, 1) 2 (2, 2) 1 (1, 1) 1 (1, 1) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 3 (3, 3) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.4 (0.4, 0.4) 0.46 (0.46, 0.46) 0.44 (0.44, 0.44) NA (NA, NA) 0.49 (0.49, 0.49) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.19 (0.19, 0.19) 0.377 (0.377, 0.377) 0.24 (0.24, 0.24) 0 (0, 0) 0 (0, 0) 0 (0, 0) 3.277 (3.277, 3.277) NA (NA, NA) 0.39 (0.39, 0.39) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.316 (0.316, 0.316) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC2 count 101 101 101 101 101 101 101 101
AR- & TP53- TC2 time 13 (8, 22) 13 (8, 22) 13 (8, 22) 13 (8, 22) 13 (8, 22) 13 (8, 22) 13 (8, 22) 13 (8, 22)
AR- & TP53- TC2 n 19 (14, 30) 5 (2, 10) 0 (0, 2) 2 (0, 4) 4 (2, 9) 0 (0, 0) 2 (0, 5) 1 (0, 3)
AR- & TP53- TC2 post_p 0.1 (0.01, 0.37) 0.37 (0.12, 0.48) 0.45 (0.37, 0.5) 0.46 (0.36, 0.5) 0.35 (0.1, 0.46) NA (NA, NA) 0.44 (0.38, 0.48) 0.45 (0.36, 0.49)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.183 (0.125, 0.263) 0.198 (0.111, 0.408) 0.111 (0, 0.496) 0.112 (0.042, 0.359) 0.179 (0.113, 0.429) 0 (0, 0.351) 0.125 (0.029, 0.351) 0.066 (0, 0.511)
AR- & TP53- TC3 count 31 31 31 31 31 31 31 31
AR- & TP53- TC3 time 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17)
AR- & TP53- TC3 n 18 (13, 26) 5 (3, 7) 1 (0, 2) 2 (0, 5) 3 (1, 7) 0 (0, 0) 1 (0, 3) 0 (0, 2)
AR- & TP53- TC3 post_p 0.17 (0.02, 0.34) 0.35 (0.15, 0.48) 0.43 (0.38, 0.46) 0.38 (0.31, 0.44) 0.44 (0.35, 0.49) NA (NA, NA) 0.43 (0.39, 0.48) 0.45 (0.39, 0.48)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.163 (0.127, 0.25) 0.175 (0.12, 0.365) 0.43 (0.153, 2.226) 0.2 (0.071, 0.597) 0.111 (0.059, 0.426) NA (NA, NA) 0.144 (0.05, 0.395) 0.072 (0, 0.263)
AR- & TP53- TC4 count 38 38 38 38 38 38 38 38
AR- & TP53- TC4 time 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16)
AR- & TP53- TC4 n 16 (12, 27) 4 (3, 7) 1 (0, 2) 2 (0, 4) 3 (1, 7) 0 (0, 0) 2 (0, 4) 1 (0, 1)
AR- & TP53- TC4 post_p 0.08 (0, 0.28) 0.31 (0.12, 0.43) 0.42 (0.36, 0.46) 0.36 (0.26, 0.47) 0.45 (0.4, 0.49) NA (NA, NA) 0.44 (0.36, 0.49) 0.47 (0.43, 0.49)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.205 (0.164, 0.318) 0.234 (0.149, 0.494) 0.28 (0.115, 2.45) 0.293 (0.132, 0.991) 0.097 (0.053, 0.33) 0 (0, 0) 0.116 (0, 0.396) 0.043 (0, 0.452)
AR- & TP53- TC5 count 22 22 22 22 22 22 22 22
AR- & TP53- TC5 time 12 (8, 18) 12 (8, 18) 12 (8, 18) 12 (8, 18) 12 (8, 18) 12 (8, 18) 12 (8, 18) 12 (8, 18)
AR- & TP53- TC5 n 16 (13, 23) 4 (1, 7) 1 (0, 2) 2 (0, 4) 5 (2, 7) 0 (0, 0) 2 (0, 5) 0 (0, 4)
AR- & TP53- TC5 post_p 0.16 (0.02, 0.33) 0.44 (0.38, 0.48) 0.43 (0.28, 0.47) 0.45 (0.34, 0.49) 0.34 (0.14, 0.48) NA (NA, NA) 0.36 (0.21, 0.41) 0.45 (0.43, 0.49)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.183 (0.144, 0.218) 0.142 (0.09, 0.291) 0.179 (0.137, 0.585) 0.106 (0.054, 0.341) 0.202 (0.114, 0.379) 1.194 (1.194, 1.194) 0.224 (0.127, 0.77) 0.099 (0.029, 0.158)
HRD+ TC1 count 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
HRD+ TC1 time 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35)
HRD+ TC1 n 12 (9, 13) 0 (0, 1) 6 (3, 8) 2 (1, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 2 (0, 4) 4 (2, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.4 (0.19, 0.47) NA (NA, NA) 0.36 (0.21, 0.46) 0.43 (0.29, 0.49) NA (NA, NA) 0.46 (0.36, 0.49) NA (NA, NA) 0.38 (0.27, 0.44) 0.33 (0.09, 0.43) NA (NA, NA) 0.44 (0.43, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.11 (0.084, 0.137) 0 (0, 0) 0.12 (0.061, 0.223) 0.091 (0.073, 0.228) NA (NA, NA) 0.171 (0.046, 0.405) 0.306 (0.306, 0.306) 0.204 (0.133, 0.609) 0.241 (0.154, 0.315) NA (NA, NA) 0.346 (0.333, 0.465) NA (NA, NA) 0 (0, 0) 0.083 (0.083, 0.083) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 47 47 47 47 47 47 47 47 47 47 47 47 47 47 47 47
HRD+ TC2 time 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35)
HRD+ TC2 n 12 (9, 16) 0 (0, 0) 5 (3, 9) 3 (0, 5) 0 (0, 0) 1 (0, 4) 0 (0, 0) 1 (0, 4) 4 (2, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.1 (0.02, 0.3) NA (NA, NA) 0.4 (0.23, 0.49) 0.44 (0.31, 0.49) NA (NA, NA) 0.42 (0.3, 0.48) NA (NA, NA) 0.45 (0.37, 0.49) 0.32 (0.17, 0.46) NA (NA, NA) 0.45 (0.42, 0.48) 0.46 (0.46, 0.46) 0.41 (0.41, 0.41) 0.49 (0.49, 0.49) NA (NA, NA) 0.44 (0.44, 0.44)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.188 (0.139, 0.278) 0.714 (0.121, 2.956) 0.084 (0.055, 0.227) 0.092 (0.042, 0.722) 0.188 (0.082, 0.294) 0.25 (0.122, 1.197) 0 (0, 0) 0.123 (0.046, 0.418) 0.225 (0.125, 0.423) 0.305 (0.026, 3.399) 0.107 (0.01, 1.346) 0.043 (0.009, 0.077) 0.747 (0.271, 9.339) 0.055 (0, 1.548) 0.093 (0.066, 0.12) 0.054 (0.011, 0.097)
HRD+ TC5 count 78 78 78 78 78 78 78 78 78 78 78 78 78 78 78 78
HRD+ TC5 time 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34) 30 (24, 34)
HRD+ TC5 n 12 (8, 17) 0 (0, 0) 6 (3, 10) 1 (0, 4) 0 (0, 0) 0 (0, 3) 0 (0, 0) 1 (0, 3) 4 (2, 7) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.09 (0.01, 0.26) NA (NA, NA) 0.16 (0.04, 0.3) 0.44 (0.35, 0.49) NA (NA, NA) 0.47 (0.41, 0.5) NA (NA, NA) 0.44 (0.39, 0.47) 0.37 (0.14, 0.47) NA (NA, NA) 0.45 (0.41, 0.48) NA (NA, NA) 0.46 (0.45, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.181 (0.135, 0.282) 0.096 (0.096, 0.096) 0.212 (0.128, 0.371) 0.07 (0.039, 0.286) 1.183 (1.183, 1.183) 0.116 (0.046, 0.277) 0.063 (0, 0.393) 0.1 (0.024, 0.567) 0.22 (0.123, 0.518) 0.068 (0.068, 0.068) 0.371 (0.102, 1.589) NA (NA, NA) 0.199 (0.072, 0.547) 0.422 (0.422, 0.422) 0.244 (0.154, 1.198) 0.105 (0.105, 0.105)
TP53+ TC1 count 105 105 105 105 105 105 105 105 105 105 105 105 105 105 105 105
TP53+ TC1 time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
TP53+ TC1 n 7 (4, 12) 7 (3, 12) 2 (0, 5) 6 (2, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 6 (3, 12) 5 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.37 (0.14, 0.48) 0.36 (0.14, 0.47) 0.39 (0.26, 0.48) 0.31 (0.1, 0.47) 0.44 (0.44, 0.44) 0.44 (0.37, 0.48) 0.44 (0.44, 0.44) 0.43 (0.33, 0.48) 0.45 (0.4, 0.48) NA (NA, NA) 0.31 (0.16, 0.47) 0.36 (0.19, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.143 (0.107, 0.252) 0.18 (0.126, 0.318) 0.193 (0.089, 0.576) 0.177 (0.105, 0.337) 0.115 (0.023, 0.262) 0.189 (0.051, 0.707) 0.135 (0.094, 6.182) 0.172 (0.083, 0.78) 0.335 (0.026, 1.93) 0.122 (0.024, 1.302) 0.155 (0.103, 0.272) 0.162 (0.114, 0.305) 0.07 (0, 0.32) 0.11 (0.11, 0.11) 0.111 (0.022, 0.187) NA (NA, NA)
TP53+ TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TP53+ TC2 time 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18)
TP53+ TC2 n 9 (9, 9) 5 (5, 5) 2 (2, 2) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 4 (4, 4) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.45 (0.45, 0.45) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) 0.49 (0.49, 0.49) 0.36 (0.36, 0.36) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.182 (0.182, 0.182) 0.283 (0.283, 0.283) 0.295 (0.295, 0.295) 0.124 (0.124, 0.124) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.387 (0.387, 0.387) NA (NA, NA) 0.059 (0.059, 0.059) 0.199 (0.199, 0.199) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 79 79 79 79 79 79 79 79 79 79 79 79 79 79 79 79
TP53+ TC3 time 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31) 20 (15, 31)
TP53+ TC3 n 8 (4, 13) 7 (4, 11) 2 (1, 5) 5 (3, 9) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 6 (3, 11) 4 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.36 (0.16, 0.48) 0.32 (0.15, 0.47) 0.39 (0.26, 0.47) 0.31 (0.1, 0.46) 0.44 (0.44, 0.44) 0.47 (0.41, 0.49) NA (NA, NA) 0.45 (0.37, 0.5) 0.44 (0.38, 0.48) NA (NA, NA) 0.27 (0.08, 0.45) 0.35 (0.18, 0.48) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.148 (0.103, 0.244) 0.175 (0.124, 0.38) 0.256 (0.12, 0.814) 0.181 (0.103, 0.307) 0 (0, 0.524) 0.087 (0, 0.278) 0 (0, 0) 0.102 (0, 0.453) 0.485 (0.06, 2.401) 0.926 (0.185, 1.667) 0.194 (0.113, 0.353) 0.167 (0.117, 0.454) 0 (0, 0.035) 0 (0, 0.163) NA (NA, NA) 0.035 (0, 0.125)
TP53+ TC4 count 165 165 165 165 165 165 165 165 165 165 165 165 165 165 165 165
TP53+ TC4 time 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30) 20 (13, 30)
TP53+ TC4 n 7 (4, 11) 6 (3, 9) 2 (0, 4) 4 (2, 7) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 5 (2, 10) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.38 (0.19, 0.48) 0.28 (0.09, 0.45) 0.39 (0.21, 0.47) 0.26 (0.08, 0.43) NA (NA, NA) 0.47 (0.4, 0.49) 0.42 (0.42, 0.42) 0.46 (0.38, 0.49) 0.46 (0.39, 0.48) NA (NA, NA) 0.26 (0.07, 0.43) 0.27 (0.11, 0.45) 0.47 (0.46, 0.49) NA (NA, NA) NA (NA, NA) 0.45 (0.45, 0.45)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.148 (0.104, 0.254) 0.236 (0.152, 0.392) 0.314 (0.135, 1.487) 0.236 (0.142, 0.518) 0.605 (0.158, 1.052) 0.081 (0, 0.422) 0 (0, 0.282) 0.088 (0, 0.546) 0.278 (0.117, 1.298) 0.213 (0.065, 0.503) 0.237 (0.134, 0.505) 0.244 (0.119, 0.49) 0 (0, 0.259) 0 (0, 0) 0 (0, 0) 0 (0, 0.207)
TEfus+ TC1 count 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23
TEfus+ TC1 time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
TEfus+ TC1 n 1 (0, 3) 4 (1, 8) 2 (1, 5) 7 (2, 15) 2 (0, 8) 2 (0, 4) 0 (0, 1) 1 (0, 3) 1 (0, 3) 1 (0, 4) 8 (3, 10) 6 (3, 11) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.44 (0.4, 0.48) 0.4 (0.18, 0.49) 0.38 (0.19, 0.47) 0.27 (0.12, 0.47) 0.36 (0.2, 0.46) 0.41 (0.37, 0.47) NA (NA, NA) 0.41 (0.33, 0.47) 0.42 (0.29, 0.49) 0.41 (0.32, 0.49) 0.28 (0.15, 0.39) 0.3 (0.21, 0.43) 0.44 (0.41, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.131 (0.068, 0.594) 0.085 (0.077, 0.215) 0.235 (0.172, 0.413) 0.146 (0.099, 0.309) 0.133 (0.077, 0.362) 0.105 (0.072, 0.315) 0.467 (0.201, 8.241) 0.16 (0.077, 1.286) 0.221 (0.112, 0.564) 0.184 (0.118, 0.538) 0.167 (0.115, 0.369) 0.157 (0.109, 0.274) 0.112 (0, 0.243) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 36 36 36 36 36 36 36 36 36 36 36 36 36 36 36 36
TEfus+ TC3 time 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30) 22 (16, 30)
TEfus+ TC3 n 0 (0, 2) 4 (2, 8) 2 (1, 4) 6 (3, 10) 2 (0, 6) 1 (0, 2) 0 (0, 0) 0 (0, 2) 2 (1, 5) 2 (0, 3) 7 (4, 9) 5 (2, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.39 (0.21, 0.46) 0.28 (0.16, 0.42) 0.39 (0.29, 0.47) 0.29 (0.14, 0.43) 0.44 (0.33, 0.49) 0.44 (0.38, 0.47) NA (NA, NA) 0.47 (0.39, 0.49) 0.38 (0.16, 0.47) 0.42 (0.28, 0.48) 0.24 (0.08, 0.42) 0.27 (0.08, 0.44) 0.46 (0.44, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.309 (0.11, 1.156) 0.181 (0.103, 0.604) 0.227 (0.114, 0.629) 0.179 (0.106, 0.279) 0.101 (0.044, 0.338) 0.107 (0.005, 0.443) NA (NA, NA) 0.099 (0.01, 0.614) 0.214 (0.122, 0.843) 0.239 (0.054, 0.428) 0.216 (0.133, 0.345) 0.199 (0.123, 0.572) 0.196 (0.129, 0.547) 0 (0, 0) NA (NA, NA) 0.054 (0.011, 0.097)
TEfus+ TC4 count 67 67 67 67 67 67 67 67 67 67 67 67 67 67 67 67
TEfus+ TC4 time 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29)
TEfus+ TC4 n 1 (0, 4) 4 (2, 8) 2 (0, 4) 5 (2, 7) 3 (0, 6) 1 (0, 3) 0 (0, 0) 0 (0, 1) 2 (1, 4) 1 (0, 3) 6 (3, 11) 4 (2, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.4 (0.31, 0.46) 0.25 (0.1, 0.43) 0.42 (0.24, 0.47) 0.17 (0.05, 0.42) 0.45 (0.32, 0.49) 0.45 (0.39, 0.5) 0.48 (0.48, 0.48) 0.45 (0.4, 0.49) 0.37 (0.18, 0.48) 0.39 (0.24, 0.43) 0.2 (0.06, 0.41) 0.24 (0.09, 0.45) 0.46 (0.41, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.282 (0.144, 1.109) 0.229 (0.115, 0.573) 0.242 (0.131, 0.848) 0.289 (0.143, 0.528) 0.093 (0.052, 0.241) 0.086 (0.03, 0.219) 0.176 (0.035, 0.317) 0.109 (0, 0.207) 0.244 (0.15, 0.588) 0.343 (0.164, 1.081) 0.247 (0.151, 0.47) 0.214 (0.123, 0.408) 0 (0, 0.19) 0.05 (0.01, 0.09) 0 (0, 0) 0.102 (0.02, 0.184)
PI3K+ TC1 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
PI3K+ TC1 time 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34) 18 (12, 34)
PI3K+ TC1 n 4 (2, 8) 3 (2, 5) 6 (3, 12) 5 (4, 9) 0 (0, 0) 1 (0, 4) 0 (0, 1) 1 (0, 4) 0 (0, 2) 1 (0, 2) 0 (0, 0) 6 (4, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.42 (0.28, 0.5) 0.42 (0.35, 0.48) 0.39 (0.22, 0.43) 0.35 (0.24, 0.43) NA (NA, NA) 0.43 (0.39, 0.47) 0.44 (0.39, 0.44) 0.36 (0.21, 0.46) 0.4 (0.39, 0.42) 0.49 (0.41, 0.49) 0.45 (0.45, 0.45) 0.38 (0.29, 0.45) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.117 (0.1, 0.162) 0.112 (0.072, 0.221) 0.197 (0.14, 0.366) 0.142 (0.119, 0.248) NA (NA, NA) 0.086 (0.022, 0.29) 0.325 (0.059, 0.813) 0.189 (0.084, 0.605) 1.028 (0.276, 1.163) 0.074 (0, 0.268) 0.193 (0.193, 0.193) 0.157 (0.126, 0.18) 0.394 (0.394, 0.394) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
PI3K+ TC2 time 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25) 15 (13, 25)
PI3K+ TC2 n 8 (4, 8) 1 (0, 6) 5 (4, 5) 6 (6, 7) 0 (0, 0) 2 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 1) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.36 (0.35, 0.38) 0.48 (0.47, 0.48) 0.28 (0.27, 0.32) 0.47 (0.36, 0.48) NA (NA, NA) 0.41 (0.4, 0.42) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA) 0.48 (0.33, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.142 (0.128, 0.15) 0.193 (0.073, 0.313) 0.204 (0.199, 0.541) 0.108 (0.106, 0.123) NA (NA, NA) 0.516 (0.226, 0.806) 0.193 (0.193, 0.193) 0.067 (0.013, 0.12) 0 (0, 0) 0.111 (0.111, 0.111) 0.203 (0.203, 0.203) 0.097 (0.084, 0.11) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 count 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87
PI3K+ TC3 time 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30) 20 (14, 30)
PI3K+ TC3 n 8 (5, 13) 4 (1, 7) 7 (3, 11) 5 (3, 9) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.26 (0.07, 0.44) 0.34 (0.11, 0.46) 0.31 (0.12, 0.47) 0.32 (0.13, 0.46) NA (NA, NA) 0.45 (0.38, 0.49) 0.46 (0.4, 0.49) 0.45 (0.41, 0.49) 0.42 (0.35, 0.48) 0.42 (0.32, 0.49) NA (NA, NA) 0.32 (0.17, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.175 (0.118, 0.276) 0.183 (0.098, 0.481) 0.192 (0.14, 0.388) 0.165 (0.098, 0.301) 1.333 (0.419, 2.246) 0.087 (0, 0.33) 0.098 (0, 0.531) 0.106 (0, 0.475) 0.287 (0.129, 1.19) 0.25 (0.055, 1.205) NA (NA, NA) 0.178 (0.114, 0.544) NA (NA, NA) NA (NA, NA) 0 (0, 0.26) 0 (0, 0)
PI3K+ TC4 count 154 154 154 154 154 154 154 154 154 154 154 154 154 154 154 154
PI3K+ TC4 time 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27)
PI3K+ TC4 n 7 (4, 11) 3 (1, 7) 6 (3, 10) 5 (2, 7) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.18 (0.03, 0.35) 0.3 (0.12, 0.43) 0.27 (0.12, 0.43) 0.25 (0.09, 0.43) NA (NA, NA) 0.46 (0.37, 0.49) 0.46 (0.41, 0.5) 0.45 (0.4, 0.5) 0.44 (0.36, 0.49) 0.41 (0.31, 0.47) NA (NA, NA) 0.29 (0.08, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.47 (0.47, 0.47)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.238 (0.148, 0.416) 0.228 (0.11, 0.598) 0.23 (0.153, 0.386) 0.239 (0.138, 0.481) 0 (0, 0) 0.077 (0, 0.247) 0.102 (0, 0.392) 0.105 (0, 0.54) 0.362 (0.103, 1.483) 0.362 (0.11, 1.083) 4.955 (4.955, 4.955) 0.245 (0.106, 0.461) 0 (0, 0.114) 0.05 (0.01, 0.09) 0 (0, 0.103) 0 (0, 0.207)